Muscle relaxation monitoring instrument-based drug effect evaluation method for muscle relaxation antagonist

Abstract

The invention provides a muscle relaxation antagonist efficacy evaluation method based on a muscle relaxation monitor, which comprises the following steps of: anesthetizing an animal for artificial ventilation, generating serial electric signals for four continuous times through the muscle relaxation monitor to stimulate sciatic nerves of the animal so as to obtain a stable stimulation reaction, continuously dripping muscle relaxation medicine to enable the animal to reach a shallow muscle relaxation degree, and continuously dripping the muscle relaxation medicine into the animal. Different doses of drugs to be detected are sequentially given, a dose-effect curve is drawn with the TOFR recovery peak value as the effect dose, and the half effective dose ED50 is calculated. According to the method, the drug effect of the to-be-tested object is tested and evaluated by adopting a uniform evaluation standard, namely the half effective dose taking the TOFR recovery peak value as the effect dose, the pharmacological effect degree of the to-be-tested object for resisting neuromuscular block can be quantitatively reflected, and the smaller the half effective dose is, the better the drug effect is. The evaluation method is simple and convenient, has good repeatability, is beneficial to rapid screening and accurate evaluation of the drug effect of the muscle relaxation antagonist, and has very important significance for preclinical drug effect evaluation.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a method for evaluating the efficacy of a muscle relaxant antagonist based on a muscle relaxant monitor, in particular to a method for evaluating the pharmacodynamics of a drug for reversing the neuromuscular block effect induced by the muscle relaxant. Background technique [0002] With the increase in the number of elderly people, the incidence of various major diseases has also increased rapidly, and the demand for clinical surgical treatment has also increased accordingly. General anesthesia is widely used as an adjuvant method in the surgical process, and millions of people are operated under general anesthesia every year. General anesthesia is generally through drugs or other medical means to suppress the patient's nervous system, showing reversible consciousness, relative analgesia, muscle relaxation and reflex inhibition. The three elements of successful general anesthe...

AI Technical Summary

Problems solved by technology

The two methods have their own advantages and disadvantages. The former is mainly suitable for qualitative evaluation, which more intuitively reflects the recovery time of the body's neuromuscular blockade reversal after drug administration. Drug dose-response relationship

Although the latter has an obvious dose-effect relationship, the measurement of muscle contractility is unstable, the repeatability is poor, and there are many operating procedures, which is not conducive to the accurate evaluation of pharmacodynamics.

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