Atomized liquid for preventing and treating influenza as well as preparation method and administration method thereof
A drug delivery method and an atomized liquid technology, applied in the field of traditional Chinese medicine, can solve the problems of not paying attention to the taste, so as to improve the curative effect, avoid the liver first-pass effect, and improve the synergistic antiviral effect
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preparation example Construction
[0064] The preparation method of the perilla leaf extract is as follows: fresh perilla leaves are used as raw materials, washed with 0.3-0.8% NaCl solution, and then used for later use; fresh perilla leaves are added in a ratio of 1:15-30 to a material-to-liquid ratio, boiled, and then cooled to 60 The distilled water at ~70°C was placed in a multifunctional wall breaker, crushed at 10,000 rpm for 3 minutes, intermittently for 2 minutes, and circulated for 3 times, then centrifuged at 4,000 rpm for 10 minutes, and the supernatant was collected and concentrated under reduced pressure to a relative density of 1.10 to 1.15. , pre-frozen at -50°C for 24h and freeze-dried for 72h to obtain perilla leaf extract. After testing, the content of rosmarinic acid in the perilla leaf extract was 231.5±3.49 mg / g.
[0065]The preparation method of Dendrobium officinale extract is as follows: fresh Dendrobium officinale is used as raw material, washed with 0.3-0.8% NaCl solution, cut into sma...
Embodiment example 1
[0097] 4. Implementation Case 1: Preparation of Atomized Liquid for Prevention and Treatment of Influenza and Application of Spray Administration
[0098] A kind of atomized liquid for preventing and treating influenza, its weight percentage composition is: 5% of perilla leaf extract, 1% of Dendrobium officinale extract, 0.05% of commercially available Luo Han Guo extract, 0.025% of cooling agent (WS-23), Hawthorn flavor edible essence 0.5%, potassium sorbate 0.05%, propylene glycol 8%, ethanol 5%, vegetable glycerin 5%, and the balance is distilled water.
[0099] Mix the perilla leaf extract, Dendrobium officinale extract, Luo Han Guo extract, and potassium sorbate evenly, add sterilized distilled water, stir until dissolved, and filter with a 0.45 μm membrane to obtain solution A; add propylene glycol to the cooling agent , ethanol until completely dissolved, then add edible flavor, and mix well to obtain solution B; pour solution A into solution B, stir evenly to obtain a ...
Embodiment example 2
[0100] V. Implementation Case 2: Preparation of Atomized Liquid for Influenza Prevention and Treatment and Application of Ultrasonic Atomization
[0101] A kind of atomized liquid for preventing and treating influenza, its weight percentage composition is: 5% of perilla leaf extract, 1% of Dendrobium officinale extract, 0.1% of commercially available Luo Han Guo extract, cooling agent (WS-23:WS-5 It is 2:1) 0.05%, lemon flavored food essence 2%, potassium sorbate 0.05%, propylene glycol 10%, and the balance is distilled water.
[0102] Mix the perilla leaf extract, Dendrobium officinale extract, Luo Han Guo extract, and potassium sorbate evenly, add sterilized distilled water, stir until dissolved, and filter with a 0.45 μm membrane to obtain solution A; add propylene glycol to the cooling agent To be completely dissolved, then add edible essence, and mix well to obtain solution B; pour solution A into solution B, stir evenly to obtain a transparent solution, after mixing even...
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