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Low-irritation gamma-aminobutyric acid product, preparation method thereof and application of low-irritation gamma-aminobutyric acid product to irritation reduction
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An aminobutyric acid and irritating technology, applied in the field of biomedicine, can solve the problems of tingling, limited use, small molecular weight, etc., and achieve the effect of reducing discomfort
Pending Publication Date: 2022-04-12
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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GABA has a small molecular weight and can quickly penetrate the skin and relax tense muscles, thereby significantly reducing fine lines and wrinkles, but it will bring immediate discomfort when used, especially tingling, which limits its use in cosmetics
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[0033] In particular, the problem of discomfort in the prior art, in particular a tingling sensation, the present invention provides a method of preparation of low irritating gamma-aminobutyric acid products, the preparation method including The following steps:
[0034] Step 1: Incorporate yeast into a solution containing γ-aminobutyric acid to ferment,
[0035] Step 2: After the end of the fermentation, the bacteria in the fermentation broth were broken, filtered, and the filtrate containing γ-aminobutyric acid was obtained.
[0036] Further, the preparation method can include step three:
[0037] Step 3: Add the filtrate to the excipient to spray dry to give a low irritating γ-aminobutyric acid composition.
[0038] That is, the γ-aminobutyric acid product according to the present invention may be a product comprising a variety of forms of gamma-aminobutyric acid, and may be, for example, a filtrate containing γ-aminobutyric acid, or a dry gamma-based ammonia Acid composition.
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Embodiment 1
[0061] Example 1 Saccharomyces Cerevisiae WJ-37 Screening and Identification Process
[0062] With the raw material of the Bohai sea mud, the Bohai sea mud is dispersed with 100-quality sterile water, and each solution is evenly applied to a yeastsolid medium plate containing 0.1 mg / L ampicillinsodium with a coater. When the Centers of Casculation is deposited from 1 to 2 days, the colonies are selected from the mesenger form, inoculated on the yeastsolid medium tube, in the incubator of the 25 ° C incubator, and then cultured from 1 to 2d, and the bacterium is long. Refrigerator on 4 ° C. Among them, yeast solid medium: protein 胨 20g / L, yeast powder 10g / L, glucose 20g / L, agar 20g / L, the rest is water.
[0067] Saccharomyces Cerevisiae WJ-37 on the yeast solid medium plate, colony surface smooth, moist, neat edge, uniform texture, uniform color, such as figure 1 As shown; the bacteria is a single cell, a formation, simple morphology, sprouting, such as figure 2 Indicated.
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Abstract
The invention provides Saccharomyces cerevisiae, and the preservation number of the Saccharomyces cerevisiae is CCTCC (China Center for Type Culture Collection) NO: M 20211621. The invention also provides a preparation method of the low-irritation gamma-aminobutyric acid product, and the preparation method comprises the following steps: inoculating saccharomycetes into a solution containing gamma-aminobutyric acid for fermentation, crushing and filtering thalli in fermentation liquor after fermentation is finished to obtain filtrate containing gamma-aminobutyric acid, and filtering the filtrate containing gamma-aminobutyric acid to obtain the low-irritation gamma-aminobutyric acid product. Furthermore, auxiliary materials can be added into the filtrate for spray drying to obtain the low-irritation gamma-aminobutyric acid composition. The invention finds that the pricking feeling of the gamma-aminobutyric acid is possibly partially caused by impurity components in the gamma-aminobutyric acid product, but by the production process provided by the invention, not only can part of the impurities causing irritation be consumed, but also anti-allergy components can be generated, so that the discomfort caused by the gamma-aminobutyric acid is reduced.
Description
Technical field [0001] The present invention belongs to the field of biomedicine, and more particularly to a low irritating γ-aminobutyric acid composition and a preparation method thereof. Background technique [0002] γ-aminobutyric acid, referred to as GABA, is a naturally occurring non-proteinamino acid, is widely distributed in the animal, but the content is low. In the animal, GABA is only in neuromatoid, and is an important inhibitory neurological activity in mammalian central nervous system, participating in various metabolism and physiological activities in the human body. When the GABA in the human body is lacking, an anxiety, uneasiness, fatigue, and worry are produced. [0003] GABA has more applications in food health products, and can also be used as drugs for treating diseases, and is also an internationally recognized cosmetic raw material, which is included in the domestic cosmetic raw material catalog. The GABA is small, can quickly penetrate the skin, relax ti...
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