57 results about "Desoxycholic acid" patented technology

A method and pharmaceutical composition for the enhancement of transfer of a therapeutic agent to a cell wherein the therapeutic agent is formulated in a buffer comprising a compound of Formula I:wherein:n is an integer from 2-8; X1 is a cholic acid group or deoxycholic acid group; and X2 and X3 are each independently selected from the group consisting of a cholic acid group, a deoxycholic acid group, and a saccharide group, wherein the saccharide group is selected from the group consisting of pentose monosaccharide groups, hexose monosaccharide groups, pentose-pentose disaccharide groups, hexose-hexose disaccharide groups, pentose-hexose disaccharide groups, and hexose-pentose disaccharide groups; and wherein at least one of X2 and X3 is a saccharide group.

The invention relates to bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free of all moieties of animal origin and free of pyrogenic moieties.

The present invention provides antimicrobial solutions that in certain cases comprise a biguanide and a glycol ether and, in some cases, optionally also includes combinations of at least one an alcohol, at least one chelator, glycerol, deoxycholate, and / or at least one alkylpolyglucoside. In certain aspects the invention comprises a biguanide and deoxycholate or a combination of chelator, ethanol, and alkylpolyglucoside. Also provided are methods for rapidly killing and / or reducing bacteria, fungi, or virus from surfaces, for example, including surfaces of indwelling medical devices and organic surfaces such as skin and sutures, and inorganic surfaces such as medical equipment, pipelines etc.

The invention discloses an amphipathic chitosan derivative PAMAM-Cs-DCA (Poly(amido amine)-chitosan-deoxycholic acid). The PAMAM-Cs-DCA is prepared by sequentially grafting a PAMAM unit and a deoxycholic acid unit on a main chain of chitosan by click chemical reaction and amidation reaction. The preparation method has mild reaction conditions, high efficiency and selectivity. The invention also discloses an application of the amphipathic chitosan derivative in preparing an anticancer drug carrier: the amphipathic chitosan derivative forms nanomicelle which takes the PAMAM unit and chitosan asa hydrophilic shell and takes the DCA unit as a hydrophobic core by self assembly in a water solution, wherein hydrophobic anticancer drugs can be coated in the core, and the shell can be compounded with pDNA (plasmid deoxyribonucleic acid) to realize co-transmission of the drugs and genes. Due to the unique molecular structure, the amphipathic chitosan derivative has potential application valuesin the fields of gene therapy, controlled release of drugs, tissue engineering and the like.

The present invention relates to a group of biomarkers for diagnosing AD in a subject or determining the risk of developing AD in a subject, said diagnostic markers being cholic acid, chenodeoxycholic acid, allocholic acid, indole- 3‑Lactic acid and tryptophan. The present invention also provides the application of the above diagnostic markers in the preparation of differential diagnosis reagents for Alzheimer's disease and a kit. Through the method of plasma sample collection → plasma sample pretreatment → ultra-high performance liquid chromatography mass spectrometry analysis, the plasma fingerprint analysis of AD patients, MCI patients, Ctrl and NDC populations is used to detect the contents of the above five diagnostic markers, so as to apply In the preparation of products related to the diagnosis and efficacy evaluation of Alzheimer's disease. The markers can be used for early evaluation of Alzheimer's disease, with high accuracy, fast detection speed, low cost, small trauma, and easy acceptance by patients, providing a scientific and effective treatment plan for Alzheimer's disease, which has a good application prospects.

The invention relates to a soluble microneedle patch and a preparation method thereof. The soluble microneedle patch comprises a substrate and a needle body on the substrate, the needle body comprises the following components: a high-molecular polymer framework material, polypeptide or protein drugs, a penetration enhancer and a stabilizer; the substrate comprises the high-molecular polymer framework material; the penetration enhancer is at least one of 15-hydroxystearic acid polyethylene glycol ester, Tween 80, deoxycholate, nicotinamide and amino acid. The microneedle patch is used for delivering polypeptide or protein drugs, the intradermal release and permeation speed of the polypeptide or protein drugs is obviously improved, the concentration of the polypeptide or protein drugs entering blood circulation is obviously increased, and the in-vivo bioavailability of the polypeptide or protein drugs after being delivered and administered through the microneedle is improved.

The invention discloses a method for purifying sodium glycochenodeoxycholate, comprising the following steps: S1, dissolving crude sodium glycochenodeoxycholate in an inorganic acid solution, filtering, washing with water, and drying to obtain glycochenodeoxycholate Crude cholic acid; S2, dissolving the crude glycochenodeoxycholic acid obtained in S1 in an eluent to obtain a crude glycochenodeoxycholic acid solution. Composed of potassium hydrogen buffer solution and acetonitrile; S3, put the crude glycochenodeoxycholic acid solution obtained in S2 on the chromatography column, elute, collect the glycochenodeoxycholic acid eluent with a purity >98% detected by HPLC, concentrate, Washing with water and drying; S4, dissolving the dried product of S3 in a solvent, adding sodium hydroxide solution, and concentrating to obtain glycochenodeoxycholic acid sodium salt with a purity >98% as detected by HPLC. The purification method of the present invention is simple in operation, stable and reliable, and can prepare sodium glycochenodeoxycholate with a purity greater than 98% in large quantities.