Metabolite for predicting and treating obesity and/or diabetes and preparation thereof

A metabolite, diabetes technology, applied in the fields of biology and medicine, can solve the problems of inability to stably control blood sugar changes and weight gain for a long time, and achieve the effects of avoiding toxic side effects, reducing blood sugar, and being cheap.

Pending Publication Date: 2022-05-06
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, diabetes can be treated with oral drugs, most of which have strict requirements for taking time and cannot control blood sugar changes stably for a long time; in addition, existing hypoglycemic drugs can also cause many adverse reactions such as weight gain, and patients can benefit from hypoglycemic At the same time, the body is also affected by the side effects of drugs

Method used

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  • Metabolite for predicting and treating obesity and/or diabetes and preparation thereof
  • Metabolite for predicting and treating obesity and/or diabetes and preparation thereof
  • Metabolite for predicting and treating obesity and/or diabetes and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Body weight or body mass index (BMI), fasting blood glucose and blood taurodeoxycholic acid (TDCA), blood glycodeoxycholic acid (GDCA), blood tauroursodeoxycholic acid (TUDCA), blood glycodeoxycholic acid The content of deoxycholic acid (GUDCA) was significantly negatively correlated and significantly positively correlated with fecal deoxycholic acid (DCA) and fecal ursodeoxycholic acid (UDCA)

Embodiment 11

[0067] 403 healthy population samples (including 167 males and 236 females) aged 20 to 60 years old were analyzed for blood bile acids, the results are as follows: figure 1 The results showed that in healthy people, blood taurodeoxycholic acid (TDCA) content was significantly negatively correlated with body mass index (BMI), and it was significantly negatively correlated with age, gender, serum total cholesterol (TC), triglyceride (TG) The post-correlation is still significant. The results show that blood taurodeoxycholic acid (TDCA) can be used as a new predictor and diagnostic index of obesity.

[0068] 402 healthy population samples (including 167 males and 235 females) aged 20 to 60 years old were analyzed for blood bile acids, and the results were as follows: figure 2 showed that in healthy people, blood tauroursodeoxycholic acid (TUDCA) content was significantly negatively correlated with body mass index (BMI). The results show that blood tauroursodeoxycholic acid (TU...

Embodiment 12

[0071] The fecal bile acids of 379 healthy population samples (including 169 males and 210 females) aged 20 to 60 years old were analyzed, and the results were as follows: Figure 4 The results showed that in healthy people, the content of deoxycholic acid (DCA) in feces was significantly positively correlated with body mass index (BMI), and it was significantly positively correlated with age, gender, serum total cholesterol (TC), triglyceride (TG) The post-correlation is still significant. The results suggest that fecal deoxycholic acid (DCA) can be used as a new predictor and diagnostic indicator of obesity.

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Abstract

The invention provides a metabolite and a preparation for predicting and treating obesity and / or diabetes. The metabolite comprises one or more of taurodeoxycholic acid, tauroursodeoxycholic acid, glycodeoxycholic acid, glycoursodeoxycholic acid, deoxycholic acid and ursodeoxycholic acid. The metabolite is verified through data analysis of samples of healthy people and animal experiments. The metabolite provided by the invention is significantly related to weight / body mass index and fasting blood-glucose; in mouse models with different diseases, taurodeoxycholic acid and tauroursodeoxycholic acid have the curative effects of reducing body weight and blood sugar, and one of the action mechanisms is to inhibit the energy absorption process of the intestinal tract of the body. Therefore, the metabolite or composition disclosed by the invention can be used as a predictor and a potential therapeutic drug for obesity and / or diabetes.

Description

technical field [0001] The invention relates to the fields of medicine and biotechnology, in particular to a metabolite for predicting and treating obesity and / or diabetes and its preparation. Background technique [0002] Obesity is a major metabolic complication associated with poor eating habits and a sedentary lifestyle. It is traditionally defined as excess body fat that poses a threat to health. Body mass index (BMI) is usually used to evaluate obesity. important clinical indicators. The increasing prevalence of obesity has become a worldwide problem. According to the latest report of the World Health Organization (WHO), since 1975, the number of obese people in the world has nearly tripled, and overweight people account for 39% of the adult population. , its number reaches more than 1.9 billion, of which the number of obese people exceeds 13%, reaching 650 million people. According to the latest statistics, the prevalence of overweight in China from 2015 to 2019 was...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K31/575A61P3/04A61P3/10G01N33/66G01N33/50
CPCA61K49/0008A61K31/575A61P3/04A61P3/10G01N33/66G01N33/50
Inventor 李潇杨洁洪尚宇唐惠儒郑琰
Owner FUDAN UNIV
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