Fluorescent molecular probe with aggregation-induced emission characteristic as well as preparation method and application of fluorescent molecular probe

Abstract

The invention provides a fluorescent molecular probe with aggregation-induced emission characteristics as well as a preparation method and application of the fluorescent molecular probe. The structural formula of the fluorescent molecular probe with the aggregation-induced emission characteristic is shown in the specification. The preparation method of the fluorescent molecular probe comprises the following steps: carrying out first reaction by using 2-aminobenzenethiol and 4-hydroxybenzaldehyde, and carrying out first post-treatment to obtain 4-(benzo [d] thiazole-2-yl) phenol; the 5-(benzo [d] thiazole-2-yl)-2-hydroxybenzaldehyde and hexamethylenetetramine are subjected to a second reaction, and second post-treatment is performed to obtain 5-(benzo [d] thiazole-2-yl)-2-hydroxybenzaldehyde; and carrying out a third reaction with 2-hydrazinopyridine, and carrying out a third post-treatment to obtain the fluorescent molecular probe. The fluorescent molecular probe is used for specifically detecting Al < 3 + >. The fluorescent molecular probe provided by the invention chemically reacts with Al < 3 + > to generate a fluorescent substance with optical properties, so that blue fluorescence is emitted under a specific excitation wavelength, and the purpose of specifically detecting Al < 3 + > is achieved.

Description

technical field [0001] The present application relates to the field of analytical chemistry, in particular to a fluorescent molecular probe with aggregation-induced emission characteristics and its preparation method and application. Background technique [0002] Aluminum is the third most abundant element on the earth's crust and is widely used in daily life, such as utensils, food additives, construction equipment, water purification, pharmaceutical products, etc. However, Al 3+ As a non-essential toxic element in a living system, excessive accumulation can lead to a variety of physiological and biochemical problems, such as Parkinson's disease, Alzheimer's disease, gastric cancer, amyotrophic lateral sclerosis, etc. In addition, acid rain-induced water-soluble Al 3+ Caused severe damage to growing plants and the environment. Therefore, to develop an effective trace detection Al 3+ The method is of great significance to human health and environmental protection. [00...

AI Technical Summary

Problems solved by technology

However, despite Al 3+ Ions are widely present in aqueous environments, but most of the currently reported probes need to detect Al in organic solvent media. 3+ , the poor water solubility of the probe seriously hinders its further application in the environment and biological systems

Images