Method for realizing transformation of organic compound from amorphous state to crystalline state in polymer nanoparticles

A nanoparticle, amorphous technology, applied in the application field of the amphiphilic polymer Pluronic F127, can solve the problem of affecting the application, affecting the photophysical properties of molecular aggregates, the superiority reduction of long wavelength and strong penetration, etc. problems, to achieve the effect of improved light absorption, deep tissue penetration, and high imaging sensitivity

Pending Publication Date: 2022-04-05
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

However, this stacking method affects the photophysical properties of the molecular aggregation state, which reduces the expected advantages of long wavelength and strong penetrating power, and affects its application in bioimaging and other fields.
[0006] In view of the fact that the research on the transformation of the stacking mode of fluorescent molecules in amphiphilic polymer nanoparticles is still blank, an efficient, convenient and low-cost preparation method is needed to realize the transformation of the stacking mode of fluorescent molecules in polymer nanoparticles. This helps to further optimize the comprehensive performance of nanoparticles

Method used

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  • Method for realizing transformation of organic compound from amorphous state to crystalline state in polymer nanoparticles
  • Method for realizing transformation of organic compound from amorphous state to crystalline state in polymer nanoparticles
  • Method for realizing transformation of organic compound from amorphous state to crystalline state in polymer nanoparticles

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Embodiment 1

[0024] Step 1. Dissolve 10 mg of OPTPA in 10 ml of tetrahydrofuran to prepare a mother solution of 1 mg per ml for use. Weigh 100 mg of amphiphilic polymer Pluronic F127, take 5 ml of the above mother solution and add 100 mg of amphiphilic polymer Pluronic F127 was ultrasonicated for 5 minutes to obtain a clear solution for later use; take a glass vial with a screw cap and add 2 ml of pure water; quickly inject the clear solution prepared in the first step into pure water under ultrasonic conditions;

[0025] Step 2. The mixture obtained in Step 1 was continuously ultrasonicated for 20 minutes, and the rotor was put into the glass vial. Subsequently, the above-mentioned mixed solution was transferred to a room temperature stirrer and continued to stir until all the organic solvents evaporated to obtain a purple nanoparticle solution, which was confirmed by XRD testing that the organic fluorescent molecule OPTPA in the nanoparticles was in an amorphous state;

[0026] Step 3. C...

Embodiment 2

[0029] Step 1. Dissolve 10 mg of OPTPA in 10 ml of tetrahydrofuran to prepare a mother solution of 1 mg per ml for use. Weigh 80 mg of amphiphilic polymer Pluronic F127, take 4 ml of the above mother solution and add 80 mg of amphiphilic polymer Pluronic F127 was ultrasonicated for 5 minutes to obtain a clear solution for later use; take a glass vial with a screw cap and add 2 ml of pure water; quickly inject the clear solution prepared in the first step into pure water under ultrasonic conditions;

[0030] Step 2. The mixture obtained in Step 1 was continuously ultrasonicated for 20 minutes, and the rotor was put into the glass vial. Subsequently, the above-mentioned mixed solution was transferred to a room temperature stirrer and continued to stir until all the organic solvents evaporated to obtain a purple nanoparticle solution, which was confirmed by XRD testing that the organic fluorescent molecule OPTPA in the nanoparticles was in an amorphous state;

[0031] Step 3. Com...

Embodiment 3

[0034] Step 1. Dissolve 10 mg of OPTPA in 10 ml of tetrahydrofuran to prepare a mother solution of 1 mg per ml for use. Weigh 60 mg of amphiphilic polymer Pluronic F127, take 3 ml of the above mother solution and add 60 mg of amphiphilic polymer Pluronic F127 was ultrasonicated for 5 minutes to obtain a clear solution for later use; take a glass vial with a screw cap and add 2 ml of pure water; quickly inject the clear solution prepared in the first step into pure water under ultrasonic conditions;

[0035] Step 2. The mixture obtained in Step 1 was continuously ultrasonicated for 20 minutes, and the rotor was put into the glass vial. Subsequently, the above-mentioned mixed solution was transferred to a room temperature stirrer and continued to stir until all the organic solvents evaporated to obtain a purple nanoparticle solution, which was confirmed by XRD testing that the organic fluorescent molecule OPTPA in the nanoparticles was in an amorphous state;

[0036] Step 3. Com...

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Abstract

The invention discloses a method for realizing transformation of an organic fluorescent material from an amorphous state to a crystalline state in polymer nanoparticles, which comprises the following steps: preparing the organic fluorescent material with the amorphous state in the nanoparticles according to a conventional nanoparticle precipitation method, volatilizing all solvents of purple nanoparticle suspension in the step 3 of a synthesis method, and then preparing the organic fluorescent material with the amorphous state in the polymer nanoparticles. And adding purified water again to obtain the organic fluorescent material with the ordered crystalline state in the nanoparticles. The XRD test proves that the organic fluorophore OPTPA in the nanoparticles is in a crystal state. According to the invention, an organic material OPTPA with an aggregation-induced emission property is used as a core, Pluronic F127 is used as a coating material, and the conversion of a material accumulation mode in a shell is realized by adjusting the content of the organic material and the Pluronic F127 and the preparation process of the nanoparticles. The absorption and emission wavelengths of the obtained blue nanoparticles are both in red shift, and the advantages of high imaging sensitivity, deep tissue penetrating power and the like are obviously improved due to long-wavelength emission, so that the comprehensive performance of the nanoparticles is further optimized.

Description

Technical field: [0001] The invention belongs to the field of aggregation-induced luminescent nanometer materials, in particular to an application of coating the aggregation-induced luminescent material in the amphiphilic polymer Pluronic F127. Specifically, water is used as the dispersion solvent, organic materials with aggregation-induced luminescent properties are used as the core, and Pluronic F127 is used as the coating material. The coating material is realized by adjusting the content of organic materials and Pluronic F127 and the preparation process of nanoparticles. Changes in the way organic fluorescent materials are stacked. [0002] Background of the invention: [0003] In recent years, near-infrared-emitting organic fluorescent molecules have been widely used in biological imaging and imaging-guided optical therapy due to their high imaging sensitivity, deep tissue penetration ability, and small biological autofluorescence interference. Research areas. [0004]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C253/32C07C255/42C09K11/06B82Y40/00
Inventor 吕宏光赵晓伟王鲜
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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