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Functionalized bimodal imaging nanoprobe, preparation method thereof and application of functionalized bimodal imaging nanoprobe in aortic aneurysm diagnosis

A dual-mode imaging and nanoprobe technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as lack of reliable solutions, achieve good biocompatibility, and simple synthetic process operation

Inactive Publication Date: 2020-07-31
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But now there is no reliable solution

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  • Functionalized bimodal imaging nanoprobe, preparation method thereof and application of functionalized bimodal imaging nanoprobe in aortic aneurysm diagnosis
  • Functionalized bimodal imaging nanoprobe, preparation method thereof and application of functionalized bimodal imaging nanoprobe in aortic aneurysm diagnosis

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Embodiment 1

[0030] This embodiment provides a functionalized dual-mode imaging nanoprobe, which is polyethylene glycol-surface-modified ferric oxide@ceria / zirconia composite nanoparticles, namely PEG-Fe 3 o 4 @CeO 2 / ZrO 2 composite nanoparticles. where Fe 3 o 4 As a contrast agent for magnetic resonance imaging (MR), it can scan in any selected direction, with full three-dimensional function, excellent soft tissue contrast and high spatial resolution. Ce / Zr has high X-ray absorption. Using this nanoparticle as a contrast agent for CT imaging, through X-ray tomography, the electronic photon detector receives and converts the signal into a digital input to the electronic computer. After being converted into an image by the computer, it is A rapid, sensitive and high-resolution detection method. PEG-Fe prepared by combining these functional materials 3 o 4 @CeO 2 / ZrO 2 Composite nanoprobes can realize MR and CT dual-modal imaging, and can combine the advantages of these two imagi...

Embodiment 2

[0032] This embodiment provides the preparation method of the functionalized dual-mode imaging nanoprobe in Example 1, refer to figure 1 , which includes the following steps:

[0033] 1) Preparation of hollow porous structure CeO 2 / ZrO 2 Nanoparticles:

[0034] 1 mL of Ce(NO 3 ) 3 (0.5M) solution, add 30mL of ethylene glycol to stir, stir well, seal the mixture and heat at 180°C for 16 hours; when the reactant is cooled to room temperature, add 0.5mL of ZrOCl 2 (0.5M) solution, mix well. The mixture was then sealed and heated at 180 °C for another 3 hours; CeO with a hollow porous structure was finally obtained 2 / ZrO 2 Nanoparticles were washed by centrifugation with ethanol at 8000rpm for 15min, repeated three times.

[0035] 2) In the hollow porous structure CeO 2 / ZrO 2 In situ synthesis of Fe on nanoparticles 3 o 4 , get Fe 3 o 4 @CeO 2 / ZrO 2 Composite nanoparticles:

[0036] With the CeO that described step 1) makes 2 / ZrO 2 The nanoparticles were dr...

Embodiment 3

[0041] (1) To 40mL of FeCl 2 (300mg / mL) solution was added 0.5g dry CeO 2 / ZrO 2 nanoparticles;

[0042] (2) Nitrogen protection, soak for 30 minutes;

[0043] (3) Filter out excess FeCl 2 solution, adding NaNO 2 The solution was continuously stirred and reacted for 1h, and the stirring speed was 160r / min;

[0044] (4) Quickly add ammonium hydroxide aqueous solution (28wt%) into the reaction solution, and increase the stirring speed to 600r / min, and react for 2h;

[0045](5) Stop the reaction, remove the supernatant by centrifuging at 6000rpm for 10min to obtain Fe 3 o 4 @CeO 2 / ZrO 2 composite nanoparticles.

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Abstract

The invention discloses a functionalized bimodal imaging nano-probe, a preparation method thereof and application of the functionalized bimodal imaging nano-probe in aortic aneurysm diagnosis. The probe is a ferroferric oxide@cerium dioxide / zirconium dioxide composite nano-particle subjected to polyethylene glycol surface modification. The method comprises the followings steps: designing and synthesizing the CeO2 / ZrO2 nano-particle with a hollow porous structure, ingeniously utilizing a unique hollow porous structure, controlling reaction conditions, synthesizing Fe3O4 in situ inside and on the surface of the nano-particle, and further carrying out surface modification by adopting PEG so as to finally obtain the PEG-Fe3O4@CeO2 / ZrO2 composite nano-particle. The composite nanoparticle has the MR and CT bimodal imaging functions and also has good biocompatibility, the synthesis process is simple to operate, and no redundant carrier is used for increasing the metabolic burden of an organism; and the composite nano-particle can be used as a functional bimodal imaging nanoprobe and applied to aortic aneurysm diagnosis.

Description

technical field [0001] The invention relates to the field of biological materials, in particular to a functionalized dual-mode imaging nanoprobe, its preparation method and its application in aortic aneurysm diagnosis. Background technique [0002] At present in our country, the incidence of aortic aneurysm is also rising, more common in middle-aged and elderly people, and the incidence rate of people over 65 years old is as high as 8.8%. Aneurysm rupture occurs in many patients without any symptoms, and once it ruptures and bleeds, the case fatality rate can reach more than 80%. Aortic aneurysms can occur anywhere in the aorta, but there are two main types, thoracic aortic aneurysms that occur in the chest, and abdominal aortic aneurysms that occur in the abdomen, which grow and expand into the vascular network and The surrounding tissue penetrates, erodes, and destroys. An abdominal aortic aneurysm may cause pain in the back, abdomen, legs, or groin and a pulsating sensa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/00A61K49/04A61K49/18B82Y5/00B82Y15/00
CPCA61K49/126A61K49/0002A61K49/04A61K49/186B82Y5/00B82Y15/00
Inventor 南雪燕白鹏利何良王彤
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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