Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of vitamin D receptor stimulant in preparation of medicine for preventing and/or treating inflammatory bone loss

A receptor agonist, bone loss technology, applied in drug combinations, bone diseases, anti-tumor drugs, etc., can solve problems such as neutropenia, severe diarrhea, esophageal cancer, and renal failure

Pending Publication Date: 2022-07-08
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] All of the above drugs have adverse reactions of varying degrees. For example, bisphosphonates may cause serious adverse reactions such as osteonecrosis of the jaw, esophageal cancer, and renal failure; common adverse reactions of denosumab include back pain, limb pain, and musculoskeletal pain. etc.; common adverse reactions of certolizumab include neutropenia, severe diarrhea

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of vitamin D receptor stimulant in preparation of medicine for preventing and/or treating inflammatory bone loss
  • Application of vitamin D receptor stimulant in preparation of medicine for preventing and/or treating inflammatory bone loss
  • Application of vitamin D receptor stimulant in preparation of medicine for preventing and/or treating inflammatory bone loss

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] 1. Construction of an animal model of inflammatory bone loss caused by inactivation of Staphylococcus aureus and drug administration

[0064] Co-60 irradiation-inactivated Staphylococcus aureus was suspended in PBS to make 5 × 10 8 The bacterial solution of CFU / mL was stored at -20°C, thawed and mixed well before use. Each mouse in the inflammation group and the calcitriol treatment group was pressed 4 × 10 9 The dose of CFU / kg was injected into the bacterial solution (the blank control group was injected with the same amount of PBS each time); calcitriol was dissolved in DMSO to prepare a stock solution with a concentration of 10 μg / mL, and 10 μL of the stock solution was added to 490 μL of PBS to prepare 200ng / mL working solution, each mouse in the calcitriol treatment group was injected with 400ng / kg of calcitriol working solution each time (the blank control group and the inflammation group were injected with the same amount of PBS each time).

[0065] Fourteen 12-...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicines, and discloses application of a vitamin D receptor stimulant in preparation of a medicine for preventing and / or treating inflammatory bone loss. The invention discloses the application of the vitamin D receptor agonist or the pharmaceutically acceptable salt thereof in preparation of the medicine for preventing and / or treating inflammatory bone loss for the first time. The vitamin D receptor agonist or the pharmaceutically acceptable salt thereof can significantly reduce bone trabecular mode factors of mice with inflammatory bone loss, significantly increase bone mineral density, bone tissue volume / total tissue volume and bone trabecular number of the mice with inflammatory bone loss, and also can improve bone trabecular thickness of the mice with inflammatory bone loss and reduce bone trabecular gaps, so that the vitamin D receptor agonist or the pharmaceutically acceptable salt thereof can be used for preparing medicines for treating inflammatory bone loss. Vitamin D receptor agonists can treat and / or prevent inflammatory bone loss.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of a vitamin D receptor agonist in the preparation of a medicine for preventing and / or treating inflammatory bone loss. Background technique [0002] Inflammatory bone loss is one of the common complications of chronic inflammatory diseases. In the past, doctors and patients have been troubled by the limitations of its understanding and treatment. Under physiological conditions, the maintenance of bone mass depends on the dynamic balance between bone resorption by osteoclasts and bone formation by osteoblasts, both of which are involved in the process of bone remodeling. Stimulated by chronic inflammation, the homeostasis between osteoclasts and osteoblasts is altered, leading to disorders of bone metabolism. Epidemiological studies suggest that inflammatory diseases can occur throughout the body, including the musculoskeletal system (eg, rheumatoid arthritis), ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/00A61K31/593A61K31/592A61P19/08A61P19/02A61P37/02A61P19/06A61P1/00A61P35/00A61P19/00A61P31/00
CPCA61K45/00A61K31/593A61K31/592A61P19/08A61P19/02A61P37/02A61P19/06A61P1/00A61P35/00A61P19/00A61P31/00Y02A50/30
Inventor 张先荣余斌程楚斌贺瑞怡
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com