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Preparation method of flexible wearable sweat glucose electrochemical sensor

A wearable, glucose-based technology, applied in the direction of material electrochemical variables, scientific instruments, instruments, etc., can solve the problems of patients' physical and psychological pain, and cannot realize continuous monitoring, and achieve low detection limit, good tensile performance, and low price Effect

Inactive Publication Date: 2022-06-28
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional portable enzymatic blood glucose meter needs to puncture the finger to collect blood, which is an invasive test, which will cause certain physical and psychological pain to the patient, and cannot achieve continuous monitoring

Method used

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  • Preparation method of flexible wearable sweat glucose electrochemical sensor
  • Preparation method of flexible wearable sweat glucose electrochemical sensor
  • Preparation method of flexible wearable sweat glucose electrochemical sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1. Preparation of spinning solution:

[0019] Add 2 ml of N,N-dimethylacetamide (DMAC) to graphene and polyurethane (mass ratio of 1:5) and mix and stir to obtain a spinning solution.

[0020] 2. Preparation of polydimethylsiloxane:

[0021] In a mass ratio of 10:1, the polydimethylsiloxane prepolymer and the curing agent are mixed, and a crosslinking reaction occurs to form the polydimethylsiloxane.

[0022] 3. Preparation of flexible biosensors:

[0023] (1) Preparation of fiber electrode mold:

[0024] The polydimethylsiloxane prepolymer (PDMS) and the curing agent were mixed in a ratio of 10:1 and then degassed, then spin-coated on a glass slide, placed in an oven for 5 min and taken out. A 1mm capillary column was gently placed on the surface of the incompletely cured PDMS, placed in an oven to dry for 2 hours and taken out. After the PDMS was completely cured, the capillary was taken out, and a thin groove was formed on the surface of the PDMS to obtain a fiber...

Embodiment 2

[0038] Referring to the preparation method of Example 1, the difference is that in the preparation of rGO / PU fibers, the ratio of rGO to PU is adjusted.

[0039] The specific operations are as follows: rGO / PU with ratios of 0, 1:10, 1:5, 1:3, and 1:1 were mixed with 2 mL DMAC to obtain spinning solutions with different ratios.

Embodiment 3

[0041] Referring to the preparation method of Example 1, the difference is that in the preparation of the working electrode, the concentration of Ni / Co-MOF in the Ni-Co MOF dispersion liquid is adjusted.

[0042] The details are as follows: 1.5mg, 3mg, 4.5mg, 6mg, 7.5mg of Ni-Co MOF powders were dissolved in 1 mL of Nafion ethanol solution with a concentration of 1%, and ultrasonicated for 5 minutes at room temperature until different Ni-Co MOF powders were formed. MOF concentration dispersion.

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PUM

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Abstract

The invention discloses a preparation method of a flexible wearable sweat glucose electrochemical sensor, which comprises the following steps: producing rGO / PU fiber by using a simple improved wet spinning technology, and then coating the surface of a working electrode with a Ni-Co MOF nanosheet to prepare a Ni-Co MOF / Ag / rGO / PU (NCGP) fiber electrode; then, a three-electrode system with the NCGP fiber as a working electrode and a water absorption fabric are sewn and fixed on a stretchable polydimethylsiloxane (PDMS) film base material, and the non-enzyme sweat glucose wearable sensor is formed. The electrode manufacturing method is simple and convenient, the price is low, and the electrode has a wide application prospect in the field of real-time monitoring of human health.

Description

technical field [0001] The invention relates to a preparation method of an electrochemical sensor, in particular to a preparation method of a flexible wearable sweat glucose electrochemical sensor. Background technique [0002] Diabetes is one of the most common chronic diseases in humans, and a large number of blood glucose detection devices have been developed. The traditional portable enzymatic blood glucose meter needs to puncture the finger to collect blood, which is an invasive test, which will cause certain physical and psychological pain to the patient, and cannot achieve continuous monitoring. SUMMARY OF THE INVENTION [0003] Purpose of the invention: The present invention aims to provide a painless, continuous and convenient preparation method of a flexible wearable sweat glucose electrochemical sensor that can be applied to continuous monitoring of glucose in human sweat. [0004] Technical solution: The preparation method of a flexible wearable sweat glucose ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30
CPCG01N27/26G01N27/308G01N27/301
Inventor 苏彤夏有缘张声浩舒韵
Owner YANGZHOU UNIV
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