Marker for ovarian cancer and application thereof

Abstract

The invention belongs to the technical field of medical biology, and particularly relates to an ovarian cancer marker and application thereof. The invention proposes that the expression level of PRPF6 in ovarian cancer is closely related to FIGO staging and is irrelevant to age, differentiation degree and lymph node metastasis for the first time. The expression levels of the PRPF6 gene and the encoded protein thereof in the ovarian cancer drug-resistant cells / tissues are detected through PCR, immunohistochemistry and other methods, high expression of the PRPF6 in the drug-resistant cells / tissues is found, and it is clear that the PRPF6 can be used as the ovarian cancer paclitaxel drug-resistant marker. By inhibiting the expression level of the PRPF6, the drug resistance of paclitaxel can be inhibited, the invasion and migration of ovarian cancer cells can be reduced, cell apoptosis can be induced, and tumor growth can be inhibited, so that the PRPF6 inhibitor can be used as a potential target spot for the paclitaxel chemotherapy drug resistance treatment of the ovarian cancer, and a reference basis is provided for clinical diagnosis and treatment of the chemotherapy drug resistance type ovarian cancer. The method has wide application prospects and huge potential social benefits.

Description

technical field

[0001] The invention belongs to the technical field of medicine and biology, and in particular relates to a marker of ovarian cancer and its application. Background technique

[0002] Ovarian cancer (OC) is one of the female malignancies with high morbidity and mortality worldwide. Since the early clinical manifestations of ovarian cancer patients have no obvious specificity, the early diagnosis rate in our country is low, and most of the ovarian cancer patients are in the advanced stage, although the 5-year survival rate is very low despite cellular decompression combined with radiotherapy and chemotherapy. Paclitaxel is currently a widely used anti-tumor chemotherapy drug. However, long-term treatment can make tumor cells resistant to it, which is the main reason for the failure of chemotherapy. Therefore, in-depth research on ovarian cancer chemotherapy resistance, finding effective and reliable drug resistance markers, and developing related drugs to re...

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