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Quality control method of Guilong ointment

A quality control method and technology of ointment, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as the inability to guarantee the quality of raw materials, and achieve the effects of good repeatability and stability, high sensitivity, and strong specificity

Active Publication Date: 2022-04-22
GUANGXI BANGQI PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that there are no identification and content determination items in the current quality standard of Guilong ointment, and the existing raw material processing methods cannot guarantee the quality of raw materials, the present invention provides a quality control method for Guilong ointment, which is an accurate, fast , The stable quality control method of Guilong Ointment can better control the quality of the traditional Chinese medicine preparation, ensure the safety of medication, and guide the quality control of the product production process to be more reasonable

Method used

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  • Quality control method of Guilong ointment
  • Quality control method of Guilong ointment
  • Quality control method of Guilong ointment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] A kind of quality control method of Osmanthus ointment, comprises the steps:

[0100] 1) Using cinnamon leaf reference material, coumarin reference substance, soil licorice reference material, Shouwu vine reference material, and emodin reference substance, cinnamon leaf, soil licorice, and Shouwu vine were identified by thin-layer chromatography;

[0101] The cinnamon leaf is identified by thin-layer chromatography, which specifically includes the following steps: take 10g of this product, add 5ml of water, shake up, add 40ml of ethyl acetate, ultrasonically treat for 30min, divide the ethyl acetate solution and evaporate to dryness, and the residue Add 1ml of ethyl acetate to dissolve, and use it as the test solution; take 1g of cinnamon leaves as a reference medicinal material, add 50ml of water, shake well, decoct for 30 minutes, filter, concentrate the filtrate to about 10ml, add 40ml of ethyl acetate, and sonicate for 30min , the same method as the reference drug s...

experiment example 1

[0185] Experimental Example 1: Screening process of Guilong Ointment Identification Research Test

[0186] 1. Niu Dali

[0187] Sample preparation: Take ① 20g of Guilong ointment, ② 20g of Guilong ointment plus 10g of diatomite, ③ 20g of Guilong ointment lacking Niu Dali negative, ④ 2g of Niu Dali medicinal material, add 1ml of concentrated ammonia test solution and 50ml of chloroform respectively, Sonicate for 1 hour, filter, evaporate the filtrate to dryness, add 1ml of chloroform to dissolve the residue, and obtain the obtained product.

[0188] Silica gel G plate, cyclohexane-ethyl acetate (20:3)

[0189] Inspection: After standing for 2 hours, inspect under 365nm; spray 10% sulfuric acid ethanol solution to dry, then inspect under 365nm, and finally heat at 105°C until the spots are clearly colored, and inspect under sunlight and 365nm fluorescence respectively. Conclusion: On the spot position corresponding to the test sample and the medicinal material, there is interf...

experiment example 2

[0268] Experimental Example 2: Liquid Phase Screening Test of Guilong Ointment

[0269] 1. Determination method of soil licorice content

[0270] Chromatographic conditions: No. 15 C 18 For the column, the mobile phase is acetonitrile-water-glacial acetic acid (70:30:0.08), the detection wavelength is 207nm, the flow rate is 1ml / min, the column temperature is 40°C, and the injection volume is 20ul.

[0271] Betulinic acid reference substance (batch number: 111802-202004, for identification) solution: accurately weigh 8.80mg of betulinic acid in a 25ml measuring bottle, dissolve in methanol to constant volume, shake well for later use; put 5ml of precision reserve solution in a 25ml measuring bottle In the solution, dilute to volume with methanol and shake well to obtain a 70.4ug / ml control solution.

[0272] Precisely weigh 1 g of licorice and 25 g of guilong ointment, put them into conical flasks, add 80 ml of 95% ethanol, heat to reflux for 1 hour, let cool, and filter to ...

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Abstract

The invention discloses a quality control method of a Guilong ointment, which mainly comprises the items of identification and content determination, and takes a cinnamon leaf reference medicinal material, a coumarin reference substance, a solanum melongena reference medicinal material, a vine of multiflower knotweed, an emodin reference substance and a cinnamic acid reference substance as detection indexes of the identification method and the content determination method of the traditional Chinese medicine preparation. The quality control method provided by the invention can better control the quality of the Guilong ointment preparation product. The method has the characteristics of strong specificity, high accuracy, high sensitivity, rapidness, stability and the like, can comprehensively react and control the quality of the Guilong ointment, and is an excellent production quality control method.

Description

【Technical field】 [0001] The invention relates to the technical field of drug quality detection, in particular to a quality control method for Guilong Ointment. 【Background technique】 [0002] Osmanthus ointment, from the source of human disease, regulates from the perspective of liver, heart, spleen, lung, and kidney. Guilong Ointment is recorded in the eighth volume of Ministry-issued Standard Traditional Chinese Medicine Prescriptions WS3-B-1599-93 and the State Food and Drug Administration standard YBZ22432005; it has the effects of expelling wind and dampness, relaxing tendons and activating collaterals, warming kidney and nourishing blood. For rheumatic bone pain, chronic low back pain, anemia caused by deficiency of kidney yang and deficiency of qi and blood, insomnia, dreaminess, shortness of breath, palpitation, hyperhidrosis, anorexia, abdominal distension, frequent urination, etc. [0003] Guilong ointment, its prescription is: cinnamon leaf 300g, Smilax 30g, Hon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/90
CPCG01N30/02G01N30/90G01N2030/027Y02A50/30
Inventor 韩宇强陈国莫合军
Owner GUANGXI BANGQI PHARMA GRP CO LTD
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