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Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury or acute respiratory distress syndrome

A technology of flavonoids and acute respiratory distress, which is applied in the field of medicine to achieve the effect of reducing the wet weight and dry weight of the lungs, reducing the content of inflammatory factors, and reducing the generation of pulmonary effusion

Pending Publication Date: 2022-05-06
CATCH BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Regarding this 6,7 methoxy substituted flavonoids, there is no report on its use in the treatment of acute lung injury or acute respiratory distress syndrome

Method used

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  • Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury or acute respiratory distress syndrome
  • Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury or acute respiratory distress syndrome
  • Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury or acute respiratory distress syndrome

Examples

Experimental program
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Effect test

Embodiment 1

[0049] The preparation of embodiment 1 compound 1-4

[0050] Take 1 kg of fresh Rutaceae citrus flowers, crush them, add 5 times the weight of 70% aqueous methanol solution for ultrasonic extraction at room temperature for 3 times, each time for 1 hour, combine the extracts, concentrate under reduced pressure to obtain extracts, and extract the extracts sequentially with petroleum Ether, chloroform, ethyl acetate extraction (each kind of solvent extraction 3 times, each extraction solvent is 3 times of extractum volume), each kind of extracting solution is combined respectively, and concentrated under reduced pressure, obtain petroleum ether extract, chloroform extract and Ethyl acetate extract. The chloroform extract was separated using silica gel column chromatography, petroleum ether-acetone (100:0, 50:1, 30:1, 15:1, 5:1, 2:1, 1:1, 1:20, 0 : 100) gradient elution, according to thin-layer chromatography (TLC) detection results combined eluent at the same spot position, to o...

Embodiment 2

[0057] The preparation of embodiment 2 compound 5-7

[0058] Take 8kg of dried stems and leaves of Radix radix, crush them, soak them in 50L of 80% ethanol aqueous solution at room temperature and extract, extract 3 times, each time for 1 week, combine the extracts 3 times, concentrate under reduced pressure to obtain extracts, and use petroleum extracts in turn Ether and ethyl acetate are extracted (each solvent is extracted 3 times, and each extraction solvent is 3 times the volume of the extract), and each extract is combined and concentrated under reduced pressure to obtain petroleum ether extract and ethyl acetate extract . The ethyl acetate extract was separated by silica gel column chromatography, and Fr1-Fr3 was obtained by gradient elution of petroleum ether-acetone (20:1, 10:1, 5:1), and Fr2 was separated by semi-preparative reversed-phase liquid chromatography. Gradient elution with aqueous methanol (20% aqueous methanol-35% aqueous methanol-45% aqueous methanol) y...

Embodiment 3

[0064] The preparation of embodiment 3 compound 8-14

[0065] Take 10kg of the peel of fresh Rutaceae oranges, crush them, add 4 times the weight of 90% ethanol aqueous solution, soak and extract at room temperature, and extract 3 times, each time for 1 week. Combine the extracts, concentrate under reduced pressure to obtain the extract, extract the extract successively with ethyl acetate and n-butanol (each solvent is extracted 3 times, and each extraction solvent is 3 times the volume of the extract), and each extract The liquids were combined and concentrated under reduced pressure to obtain ethyl acetate extract and n-butanol extract. The ethyl acetate extract was separated by silica gel column chromatography, using ethyl acetate-n-butanol (5:1, 3:1, 1:1, 1:2) gradient elution, and the same spot positions were combined according to the TLC detection results The eluent of FrE-1 to FrE-7 was obtained, and FrE-3 was separated by semi-preparative reversed-phase liquid chromat...

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Abstract

The invention provides application of a flavonoid compound in preparation of a medicine for preventing or treating acute lung injury or acute respiratory distress syndrome. The application of the 6, 7-methoxy-substituted flavonoid compound shown in the formula (I) in preparation of the medicine for preventing or treating the acute lung injury or the acute respiratory distress syndrome is provided for the first time, and the flavonoid compound provided by the invention can obviously relieve inflammatory response caused by the acute lung injury and can be used for preparing the medicine for preventing or treating the acute lung injury or the acute respiratory distress syndrome. The traditional Chinese medicine composition can be used for preventing and treating acute lung injury, reducing the content of inflammatory factors in alveolus pulmonis and serum, reducing the generation of pulmonary effusion, inhibiting lung edema caused by acute lung injury while resisting inflammation, has the advantages of low dosage and remarkable curative effect, and can be used as a potential medicine for preventing or treating acute lung injury. Therefore, the application field of the 6, 7-methoxy-substituted flavonoid compound is expanded.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the use of a flavonoid compound in the preparation of medicines for preventing or treating acute lung injury or acute respiratory distress syndrome. Background technique [0002] Acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is a common clinical critical illness with a high mortality rate, which seriously threatens the lives of critically ill patients. According to statistics, more than 10% of ALI patients need to be admitted to intensive care unit for treatment, and the fatality rate is as high as 32%-55%. bronchial asthma or myocardial infarction etc. on a par. The basic pathophysiological change of ALS / ARDS is non-cardiogenic pulmonary edema caused by increased permeability of alveolar epithelial cells and pulmonary capillary endothelium, severe ventilation / blood flow imbalance due to alveolar water and alveolar collapse, especially in the lungs. The shunt increa...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/357A61P11/00A61P31/04A61P31/14
CPCA61K31/352A61K31/357A61P11/00A61P31/04A61P31/14
Inventor 温尧林徐海霞
Owner CATCH BIO SCI & TECH
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