Supercharge Your Innovation With Domain-Expert AI Agents!

High-strength natural polymer hydrogel as well as preparation method and application thereof

A natural polymer, hydrogel technology, applied in prosthesis, bandages, medical science and other directions, can solve the problem of human carcinogenic risk and other issues

Pending Publication Date: 2022-07-19
TIANJIN UNIV
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some studies have also shown that soaking polyvinyl alcohol (PVA) or polyacrylamide (PAAm) gels in tannic acid (TA) solutions can improve their mechanical properties, however, according to the report of the World Health Organization, high concentrations of tannic acid (TA) Nitric acid (TA) may pose a carcinogenic risk to humans

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-strength natural polymer hydrogel as well as preparation method and application thereof
  • High-strength natural polymer hydrogel as well as preparation method and application thereof
  • High-strength natural polymer hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 0.2g of GelMA into a 10mL centrifuge tube with a tray balance, then add 1mL of deionized water to dissolve it, and finally add 4uL of 1173 to the centrifuge tube and mix it well. After sealing, it was placed in a UV cross-linking apparatus for UV irradiation for 40 min. GelMA-TP hydrogels were obtained by soaking the prepared gels in 20% TP solution at 37 °C for 48 hours.

Embodiment 2

[0027] Weigh 0.2g of GelMA into a 10mL centrifuge tube with a tray balance, then add 1mL of deionized water to dissolve it, and finally add 4uL of 1173 to the centrifuge tube and mix it well. After sealing, it was placed in a UV cross-linking apparatus for UV irradiation for 40 min. The prepared gel was soaked in 25% TP solution at 38℃ for 5 hours to obtain GelMA-TP hydrogel.

Embodiment 3

[0029] Weigh 0.3 g of AG into a 100 mL beaker with a tray balance, then add 10 mL of deionized water to heat it to 90 °C to dissolve it, and put it into a mold while it is still hot to make a sheet-like gel. The prepared gel was soaked in 20% TP solution at 37 °C for 6 hours to obtain AG-TP hydrogel.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Tensile strengthaaaaaaaaaa
Young's modulusaaaaaaaaaa
Elongation at breakaaaaaaaaaa
Login to View More

Abstract

The invention provides high-strength natural polymer hydrogel and a preparation method and application thereof.The high-strength natural polymer hydrogel is obtained after hydrogel with the strength to be enhanced is soaked in a tea polyphenol (TP) solution for 5-50 h at the temperature of 35-40 DEG C, and the mass percentage of the tea polyphenol (TP) solution is 15-25%. Compared with the original hydrogel, the high-strength natural polymer hydrogel (GelMA-TP) taking gelatin as the substrate has the advantages that the tensile / compressive strength, Young modulus, elongation at break and fracture toughness of representative natural polymers (NP) treated by tea polyphenol (TP) are obviously improved due to hydrogen bond interaction between the tea polyphenol (TP) and natural polymer (NP) chains; in-vivo biological experiments are carried out in a rat full-thickness skin injury model, and the high-strength natural polymer hydrogel (GelMA-TP) taking gelatin as a substrate can better promote wound healing.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a high-strength natural polymer hydrogel and a preparation method and application thereof. Background technique [0002] Natural polymer (NP) hydrogels have good biocompatibility and biodegradability, and are an important class of biomaterials in the field of biomedicine. However, traditional natural polymer (NP) hydrogels severely limit their application in tissue engineering due to their weak mechanical properties and single function. In the past decade, high-strength hydrogels have undergone tremendous advances in design principles; however, previous studies have focused on synthetic polymer hydrogels. Although a great deal of effort has been devoted to improving the mechanical strength of natural polymer hydrogels, their strategies mainly rely on the introduction of synthetic polymers, which inevitably affects their biodegradability and biocompatibility. [000...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L26/00A61L27/20A61L27/22A61L27/52A61L27/50C08J3/075C08L89/00C08L5/12C08L5/04
CPCA61L26/0038A61L26/0023A61L26/008A61L26/0061A61L27/20A61L27/222A61L27/52A61L27/50C08J3/075C08J2389/00C08J2305/12C08J2305/04C08L89/00C08L5/04C08L5/12
Inventor 刘文广崔春燕
Owner TIANJIN UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com