Full-automatic oral gastrointestinal in-vitro simulation system

Abstract

The invention discloses a full-automatic oral, gastrointestinal and in-vitro simulation system which comprises at least one oral, gastrointestinal and in-vitro continuous simulation device. The oral gastrointestinal in-vitro continuous simulation device comprises: an oral cavity simulation unit, which comprises an oral cavity reactor; the stomach simulation unit comprises a stomach reactor, and the stomach simulation unit is connected with the oral cavity simulation unit; the intestinal tract simulation unit comprises an intestinal tract reactor, and the intestinal tract simulation unit is connected with the stomach simulation unit; the front liquid unit comprises at least six liquid tanks, and the front liquid unit is respectively connected with the oral cavity simulation unit, the stomach simulation unit and the intestinal tract simulation unit. The system can simulate the temperature and pH environment of a digestive system, and realizes a series of functions of sample transfer of an oral cavity-stomach-intestinal tract simulation vessel, accurate sample adding of oral cavity saliva, gastric juice, intestinal juice and the like, time setting automatic sampling, one-key drainage (pipeline cleaning), automatic cleaning (reactor cleaning) and the like.

Description

technical field [0001] The invention belongs to the technical field of biology, and in particular relates to a fully automatic orogastric in vitro simulation system. Background technique [0002] The bioavailability study of nutrients in food can determine the ability of nutrients to be absorbed by the body, which is an important research content in the field of nutrition science. Bioavailability research is usually carried out through animal or human in vivo experiments, but the research time is long, the cost is high, and there are certain risks and ethical and moral issues in human in vivo experiments, and there are few studies in this area at present. Another research method is to simulate the preparation of human digestive juices, such as saliva, gastric juice, intestinal juice, etc., and the related digestive processes of the human digestive tract, such as the mouth, esophagus, stomach and small intestine. Add the food to be tested into the digestive juice, and react ...

AI Technical Summary

Problems solved by technology

[0003] By simulating the digestion process of food in the human gastrointestinal tract and measuring the amount of active ingredients in the food released into the gastric juice or intestinal juice in the gastrointestinal tract, the potential absorption capacity of the active ingredients in the food can be evaluated, but the static gastrointestinal model is usually used at present, using RC -8-type drug dissolution apparatus small cup method for manual simulation, but the artificial mouth gastrointestinal simulation experiment is cumbersome and complicated, time-consuming and labor-intensive, and it is difficult to accurately control the reaction conditions of each link

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