Gold nanorod array glucose sensor with high-order surface plasmon mode and manufacturing and using methods

Abstract

The invention discloses a gold nanorod array glucose sensor with a high-order surface plasmon mode and a manufacturing and using method thereof. The gold nanorod array glucose biosensor comprises a gold nanorod array, catechol ethylamine molecules and concanavalin molecules. A catechol ethylamine molecular layer is formed on the surface of the gold nanorod array, and concanavalin molecules are fixed on the surface by utilizing the adhesion of the molecular layer, so that the specific modification of the gold nanorod array is completed. When glucose molecules and concanavalin molecules are specifically combined, the reflection spectrum of the gold nanorod array glucose sensor is changed, and the resonance wavelength of a high-order mode in the reflection spectrum is obviously shifted along with the increase of the concentration of a glucose solution, so that the high-sensitivity specific detection of glucose is realized. The glucose biosensor has the advantages of ultrahigh sensitivity, simplicity in operation, no label and the like, and can play an indispensable role in future glucose detection.

Description

technical field [0001] The invention relates to the technical field of biosensors with noble metal array structures, in particular to a gold nanorod array glucose sensor with a high-order surface plasmon mode and its production and use methods. Background technique [0002] Surface plasmons (SPs) are collective oscillations of electrons localized at the interface between metals and dielectrics. When certain conditions are met, SPs and photons will couple. At this time, the incident light is strongly absorbed, which is shown in the reflection spectrum as A trough will form at a certain wavelength. The position of the trough is very sensitive to the change of the refractive index of the dielectric in the surrounding environment. Compared with the traditional biosensor, the plasmonic biosensor designed based on this principle has the advantages of not requiring modification or further labeling of the analyte, and is not affected by the environment, etc. Factors or the influenc...

AI Technical Summary

Problems solved by technology

However, for diabetes, there is still no way to completely eradicate it. The only way to prevent and reduce the incidence of diabetes is to detect the concentration of glucose in the individual's blood or other body fluids.

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