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Compositions and methods with probiotics and N-3 fatty acids for preventing or treating mastitis

A technique for mastitis, fatty acid, applied in the field of subclinical mastitis, treatment or prevention of mastitis, mastitis such as subclinical mastitis

Pending Publication Date: 2022-07-15
SOC DES PROD NESTLE SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are several challenges to the widespread use of antibiotics, including ineffectiveness due to antibiotic resistance, development of multi-antibiotic resistant bacterial strains, biofilm formation, vaginal candidiasis, and antibiotic-associated diarrhea
[0010] Furthermore, it has been shown that there is insufficient evidence to support the effectiveness of antibiotic therapy in the treatment of lactating mastitis (Jahanfar, S. et al., 2013, Cochrane Database Systematic Review 28: CD005458)

Method used

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  • Compositions and methods with probiotics and N-3 fatty acids for preventing or treating mastitis
  • Compositions and methods with probiotics and N-3 fatty acids for preventing or treating mastitis
  • Compositions and methods with probiotics and N-3 fatty acids for preventing or treating mastitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0258] method

[0259] In the framework of a multicenter European observational study (the Atlas study of human milk nutrients) characterizing the composition of human milk (HM) in the first four months of lactation, we based on the sodium / potassium (Na / K) ratio in human milk A presentation was made to understand whether there are differences in the composition of human milk between lactating women with subclinical mastitis (SCM) and women without SCM.

[0260] research proposal

[0261] The ATLAS study was conducted in seven European countries (France, Italy, Norway, Portugal, Romania, Spain and Sweden) as longitudinal observational cohorts at six postpartum time points (0-3 days, 17±3 days, 30±3 days) 3 days, 60±5 days, 90±5 days and 120±5 days) human milk and various maternal and infant parameters were collected. The study was approved by the institutional and local ethics committees of each center. Participants provided written informed consent to participate in thi...

Embodiment 2

[0284] method

[0285] research group

[0286] The study used data from "ATLAS", a longitudinal observational study conducted in seven European countries between December 2012 and January 2016. The study was approved by each center's institutional and local ethics committees and is registered with ClincalTrials.gov with the identifier NCT01894893. Maternal and infant demographic data, anthropometric data, and medical history were collected by trained and certified research nurses and assistants.

[0287] Human milk was collected from 305 women in 7 European countries. Of these, 185 provided information on dietary intake. Eight women were further excluded due to missing information, resulting in a final sample size of 177 women. Written informed consent was obtained from all women in their respective local languages.

[0288] SCM analysis

[0289] Throughout the study, milk samples were obtained from the ipsilateral breast at 11:00 am ± 2:00 hours using an electric ...

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PUM

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Abstract

The present invention provides a mixture or nutritional composition for use in the treatment or prevention of mastitis in an individual, preferably a pregnant woman or a lactating woman, comprising the probiotic Lactobacillus fermentum CECT-5716 and an n-3 fatty acid selected from the group consisting of docosahexaenoic acid (DHA) and 18: 3n-3 octadecatrienoic acid (alpha-linolenic acid), and optionally an additional nutrient or mineral selected from iron, manganese and magnesium or a combination of two or more thereof.

Description

technical field [0001] The present invention relates to compositions for the treatment or prevention of mastitis, eg, subclinical mastitis, in an individual. In particular, the present invention relates to fatty acids such as docosahexaenoic acid (DHA) and 18:3n-3 octadecatrienoic acid (α-linolenic acid) with specific probiotics L. fermentum CECT Use of -5716 in the treatment or prevention of mastitis, especially subclinical mastitis. Background technique [0002] WHO recommends that infants should be exclusively breastfed for the first six months of life for optimal growth, development and health, and continue breastfeeding until age 2. According to WHO, "exclusive breastfeeding" means that the infant receives only breast milk (no other liquids or solids, not even water, except for oral rehydration solutions or drops / syrups of vitamins, minerals or drugs). WHO also recommends early initiation of breastfeeding, as this may be critical for neonatal survival and long-term es...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K33/26A61K33/06A61K33/32A61K31/355A61K45/06
CPCA61K35/747A61K33/26A61K33/06A61K33/32A61K31/355A61K45/06A61K31/202A61K31/685A61K2300/00A61P15/14A61K38/38A61K38/385A61K38/40A61K2035/115
Inventor T·M·塞缪尔
Owner SOC DES PROD NESTLE SA
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