Atomized liquid for preventing and treating influenza as well as preparation method and administration method thereof

A drug delivery method and an atomized liquid technology, applied in the field of traditional Chinese medicine, can solve the problems of not paying attention to the taste, so as to improve the curative effect, avoid the liver first-pass effect, and improve the synergistic antiviral effect

Active Publication Date: 2022-05-27
NINGBO YILAN YASI SKIN CARE PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Traditional Chinese medicine is mainly administered orally. The disadvantage is that it does not pay attention to the taste...

Method used

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  • Atomized liquid for preventing and treating influenza as well as preparation method and administration method thereof
  • Atomized liquid for preventing and treating influenza as well as preparation method and administration method thereof
  • Atomized liquid for preventing and treating influenza as well as preparation method and administration method thereof

Examples

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preparation example Construction

[0064] The preparation method of the perilla leaf extract is as follows: fresh perilla leaves are used as raw materials, washed with 0.3-0.8% NaCl solution, and then used for later use; fresh perilla leaves are added in a ratio of 1:15-30 to a material-to-liquid ratio, boiled, and then cooled to 60 The distilled water at ~70°C was placed in a multifunctional wall breaker, crushed at 10,000 rpm for 3 minutes, intermittently for 2 minutes, and circulated for 3 times, then centrifuged at 4,000 rpm for 10 minutes, and the supernatant was collected and concentrated under reduced pressure to a relative density of 1.10 to 1.15. , pre-frozen at -50°C for 24h and freeze-dried for 72h to obtain perilla leaf extract. After testing, the content of rosmarinic acid in the perilla leaf extract was 231.5±3.49 mg / g.

[0065]The preparation method of Dendrobium officinale extract is as follows: fresh Dendrobium officinale is used as raw material, washed with 0.3-0.8% NaCl solution, cut into sma...

Embodiment example 1

[0097] 4. Implementation Case 1: Preparation of Atomized Liquid for Prevention and Treatment of Influenza and Application of Spray Administration

[0098] A kind of atomized liquid for preventing and treating influenza, its weight percentage composition is: 5% of perilla leaf extract, 1% of Dendrobium officinale extract, 0.05% of commercially available Luo Han Guo extract, 0.025% of cooling agent (WS-23), Hawthorn flavor edible essence 0.5%, potassium sorbate 0.05%, propylene glycol 8%, ethanol 5%, vegetable glycerin 5%, and the balance is distilled water.

[0099] Mix the perilla leaf extract, Dendrobium officinale extract, Luo Han Guo extract, and potassium sorbate evenly, add sterilized distilled water, stir until dissolved, and filter with a 0.45 μm membrane to obtain solution A; add propylene glycol to the cooling agent , ethanol until completely dissolved, then add edible flavor, and mix well to obtain solution B; pour solution A into solution B, stir evenly to obtain a ...

Embodiment example 2

[0100] V. Implementation Case 2: Preparation of Atomized Liquid for Influenza Prevention and Treatment and Application of Ultrasonic Atomization

[0101] A kind of atomized liquid for preventing and treating influenza, its weight percentage composition is: 5% of perilla leaf extract, 1% of Dendrobium officinale extract, 0.1% of commercially available Luo Han Guo extract, cooling agent (WS-23:WS-5 It is 2:1) 0.05%, lemon flavored food essence 2%, potassium sorbate 0.05%, propylene glycol 10%, and the balance is distilled water.

[0102] Mix the perilla leaf extract, Dendrobium officinale extract, Luo Han Guo extract, and potassium sorbate evenly, add sterilized distilled water, stir until dissolved, and filter with a 0.45 μm membrane to obtain solution A; add propylene glycol to the cooling agent To be completely dissolved, then add edible essence, and mix well to obtain solution B; pour solution A into solution B, stir evenly to obtain a transparent solution, after mixing even...

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Abstract

The invention discloses atomized liquid for preventing and treating influenza as well as a preparation method and an administration method of the atomized liquid. The atomized liquid comprises the following components in percentage by weight: 3-10% of a perilla leaf extract, 0.5-2% of a dendrobium officinale extract, 0.05-2% of a momordica grosvenori extract, 0-0.2% of a cooling agent, 0.5-20% of edible essence, 0-0.05% of potassium sorbate, 5-30% of propylene glycol, 0-6% of ethanol, 0-50% of plant glycerin and the balance of distilled water. The administration method of the atomized liquid comprises spray administration, ultrasonic atomization administration and electronic heating atomization administration, the atomized liquid is inhaled through the oral cavity, the medicine is highly dispersed, the atomized liquid is absorbed through the oral cavity and upper respiratory tract mucosa, the liver first-pass effect can be avoided, the dosage is reduced, the curative effect is improved, and the atomized liquid is very effective, safe and reliable for flu prevention and initial treatment; according to the administration method of the atomized liquid, the drug effect, the taste, the fragrance and the smoke can be integrated, the compliance of medication is improved, the experience feeling of traditional Chinese medicine products is better improved, and popularization of traditional Chinese medicine is facilitated.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an atomized liquid for preventing and treating influenza and a preparation method and administration method thereof. Background technique [0002] Influenza is mainly caused by the virus entering the body from the nose and mouth. Its contagiousness is significantly stronger than that of wind-heat colds. According to WHO reports, there are about 250,000 to 500,000 deaths caused by influenza each year, and about 3 to 5 million cases of severe cases. The human health and socioeconomic toll of influenza outbreaks remains a global public health problem. At present, anti-influenza virus drugs mainly include: neuraminidase inhibitors (NAIs), M2 ion channel blockers and traditional Chinese medicines. Among them, neuraminidase is a glycoprotein on the surface of influenza virus and is considered to be an important target for the development of antiviral drugs, so NA...

Claims

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Application Information

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IPC IPC(8): A61K9/72A61K36/8984A61K47/46A61P31/16
CPCA61K9/12A61K9/006A61K9/0078A61K36/535A61K36/8984A61K36/42A61K47/46A61P31/16A61K2236/331A61K2236/51A61K2236/53A61K2300/00Y02A50/30
Inventor 钱旭利刘利萍叶琪珺
Owner NINGBO YILAN YASI SKIN CARE PROD CO LTD
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