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Delivery device for biocompatible droplets, manufacturing method and delivery method thereof

A technology of biocompatibility and delivery devices, which is applied in the field of delivery devices for biocompatible droplets, can solve the problems of no biocompatible droplet transportation reports, processing technology limitations, etc.

Pending Publication Date: 2022-07-01
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ratchet arrays fabricated on silicon wafers can achieve droplet transport, they are still limited by the inherent processing technology and no biocompatible droplet transport has been reported.

Method used

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  • Delivery device for biocompatible droplets, manufacturing method and delivery method thereof
  • Delivery device for biocompatible droplets, manufacturing method and delivery method thereof
  • Delivery device for biocompatible droplets, manufacturing method and delivery method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] like figure 1 As shown, the conveying device for biocompatible droplets described in this embodiment includes a base film 1 and a vibrating table, the base film 1 is arranged on the vibrating table, and the vibrating table applies vertical vibration to the base film 1 , so that the droplets located on the base film 1 vibrate periodically in the vertical direction and undergo periodic wetting and dewetting processes. The base film 1 is provided with several arcs 2, and several of the The arcs 2 are distributed in a linear array, forming an anisotropic ratchet array, so that the droplets on the ratchet array are asymmetrically subjected to resistance in all directions; the grooves of the arc 2 are filled with lubricating oil.

[0056]The radius of the circular arc 2 is 2 mm, the depth is 190 μm, and the distance between two adjacent circular arcs 2 is 160 μm.

[0057] The base film 1 adopts polydimethylsiloxane film; polydimethylsiloxane (PDMS) film is widely used in the...

Embodiment 2

[0068] A method for preparing a delivery device for biocompatible droplets, for preparing the delivery device for biocompatible droplets in Example 1, includes the following steps:

[0069] Preparation of S1 base film

[0070] 1.1 Mix the crosslinking agent and the prepolymer in a ratio of 1:12 to obtain a mixture;

[0071] 1.2 Degassing for 10min;

[0072] 1.3 The mixture is deposited on a glass slide placed on a spin coater and then spin-coated; the spin-coater rotates at 200-1000rpm, and the spin-coating time is 0-10min;

[0073] 1.4 Curing on the heating plate at 65°C for 2 hours to form a flat and uniform PDMS film with a thickness of 500 μm;

[0074] 1.5 Cut the PDMS film into several pieces of different sizes for arc processing;

[0075] S2 arc machining

[0076] 2.1 Ultrasonic cleaning of PDMS film with deionized water;

[0077] 2.2 Perform femtosecond laser direct writing on the PDMS film, and the surface of the film forms an arc with a linear array distribution;...

Embodiment 3

[0099] The delivery method of droplets, using the delivery device for biocompatible droplets in Example 1 to deliver droplets;

[0100] S1 drops the droplets into the ratchet array on the PDMS film, so that the droplets are anisotropically resisted in all directions on the PDMS film;

[0101] S2 applies a sinusoidal signal to the vibrating table through the signal generator, so that the vibrating table drives the PDMS film to vibrate vertically, so that the droplet is subjected to an isotropic driving force; the resultant force of the anisotropic resistance and the isotropic driving force is not equal to zero , so that the droplet is subjected to a force in the direction of the resultant force, so that it moves in the direction of the resultant force;

[0102] By adjusting the sinusoidal signal applied by the signal generator to the vibrating table, S3 can drive the frequency and amplitude of the vibration of the PDMS film by the vibrating table, and control the conveying spee...

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Abstract

The invention provides a conveying device for biocompatible liquid drops, which comprises a base membrane and a vibration table, the base membrane is arranged on the vibration table, the vibration table applies vertical vibration to the base membrane, so that the liquid drops on the base membrane periodically vibrate in the vertical direction and undergo periodic wetting and dewetting processes, a plurality of arcs are arranged on the base membrane, and the arcs are arranged on the base membrane. The plurality of arcs are distributed in a linear array to form an anisotropic ratchet wheel array, so that the liquid drops on the ratchet wheel array are asymmetrical due to resistance in each direction; the arc-shaped groove is filled with lubricating oil; the beneficial effects of the invention are that the base film is provided with a plurality of arcs in linear array distribution to form an anisotropic ratchet array, so that the resistance of liquid drops in all directions is asymmetric; the vibration table enables the liquid drops to vertically vibrate, applies isotropic driving force, continuously performs wetting and de-wetting states, and continuously moves in the direction of resultant force due to the fact that the sum of applied acting force is not equal to zero under switching of different states, so that transportation of the liquid drops is achieved.

Description

technical field [0001] The present invention relates to the technical field of droplet delivery, and in particular, to a delivery device, a manufacturing method and a delivery method for biocompatible droplets. Background technique [0002] Intelligent transport of droplets across interfaces plays an important role in numerous applications such as biomedical detection, chemical microreactions, and droplet microfluidics. Previous droplet delivery strategies can be divided into two categories: passive control without external energy input and active mode with external energy input. [0003] Passive strategies include single-surface chemical gradients and terrain slopes, however, these strategies have serious inherent limitations, such as short transmission distances, slow transmission speeds, and limited capacity ranges, which greatly hinder their practical applications. [0004] To achieve highly controllable on-demand transport of droplets, active strategies with external e...

Claims

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Application Information

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IPC IPC(8): B01J4/00B01L3/00
CPCB01J4/00B01L3/50273
Inventor 苏亚辉赵坤王芝云
Owner ANHUI UNIVERSITY
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