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Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating xerophthalmia

A dry eye syndrome and glycopeptide technology, applied in the field of biomedicine, can solve the problem of prevention or treatment of dry eye syndrome with Lycium barbarum glycopeptide, and achieve the effect of safe consumption and significant effect

Pending Publication Date: 2022-06-07
NINGXIA QIPEPTIDE TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no report on the prevention or treatment of dry eye syndrome with Lycium barbarum glycopeptide

Method used

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  • Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating xerophthalmia
  • Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating xerophthalmia
  • Application of lycium barbarum glycopeptide in preparation of medicine for preventing or treating xerophthalmia

Examples

Experimental program
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Effect test

Embodiment

[0049] Example: Investigate the therapeutic effect of Lycium barbarum glycopeptide on dry eye model mice

[0050] 1. Experimental materials

[0051] 1.1 Experimental animals

[0052] This experiment selected SPF grade C57 / BL6 mice, female, 6 weeks old, body weight 20±2g, provided by Beijing Huafukang Biotechnology Co., Ltd. (license number: SCXK (Beijing) 2020-0004). Formal review and approval by the Animal Care and Ethics Committee of Zhongshan Eye Center (ethics batch number: 2021-013).

[0053] 1.2 Test reagents and their sources

[0054] Choline hydrobromide powder was purchased from Sigma Company in the United States, and its product number was R427039-250mg; fluorescein sodium ophthalmic test strip was purchased from Tianjin Jingming New Technology Development Co., Ltd., whose production batch number was 20211224; one-step TUNEL cell apoptosis The detection kit was purchased from Shanghai Beyotime Biotechnology Co., Ltd., and its product number was BWN-Beyotime-C1088....

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Abstract

The invention belongs to the technical field of biological medicine, and particularly relates to application of lycium barbarum glycopeptide to preparation of medicine for preventing or treating xerophthalmia or corneal injury. Experimental results show that oral administration of the Chinese wolfberry glycopeptide has the efficacy of preventing and treating the xerophthalmia, and the Chinese wolfberry glycopeptide does not influence normal tear secretion, but reduces and adjusts abnormal tear secretion to a normal level, so that the principle of the treatment effect of the Chinese wolfberry glycopeptide on the xerophthalmia is safer, the effect is more remarkable, and the Chinese wolfberry glycopeptide is safer to eat. As a traditional Chinese medicinal material extraction product, the Chinese wolfberry glycopeptide can be effectively used for preventing and treating xerophthalmia, has a prospect of being developed into oral medicines for preventing and treating xerophthalmia, provides more treatment choices for clinically preventing or treating xerophthalmia, and has important social benefits and economic values.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the use of lycium barbarum glycopeptide in the preparation of a medicament for preventing or treating dry eye. Background technique [0002] The healthy eye surface is covered with a tear film structure composed of mucin, aqueous tears and oil secreted by the accessory glands of the eyeball. ; When the dynamic balance of the tear film components covering the surface of the eyeball is disrupted and cannot be replenished and repaired in time, dry eye syndrome will be induced. [0003] The most intuitive symptoms of dry eye are the changes in the components of the tear film on the ocular surface, which come from the disease or morphological, structural and functional changes of the corresponding accessory glands of the eyeball. Therefore, the disease classification of dry eye is diverse, and the main ones are divided into tear-deficient dry eye and water-deficient dr...

Claims

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Application Information

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IPC IPC(8): A61K38/14A61P27/02A61K31/7048
CPCA61K38/14A61K31/7048A61P27/02A61K2300/00
Inventor 迟玮晏纯苏国辉唐仕波陈建苏于哲雄王金霞樊福
Owner NINGXIA QIPEPTIDE TECH CO LTD
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