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Method for extracting active ingredients for relieving non-alcoholic fatty liver disease and preparing composition of active ingredients for relieving non-alcoholic fatty liver disease

A non-alcoholic, liver extract technology, applied in the field of the extraction of active ingredients for relieving non-alcoholic fatty liver and the preparation of compositions thereof

Pending Publication Date: 2022-05-17
上海朗泰凯尔生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are no approved drug therapies for the treatment of nonalcoholic fatty liver disease

Method used

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  • Method for extracting active ingredients for relieving non-alcoholic fatty liver disease and preparing composition of active ingredients for relieving non-alcoholic fatty liver disease
  • Method for extracting active ingredients for relieving non-alcoholic fatty liver disease and preparing composition of active ingredients for relieving non-alcoholic fatty liver disease
  • Method for extracting active ingredients for relieving non-alcoholic fatty liver disease and preparing composition of active ingredients for relieving non-alcoholic fatty liver disease

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A composition for relieving non-alcoholic fatty liver in this embodiment, including: bovine liver extract, Chinese medicine extract, active peptide and probiotics, Chinese medicine extract includes kudzu root extract and cassia seed extract, active peptide includes soybean active Peptides and corn active peptides, probiotics include Bifidobacterium lactis, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium bifidum lyophilized powder, calculated by mass percentage, the bovine liver extract, The mass percentage of Chinese medicine extracts, active peptides and probiotics is 1:4:2:0.1.

[0035] The preparation method of this embodiment composition:

[0036] 1) Preparation of kudzu root extract

[0037] Get Pueraria root powder 100g, add 500g water ultrasonic extraction 1 hour, extract is freeze-dried; Add the 30% ethanol aqueous solution of 5 times weight of extract to dissolve, use the macroporous adsorption resin column that fills...

Embodiment 2

[0075] The difference between this example and Example 1 is that a composition for relieving non-alcoholic fatty liver in this example includes: bovine liver extract, kudzu root extract, soybean active peptide, Bifidobacterium lactis, para Lactobacillus casei and Lactobacillus plantarum, calculated by mass percentage, the mass percentage of the bovine liver extract, kudzu root extract, soybean active peptide, Bifidobacterium lactis, Lactobacillus paracasei, and Lactobacillus plantarum is 1:6:2 :0.12.

[0076] The preparation method of this embodiment composition:

[0077] 1) Preparation of kudzu root extract

[0078] Take 100g of pueraria root powder, add 200g of water for ultrasonic extraction for 1 hour, and freeze-dry the extract; add 5 times the weight of the extract in 30% ethanol aqueous solution to dissolve, and absorb with a macroporous adsorption resin column filled with HP870. The column volume of deionized water, 10% ethanol, and 30% ethanol was used to wash away ...

Embodiment 3

[0089] The difference between this example and Example 2 is that a composition for relieving non-alcoholic fatty liver in this example includes: bovine liver extract, cassia seed extract, corn active peptide, Lactobacillus plantarum, rhamnos Lactobacillus sugar, Bifidobacterium bifidum, calculated by mass percentage, bovine liver extract, cassia seed extract, corn active peptide, Lactobacillus plantarum freeze-dried powder, Lactobacillus rhamnosus freeze-dried powder, Bifidobacterium bifidum freeze-dried powder The mass percentage of dry powder is 1:11:2:0.05.

[0090] The preparation method of this embodiment composition:

[0091] 1) Preparation of Semen Cassiae Extract

[0092] Take 100g of cassia seed, grind it, add 300g of water and ultrasonically extract it for 1 hour, and freeze-dry the extract; add 30% ethanol aqueous solution with 5 times the weight of the extract to dissolve, and absorb it with a macroporous adsorption resin column filled with polyamide resin. After ...

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Abstract

The invention belongs to the technical field of medicine formula preparation, and particularly relates to extraction of an active ingredient for relieving non-alcoholic fatty liver and a preparation method of a composition of the active ingredient. The feed additive comprises the following components in percentage by mass: cattle liver extract, traditional Chinese medicine extract, active peptide and probiotics, and the mass ratio of the cattle liver extract to the traditional Chinese medicine extract to the active peptide to the probiotics is 1: (2-11): 2: (0.05-0.14). According to the invention, the animal liver extract, the traditional Chinese medicine extract and the active peptide are extracted and optimized by a simple method, and the probiotics with the activity of improving intestinal immunity and relieving non-alcoholic fatty liver are screened; and then combining the animal liver extract, the traditional Chinese medicine extract, the active peptide and the probiotics to obtain the composition capable of improving the intestinal immunity and relieving the non-alcoholic fatty liver disease. The drug effect of the composition is better than that of the single use of the animal liver extract, the traditional Chinese medicine extract, the active peptide or the probiotics.

Description

technical field [0001] The invention belongs to the technical field of preparation of pharmaceutical formulas, and in particular relates to a method for extracting active ingredients for alleviating non-alcoholic fatty liver and a preparation method of the composition thereof. Background technique [0002] Nonalcoholic fatty liver disease is a metabolic stress-induced liver injury closely related to insulin resistance and genetic susceptibility. The disease spectrum includes nonalcoholic hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver affects nearly 1 / 4 of the general population and nearly 90% of morbidly obese patients worldwide, and has been recognized as the leading cause of chronic liver disease in adults and children. Non-alcoholic fatty liver disease is recognized as one of the early lesions of liver fibrosis and cirrhosis as well as middle and end-stage liver diseases. Histological studies have found...

Claims

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Application Information

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IPC IPC(8): A61K35/407A61K9/48A61K38/01A61K36/899A61P1/16A61K35/745A61K35/747
CPCA61K35/407A61K36/488A61K36/482A61K35/745A61K35/747A61K36/48A61K36/899A61K38/011A61K9/4866A61P1/16A61K38/00A61K2300/00Y02A50/30
Inventor 刘杰王尔一陈能花刘百联罗敏罗丹张健润
Owner 上海朗泰凯尔生物技术有限公司
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