Muscle relaxation monitoring instrument-based drug effect evaluation method for muscle relaxation antagonist
A drug efficacy evaluation and monitor technology, which is applied in the field of medicine, can solve the problems of unfavorable pharmacodynamics accurate evaluation, poor repeatability, and many operating procedures, and achieve the advantages of rapid screening and accurate evaluation of drug efficacy, simple evaluation methods, and drug Good effect
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[0023] Example 1 Efficacy evaluation of rocuronium bromide-induced reversal of neuromuscular blockade in guinea pigs
[0024] Quarantine-qualified adult guinea pigs (body weight 400-700 g) were selected, intraperitoneally injected with 30 mg / kg of sodium pentobarbital and 1000 mg / kg of urethane, and fixed on the animal surgical fixation board in supine position. After the trachea of the animal is intubated with a medical catheter, the animal is connected to a ventilator for normal breathing and ventilation. The jugular veins on both sides of the animals were intubated respectively, one vein was used for instillation of the muscle relaxant rocuronium bromide, and the other vein was used for the bolus injection of the candidate muscle relaxant antagonist to be tested. The temperature sensing probe of the TOF-Watch SX muscle relaxation monitor was fixed on the flat skin of the left hind limb of the guinea pig, the acceleration sensing probe was fixed on the skin surface of the ...
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[0027] Example 2 Pharmacodynamic evaluation of vecuronium bromide-induced reversal of canine neuromuscular blockade
[0028] Qualified adult Beagle dogs (weight 8-12 kg) were selected, intravenously injected with 30 mg / kg sodium pentobarbital, and fixed on the animal surgical fixation board in supine position. After the trachea of the animal is intubated with a medical catheter, the animal is connected to a ventilator for normal breathing and ventilation. The jugular veins on both sides of the animals were intubated respectively, one vein was used for instillation of the muscle relaxant vecuronium bromide, and the other vein was used for the bolus injection of the candidate muscle relaxant antagonist to be tested. The temperature sensing probe of the TOF-Watch SX muscle relaxation monitor was fixed on the flat skin of the left hind limb of the dog, the acceleration sensing probe was fixed on the skin surface of the gastrocnemius muscle of the left hind limb of the guinea pig...
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