Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Fluorescent molecular probe with aggregation-induced emission characteristic as well as preparation method and application of fluorescent molecular probe

A technology of aggregation-induced emission and fluorescent molecular probes, which is applied in the field of analytical chemistry, can solve problems such as hindering applications and poor water solubility of probes, and achieve the effect of easy operation

Active Publication Date: 2022-05-13
HUNAN PROVINCIAL TUMOR HOSPITAL +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite Al 3+ Ions are widely present in aqueous environments, but most of the currently reported probes need to detect Al in organic solvent media. 3+ , the poor water solubility of the probe seriously hinders its further application in the environment and biological systems

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Fluorescent molecular probe with aggregation-induced emission characteristic as well as preparation method and application of fluorescent molecular probe
  • Fluorescent molecular probe with aggregation-induced emission characteristic as well as preparation method and application of fluorescent molecular probe
  • Fluorescent molecular probe with aggregation-induced emission characteristic as well as preparation method and application of fluorescent molecular probe

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] This example provides a fluorescent molecular probe with aggregation-induced emission characteristics and its preparation method, and its synthesis route is as follows:

[0044]

[0045] Its specific preparation method is as follows:

[0046] 1. Synthesis of 4-(benzo[d]thiazol-2-yl)phenol

[0047] Add 18.78g (150mmol) of 2-aminobenzenethiol and 18.32g (150mmol) of 4-hydroxybenzaldehyde into 150mL of anhydrous DMF, and then add 24.52g (129mmol) of pyrosulfite, and react at 120°C for 4-6 hours.

[0048] The reaction mixture was cooled to room temperature, then poured into 1L of cold water, a large amount of white solid precipitated, and then the solid was filtered and vacuum-dried to obtain 28.8 g of white solid powder 4-(benzo[d]thiazol-2-yl)phenol, producing The rate is 84.5%.

[0049] 2. Synthesis of 5-(benzo[d]thiazol-2-yl)-2-hydroxybenzaldehyde

[0050] Dissolve 5.00g (22mmol) of 4-(benzo[d]thiazol-2-yl)phenol in 120mL of trifluoroacetic acid solution, slowly a...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a fluorescent molecular probe with aggregation-induced emission characteristics as well as a preparation method and application of the fluorescent molecular probe. The structural formula of the fluorescent molecular probe with the aggregation-induced emission characteristic is shown in the specification. The preparation method of the fluorescent molecular probe comprises the following steps: carrying out first reaction by using 2-aminobenzenethiol and 4-hydroxybenzaldehyde, and carrying out first post-treatment to obtain 4-(benzo [d] thiazole-2-yl) phenol; the 5-(benzo [d] thiazole-2-yl)-2-hydroxybenzaldehyde and hexamethylenetetramine are subjected to a second reaction, and second post-treatment is performed to obtain 5-(benzo [d] thiazole-2-yl)-2-hydroxybenzaldehyde; and carrying out a third reaction with 2-hydrazinopyridine, and carrying out a third post-treatment to obtain the fluorescent molecular probe. The fluorescent molecular probe is used for specifically detecting Al < 3 + >. The fluorescent molecular probe provided by the invention chemically reacts with Al < 3 + > to generate a fluorescent substance with optical properties, so that blue fluorescence is emitted under a specific excitation wavelength, and the purpose of specifically detecting Al < 3 + > is achieved.

Description

technical field [0001] The present application relates to the field of analytical chemistry, in particular to a fluorescent molecular probe with aggregation-induced emission characteristics and its preparation method and application. Background technique [0002] Aluminum is the third most abundant element on the earth's crust and is widely used in daily life, such as utensils, food additives, construction equipment, water purification, pharmaceutical products, etc. However, Al 3+ As a non-essential toxic element in a living system, excessive accumulation can lead to a variety of physiological and biochemical problems, such as Parkinson's disease, Alzheimer's disease, gastric cancer, amyotrophic lateral sclerosis, etc. In addition, acid rain-induced water-soluble Al 3+ Caused severe damage to growing plants and the environment. Therefore, to develop an effective trace detection Al 3+ The method is of great significance to human health and environmental protection. [00...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D417/12C09K11/06G01N21/64
CPCC07D417/12C09K11/06G01N21/6428C09K2211/1037C09K2211/1029Y02P20/55
Inventor 周慧俊甘亚兵刘振洋李婷尹鹏陈攀
Owner HUNAN PROVINCIAL TUMOR HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com