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Biomarker and diagnostic kit for distinguishing prostatitis and prostatic cancer

A technology for biomarkers and prostate cancer, applied in the field of biomarkers and diagnostic kits for distinguishing prostate cancer and prostatitis, which can solve the problems of differentiation and achieve high diagnostic accuracy

Pending Publication Date: 2022-05-13
广州市番禺区中心医院
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these early symptoms are similar to the symptoms of prostatitis, another common male prostate disease, but the current clinical diagnostic methods, including digital rectal examination, serum PSA, and transrectal prostate ultrasound, are difficult to distinguish between the two diseases

Method used

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  • Biomarker and diagnostic kit for distinguishing prostatitis and prostatic cancer
  • Biomarker and diagnostic kit for distinguishing prostatitis and prostatic cancer
  • Biomarker and diagnostic kit for distinguishing prostatitis and prostatic cancer

Examples

Experimental program
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Embodiment 1

[0028] In this embodiment, the content of organic acid metabolites in the venous blood serum of patients with prostatitis and prostate cancer is detected, specifically as follows:

[0029] 1. Subject inclusion criteria

[0030] Inclusion criteria for patients with prostatitis (prostatitis group): 1) with typical clinical symptoms: urgency, frequency, and dysuria; 2) with abnormal results of routine examination of prostatic fluid; 3) with no abnormalities in liver and kidney function, and no medication treatment or surgical resection.

[0031] Inclusion criteria for prostate cancer patients (PCa group): 1) Serum prostate-specific antigen (PSA), digital rectal examination, prostate ultrasound, multi-parameter magnetic resonance scan and other examinations, with a clear pathological diagnosis of prostate biopsy; no other systemic diseases, No history of other malignant tumors; 2) The staging of prostate cancer refers to the TNM staging system established by the American Cancer S...

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Abstract

The invention relates to a biomarker and a diagnostic kit for distinguishing prostatitis and prostatic cancer. The biomarker is selected from at least one of citric acid, L-pyroglutamic acid, DL-3-phenyl lactic acid, ethyl malonic acid, 3-hydroxy-3-methyl glutamic acid and hippuric acid. The kit comprises a reagent for quantitatively detecting the biomarker. The biomarker has differential expression in bodies of patients with prostatitis and prostatic cancer, and the difference has statistical significance. ROC curve analysis is further carried out, the result shows that the biomarker can serve as a specific marker for distinguishing prostatitis and prostatic cancer patients, the accuracy is high (AUC ranges from 0.7 to 0.9), especially citric acid, the AUC reaches up to 0.926, and it is indicated that the diagnosis accuracy is high. The invention provides a new biomarker for identifying prostatitis and prostatic cancer patients, and has the advantages of convenience in sampling, rapidness and high efficiency in detection and the like when being used for clinical auxiliary diagnosis.

Description

technical field [0001] The invention relates to the technical field of medical testing, in particular to a biomarker and a diagnostic kit for distinguishing prostate cancer and prostatitis. Background technique [0002] Prostate cancer (PCa) ranks sixth in the incidence of malignant tumors in men, and the incidence increases with age, gradually increasing after the age of 55, and the peak age is 70-80 years old. Prostate cancer is a very slow-growing cancer that is not easy to detect in the early stages of the disease, but can become more serious once it begins to grow or spread rapidly. Patients with early-stage prostate cancer (the tumor is only located within the prostate capsule) can achieve good therapeutic effects and even be cured by radical surgery or radical radiotherapy. Therefore, early diagnosis and early treatment are very important for prostate cancer patients. [0003] The symptoms of early prostate cancer are not obvious. As the prostate gland gradually enl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/04
CPCG01N30/04G01N2030/045
Inventor 何金花罗文峰申健韩泽平谢芳梅郭仲辉罗欣黎毓光
Owner 广州市番禺区中心医院
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