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Carboxylate two-photon dye taking fluorene ring as matrix, synthetic method and application

A synthesis method and carboxylate technology, which are applied in the field of fluorescent dyes and two-photon imaging, can solve the problems of high biological toxicity, limited application, low two-photon absorption cross-section, etc., and achieve low biological toxicity, good biocompatibility, and ease of use. retouching effect

Active Publication Date: 2022-06-21
ZHEJIANG UNIV
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  • Abstract
  • Description
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Problems solved by technology

[0004] However, most of the currently commercially available dyes have low two-photon absorption cross-sections.
In addition, commercial mitochondrial labeling dyes represented by MitoTracker have high biological toxicity, which limits their application in live cell staining and in vivo staining.

Method used

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  • Carboxylate two-photon dye taking fluorene ring as matrix, synthetic method and application
  • Carboxylate two-photon dye taking fluorene ring as matrix, synthetic method and application
  • Carboxylate two-photon dye taking fluorene ring as matrix, synthetic method and application

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Embodiment Construction

[0047] Below in conjunction with accompanying drawing and specific embodiment, further illustrate the present invention, should be understood that these embodiments are only for illustrating the present invention and are not intended to limit the scope of the present invention, after having read the present invention, those skilled in the art will understand various aspects of the present invention Modifications in equivalent forms all fall within the scope defined by the appended claims of this application.

[0048] As shown in the figure, the carboxylate two-photon dye with fluorene ring as the parent of the present invention has a chemical name of 2,2'-((((1E,1'E)-(9,9-bis(2- (2-methoxyethoxy)ethyl)-9H-fluorene-2,7-diyl)bis(ethylene-2,1-diyl)bis(4,1-phenylene))bis( Methylamino) sodium diacetate, named FO2, and has the following molecular structure:

[0049]

[0050] The specific synthesis and preparation method of the carboxylate two-photon dye FO of the present inventi...

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Abstract

The invention discloses a carboxylate two-photon dye taking a fluorene ring as a matrix and a synthesis method and application thereof, and the small molecule fluorescent dye has the advantages of good water solubility, cell permeability, excellent two-photon absorption cross section, good mitochondrial recognition and the like, and can be applied to living body mitochondrial labeling.

Description

technical field [0001] The invention belongs to the technical field of fluorescent dyes and two-photon imaging, and in particular relates to the synthesis and application technology of a novel water-soluble two-photon absorption fluorescent dye with mitochondrial recognition ability. Background technique [0002] Mitochondria are the most important energy-supplying organelles in eukaryotic cells. It provides energy to cells by synthesizing adenosine triphosphate through oxidative phosphorylation, and bears about 95% of the energy for cell life activities. In addition, mitochondria are also involved in processes such as cell differentiation, cell information transmission, and cell apoptosis, and can regulate cell growth, cell cycle, etc. Abnormalities of mitochondrial structure or function are closely related to neurodegenerative diseases (such as Parkinson's disease, Alzheimer's disease, etc.), cardiovascular diseases (stroke, etc.), metabolic diseases, and cancer. Therefo...

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Application Information

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IPC IPC(8): C09B23/14C09K11/06G01N21/64A61K49/00C07C227/16C07C229/18
CPCC09B23/141C09K11/06C07C41/30C07C227/08C07F5/025C07C227/16G01N21/6428G01N21/6458A61K49/0032C09K2211/1011C09K2211/1007C07C2603/18C07C43/1747C07C229/18Y02E10/549
Inventor 王绪化何赛灵陈作兵林灵敏斯科龚薇贺泽瑋陈飞鸿王大明陈向锋
Owner ZHEJIANG UNIV
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