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Extraction method of solanum nigrum fruit extract

An extraction method and technology of Solanum nigrum fruit, which can be applied in medical formula, drug combination, plant raw materials, etc., can solve the problems of lack of research and inability to clarify the hypoglycemic mechanism, achieve simple process, improve the symptoms of high blood sugar, and enhance expression volume effect

Pending Publication Date: 2022-07-22
SHAANXI HEALTHFUL BIOLOGICAL ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is a lack of research on the hypoglycemic effect of Solanum nigrum, and it is impossible to clarify its hypoglycemic mechanism, and it is impossible to extract the best extract to target patients with hyperglycemia

Method used

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  • Extraction method of solanum nigrum fruit extract
  • Extraction method of solanum nigrum fruit extract
  • Extraction method of solanum nigrum fruit extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1: Extraction of nightshade fruit extract

[0076] The implementation of this example is as follows:

[0077] A. Solanum bean raw material pretreatment

[0078] The fresh nightshade fruit is cleaned, air-dried naturally to reach its water content of 9.8% based on the weight of the nightshade fruit, pulverized by a pulverizing device, sieved by a screening device, and the powdered nightshade fruit with a particle size of less than 60 meshes is collected;

[0079] B. to soak

[0080] At room temperature, according to the ratio of the Solanum nirvana fruit powder in grams and the distilled water in milliliters to be 1:1.5, add the Solanum nirvana fruit powder obtained in step A to the distilled water and soak for 3.2 hours to obtain the Solanum nirvana fruit infusion;

[0081] C. leaching

[0082] The solanum nigrum fruit powder soaked product obtained in step B is 1:50 in volume of the leaching solution of the hydrochloric acid mineral acid aqueous solution, us...

Embodiment 2

[0085] Example 2: Extraction of nightshade fruit extract

[0086] The implementation of this example is as follows:

[0087] A. Solanum bean raw material pretreatment

[0088] The fresh nightshade fruit is cleaned, air-dried naturally to reach its water content of 9.9% by weight of the nightshade fruit, pulverized with a crushing equipment, sieved with a sieving equipment, and collected the nightshade fruit powder with a particle size of less than 60 meshes;

[0089] B. to soak

[0090] At room temperature, according to the ratio of the Solanum nigrum fruit powder in grams and the distilled water in milliliters to be 1:2.0, the Solanum nirvana fruit powder obtained in step A was added to the distilled water and soaked for 3.6 hours to obtain a solanum nigrum fruit powder infusion;

[0091] C. leaching

[0092]The Solanum nigrum fruit powder soaked product obtained in step B is 1:40 according to the volume of the leaching solution of the hydrochloric acid mineral acid aqueou...

Embodiment 3

[0095] Example 3: Extraction of nightshade fruit extract

[0096] The implementation of this example is as follows:

[0097] A. Solanum bean raw material pretreatment

[0098] The fresh nightshade fruit is cleaned, air-dried naturally to reach its water content of 9.4% by weight of the nightshade fruit, pulverized by pulverizing equipment, sieved by a screening equipment, and collected the nightshade fruit powder with a particle size of less than 60 meshes;

[0099] B. to soak

[0100] At room temperature, according to the ratio of the Solanum nirvana fruit powder in grams and the distilled water in milliliters to be 1:1.0, add the Solanum nirvana fruit powder obtained in step A to the distilled water and soak for 2.0h to obtain the infusion of Solanum nigrum fruit powder;

[0101] C. leaching

[0102] The solanaceous fruit powder soaked product obtained in step B, according to the volume of it and the leaching solution of the inorganic alkali aqueous solution of sodium hyd...

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Abstract

The invention relates to an extraction method of a solanum nigrum fruit extract for regulating type II diabetes insulin pathway and sensitizing insulin. The extraction method comprises the following steps: pretreating a solanum nigrum fruit raw material, soaking, extracting, concentrating, drying and the like. The solanum nigrum fruit extract obtained by adopting the extraction method disclosed by the invention can obviously improve the symptom of high blood sugar of diabetic rats, can well recover to a normal level, and has an obvious inhibition effect.

Description

【Technical field】 [0001] The invention belongs to the technical field of natural product extraction. More specifically, the present invention relates to a method for extracting Solanum nigrum fruit extract for regulating the insulin pathway of type II diabetes and insulin sensitization. 【Background technique】 [0002] Type 2 diabetes (Diabetes mellitus type 2, T2DM) is a chronic metabolic disease, defined as insulin secretion defect, resulting in abnormal glucose metabolism and related metabolic disorders. At present, more than 90% of diabetic patients are type Ⅱ diabetes, and diabetes gradually tends to be younger. Studies have found that type 2 diabetes is mainly characterized by insulin resistance, which is mostly related to abnormal insulin signaling pathways and insulin desensitization. [0003] Solanum nigrum Linn, also known as bitter sunflower, day eggplant, wild eggplant, etc., is an annual herb of the nightshade family Solanaceae, which is distributed all over my...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P3/10A61P5/50A61K131/00
CPCA61K36/81A61P3/10A61P5/50A61K2236/33A61K2236/333A61K2236/331A61K2236/39A61K2236/51
Inventor 郭建琦刘昌财杨璐牛永洁孟永宏
Owner SHAANXI HEALTHFUL BIOLOGICAL ENG
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