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Fluorescent magnetic resonance bimodal imaging nanoprobe for targeting tumor site

A dual-modal imaging and nano-probe technology is applied in the field of nanomaterials to achieve the effects of increasing the metabolic burden of the body, good biocompatibility, and simple synthesis process operation.

Pending Publication Date: 2022-07-22
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI +1
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no reliable solution for using AIE dyes to prepare fluorescent magnetic resonance dual-modality imaging probes

Method used

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  • Fluorescent magnetic resonance bimodal imaging nanoprobe for targeting tumor site
  • Fluorescent magnetic resonance bimodal imaging nanoprobe for targeting tumor site
  • Fluorescent magnetic resonance bimodal imaging nanoprobe for targeting tumor site

Examples

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Embodiment 1

[0053] This embodiment provides a fluorescent magnetic resonance dual-modality imaging nanoprobe targeting a tumor site, which is prepared by the following method:

[0054] 1) Preparation of Fe 3 O 4 Nanoparticles:

[0055] 1-1) Take 2.5mmol of iron triacetylacetonate Fe(acac) 3 , the 1,2-hexadecanediol of 15mmol, the oleylamine of 8mmol, the oleic acid of 8mmol and the dibenzyl ether of 25mL were successively added in the there-necked flask of 250mL;

[0056] 1-2) Stir under nitrogen protection, gradually heat up to 200°C, and conduct constant temperature reaction at this temperature for 2.5h;

[0057] 1-3) Then heat to 300°C for reflux and keep for 1h;

[0058] 1-4) remove the heating device and the insulation device, and cool the reaction system to room temperature;

[0059] 1-5) after the reaction is completed, add ethanol to the product obtained, ultrasonic dispersion is then centrifuged for 6min at a rotating speed of 6000rad / min, discard the upper layer liquid to r...

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Abstract

The invention discloses a fluorescent magnetic resonance bimodal imaging nanoprobe targeting a tumor site. The fluorescent magnetic resonance bimodal imaging nanoprobe is prepared by the following method: 1) preparing Fe3O4 nanoparticles; (2) preparing NPAPF-Fe3O4 composite nanoparticles; and (3) modifying PEG (Polyethylene Glycol) on the surfaces of the composite nanoparticles. According to the invention, the characteristic of aggregation fluorescence enhancement of an AIE dye NPAPF is utilized, a simple preparation process is adopted, Fe3O4 nanoparticles for a magnetic resonance imaging probe are loaded in the process of preparing NPAPF nanoparticles, and NPAPF-Fe3O4 composite nanoparticles are formed; the fluorescent magnetic resonance bimodal imaging nano-probe capable of targeting a tumor part is obtained by adopting a magnetic resonance imaging technology and further adopting PEG (Polyethylene Glycol) for surface modification, and has good biocompatibility while having a magnetic targeting function and an MR bimodal imaging function, the synthesis process is simple to operate, and no redundant carrier is used for increasing the metabolic burden of an organism.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a fluorescent magnetic resonance dual-modality imaging nanoprobe targeting tumor sites. Background technique [0002] Sensitive and accurate imaging modalities can advance precise medical diagnosis and treatment. Multimodal imaging probes have become powerful tools to improve the sensitivity and accuracy of disease detection, and are of great significance in disease diagnosis and treatment. By combining multiple imaging modalities, the defects of each imaging method can be compensated, and non-invasive imaging with stronger penetration and higher resolution, as well as more accurate diagnosis and higher sensitivity can be obtained. Among them, fluorescence / magnetic resonance dual-modality imaging has received much attention in the past decades. [0003] Magnetic resonance imaging is one of the most powerful diagnostic tools in medicine at present, and its contrast agent i...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/12A61K49/18
CPCA61K49/0002A61K49/0021A61K49/0054A61K49/0093A61K49/126A61K49/186
Inventor 南雪燕何良王彤刘志周白鹏利
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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