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Surface chemical modification method of PET (Polyethylene Terephthalate) flow blocking film, surface chemical modified PET flow blocking film and left auricle plugging device

A surface chemistry, blocking membrane technology, applied in the field of medical devices, can solve the problems of easy puncture of the heart, stuck on the edge of the sheath wall, poor fatigue strength, etc., to improve safe use efficiency, reduce blood vessel damage, and resist Excellent fatigue performance

Pending Publication Date: 2022-07-08
SHENZHEN KYD BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the anchoring thorns piercing the left atrium are repeatedly positioned, and when the occluder is recovered, it will be stuck on the edge of the sheath wall, making the occluder unable to be recovered, and repeated positioning
Moreover, the fixed plate of this hybrid left atrial appendage occluder usually deforms greatly to reverse the direction of the anchoring spines, causing the tension and deformation of the fixed plate to reach the limit value of the material
This device has poor fatigue strength in permanent implantation, and is prone to breakage, puncturing other tissues such as the heart, and endangering life
[0013] In addition, CN104352261A discloses a left atrial appendage occluder with an improved structure. The connecting plate provides support for the anchoring plate to form a rigid structure, so that the deformation is large and the processing is difficult. In addition, the planar structure of the anchoring plate is stable during the opening and recovery process. If it is larger than the diameter of the anchoring disc, it is easy to puncture other tissues such as the heart and endanger life. The schematic diagram of its opening is as follows Figure 11 shown

Method used

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  • Surface chemical modification method of PET (Polyethylene Terephthalate) flow blocking film, surface chemical modified PET flow blocking film and left auricle plugging device
  • Surface chemical modification method of PET (Polyethylene Terephthalate) flow blocking film, surface chemical modified PET flow blocking film and left auricle plugging device
  • Surface chemical modification method of PET (Polyethylene Terephthalate) flow blocking film, surface chemical modified PET flow blocking film and left auricle plugging device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] like figure 1 A left atrial appendage occluder, comprising a blocking disc 106 and an anchoring disc 101 connected with the blocking disc,

[0059] The plugging disc has a net-like structure with a flow blocking film 108 arranged inside. The distal end of the plugging disc is fixed with a tubular member 109, and the other end of the plugging disc is connected to the anchoring disc through the tubular member. The proximal end of the disc is fixed with a plug 110 and is provided with a structure for connecting with the delivery device;

[0060] The other end of the tubular member relative to the fixed blocking disk is provided with a plurality of support rods 102, the support rods are issued from a direction relative to the blocking disk, and the proximal end 102b of the support rod spans the center of the tubular member to the opposite side. The support rods are arranged in a cross radial pattern to form the anchoring disc 101. The angle α between the proximal end 102b...

Embodiment 2

[0062] like figure 1 A left atrial appendage occluder, comprising a blocking disc 106 and an anchoring disc 101 connected with the blocking disc,

[0063] The plugging disc has a net-like structure with a flow blocking film 108 arranged inside. The distal end of the plugging disc is fixed with a tubular member 109, and the other end of the plugging disc is connected to the anchoring disc through the tubular member. The proximal end of the disc is fixed with a plug 110 and is provided with a structure for connecting with the delivery device;

[0064] The other end of the tubular member relative to the fixed blocking disk is provided with a plurality of support rods 102, the support rods are issued from a direction relative to the blocking disk, and the proximal end 102b of the support rod spans the center of the tubular member to the opposite side. The support rods are arranged in a cross radial pattern to form the anchoring disc 101. The angle α between the proximal end 102b...

Embodiment 3

[0067] like figure 2 A left atrial appendage occluder, comprising a blocking disc 106 and an anchoring disc 101 connected with the blocking disc,

[0068] The plugging disc has a net-like structure with a flow blocking film 108 arranged inside. The distal end of the plugging disc is fixed with a tubular member 109, and the other end of the plugging disc is connected to the anchoring disc through the tubular member. The proximal end of the disc is fixed with a plug 110 and is provided with a structure for connecting with the delivery device;

[0069] The other end of the tubular member relative to the fixed blocking disk is provided with a plurality of support rods 102, the support rods are issued from a direction relative to the blocking disk, and the proximal end 102b of the support rod spans the center of the tubular member to the opposite side. The support rods are arranged in a cross radial pattern to form the anchoring disc 101. The angle α between the proximal end 102b...

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Abstract

The invention provides a surface chemical modification method of a PET (Polyethylene Terephthalate) flow choking membrane, the flow choking membrane prepared by the method and a left atrial appendage occluder comprising the flow choking membrane, and the method comprises the step of grafting molecules with sodium sulfonate groups on one side to the surface of the PET flow choking membrane by utilizing a chemical reaction of replacing ester groups into amide groups. And the surface of the flow choking film is electronegativity. According to the prepared modified flow blocking membrane, the biocompatibility is improved, endothelialization is rapid, and thrombus formation is reduced. The left auricle plugging device is good in effect of blocking thrombus in a left auricle from flowing out, capable of being repeatedly positioned, stable in fixation and good in fatigue resistance.

Description

[0001] This application is a divisional application of the original Chinese invention patent application CN201680072308.4. The application date of the original application is December 26, 2016, and the name of the invention-creation of the original application is "left atrial appendage occluder". [0002] The original application is an invention patent application entered into China's national phase based on the international application PCT / CN2016 / 112062 with an application date of December 26, 2016 under the Patent Cooperation Treaty. [0003] The international application, the original application and the present application all claim the priority of the following patent applications: [0004] A Chinese invention patent application entitled "Left atrial appendage occluder" with application number CN201511003714.9, filed on December 29, 2015; and [0005] The Chinese invention patent application named "Left atrial appendage occluder" and the application number is CN20161011916...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/12
CPCA61B17/12122A61B17/12031A61B17/12177A61B2017/00796A61B17/0057A61B17/12172A61B2017/00575A61B2017/00579A61B2017/00592A61B2017/00597A61B2017/00615A61B2017/00938A61L31/06A61L31/14A61L2400/18C08L67/02A61B17/12A61F2/00A61B17/12145
Inventor 陈奕龙黄伟
Owner SHENZHEN KYD BIOMEDICAL TECH CO LTD
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