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KdPT polypeptide for treating acute lung injury and application thereof

A technology for acute lung injury and medicine, applied in the field of KdPT polypeptide for the treatment of acute lung injury, to achieve the effects of simple medication, improvement of lung tissue pathology, and reduction of lung permeability index and inflammatory factor levels

Pending Publication Date: 2022-05-06
LINK HEALTH GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no technical reports related to the use of KdPT polypeptides in the treatment of acute lung injury

Method used

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  • KdPT polypeptide for treating acute lung injury and application thereof
  • KdPT polypeptide for treating acute lung injury and application thereof
  • KdPT polypeptide for treating acute lung injury and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1. The therapeutic effect of KdPT polypeptide on acute lung injury in rats.

[0024] Modeling: After anesthetizing 8-week-old SPF male SD rats, disinfect the neck of the rat with iodine wine, make a longitudinal incision of about 1 cm at the midline position of the middle and lower third of the neck, expose the lower edge of the thyroid gland and turn it up, carefully Separate and expose the anterior muscle group of the trachea, longitudinally and sharply separate the muscle group to expose the trachea, place the animal obliquely with the head high and the soles of the feet, insert a 1mL syringe (26G) into the trachea at about two tracheal rings under the cricoid cartilage ring, and inject 2mg / kg LPS Solution, the administration volume is 0.8mL / kg, observe that there are no air bubbles in the nose, and immediately rotate the rat upright for 20 seconds after pushing to ensure that the liquid is evenly distributed in the lung tissue and that the drug fully enters t...

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PUM

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Abstract

The invention relates to the technical field of biology, and particularly discloses a KdPT polypeptide for treating acute lung injury and application of the KdPT polypeptide. It is found for the first time that the polypeptide KdPT has the effects of obviously improving the lung function of a rat with the acute lung injury, reducing the death rate of an animal with the acute lung injury and obviously reducing the lung permeability coefficient, the level of inflammatory factors and the lung tissue pathological score, and therefore the KdPT polypeptide has the obvious treatment effect on the acute lung injury, and has a good application prospect. The effect of the medicine is superior to or not inferior to that of the existing treatment medicine, and the medicine is expected to be developed into a novel medicine for treating acute lung injury. The KdPT polypeptide provided by the invention can be prepared into an oral preparation or an injection, and is simpler and more convenient to use.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a KdPT polypeptide for treating acute lung injury and its application. Background technique [0002] Acute lung injury (ALI) is a clinical syndrome that occurs due to characteristic pathological changes in lung tissue structure caused by various reasons. Its pathological features are alveolar capillary endothelial cells and alveolar epithelial cell damage, manifested as extensive pulmonary edema and tiny atelectasis. The pathophysiological changes are mainly increased intrapulmonary shunt and decreased lung compliance. Clinically, hypoxemia, rapid respiratory rate, and diffuse infiltration of both lungs appeared on chest X-ray. ALI has a continuous process from mild to severe, and there is still a lack of effective drugs and methods for the treatment of acute lung injury. [0003] KdPT polypeptide is a reported anti-inflammatory tripeptide, the sequence is: KPT, that is, an oligop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/06A61P11/00A61P29/00
CPCA61K38/06A61K9/0053A61K9/0019A61P11/00A61P29/00
Inventor 张时群申玲许元生林华燕何少峰
Owner LINK HEALTH GRP