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Dry chemical reagent tablet for high-density lipoprotein cholesterol and preparation method of dry chemical reagent tablet

A high-density lipoprotein and cholesterol technology, which is applied in material analysis by observing the effect on chemical indicators, analysis by chemical reaction of materials, color/spectral property measurement, etc., can solve the problem of insufficient sensitivity of hydrogen peroxide. , to increase stability, improve accuracy and precision, and reduce interference

Pending Publication Date: 2022-07-29
中科嘉睿(天津)医疗科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that when the HDL-C concentration is low, less hydrogen peroxide is produced, and the quantum dots are not sensitive enough to hydrogen peroxide at this time

Method used

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  • Dry chemical reagent tablet for high-density lipoprotein cholesterol and preparation method of dry chemical reagent tablet
  • Dry chemical reagent tablet for high-density lipoprotein cholesterol and preparation method of dry chemical reagent tablet
  • Dry chemical reagent tablet for high-density lipoprotein cholesterol and preparation method of dry chemical reagent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The prepared reaction reagent 1 was coated on a highly asymmetric polysulfone (BTS) membrane using a coating machine, and was vacuum dried at 30-50 °C for 2 h. Use the prepared reagents 2 and 3 to soak the polyethersulfone (PES) membrane and the blood filtration membrane for 5 minutes, respectively, and vacuum dry at 30-50°C for 2 hours. The highly asymmetric polysulfone (BTS) membrane, polyethersulfone (PES) membrane, blood filtration membrane and nylon membrane were cut into rectangular pieces of 8.3mm*4.4mm size using a microcomputer rapid cutter in turn, and assembled in sequence Put it into the card case, and put it in an opaque bottle containing a desiccant and store it away from light.

[0048] Reagent 1:

[0049] Phosphate buffer (pH=6.8) 100mM Hydroxypropylmethylcellulose 25g / L cholesterol esterase 35U / mL cholesterol oxidase 22U / mL peroxidase 800U / mL trehalose 0.1％ BSA 0.2％ Chromogen 0.25％ methanol...

Embodiment 2

[0056] The prepared reaction reagent 1 was coated on a highly asymmetric polysulfone (BTS) membrane using a coating machine, and was vacuum dried at 30-50 °C for 2 h. Use the prepared reagents 2 and 3 to soak the polyethersulfone (PES) membrane and the blood filtration membrane for 5 minutes, respectively, and vacuum dry at 30-50°C for 2 hours. The highly asymmetric polysulfone (BTS) membrane, polyethersulfone (PES) membrane, blood filtration membrane and nylon membrane were cut into rectangular pieces of 8.3mm*4.4mm size using a microcomputer rapid cutter in turn, and assembled in sequence Put it into the card case, and put it in an opaque bottle containing a desiccant and store it away from light.

[0057] Reagent 1:

[0058] Phosphate buffer (pH=6.8) 100mM Hydroxypropylmethylcellulose 25g / L cholesterol esterase 35U / mL cholesterol oxidase 22U / mL peroxidase 800U / mL trehalose 0.1％ BSA 0.2％ Chromogen 0.25％ methanol...

Embodiment 3

[0065] The prepared reaction reagent 1 was coated on a highly asymmetric polysulfone (BTS) membrane using a coating machine, and was vacuum dried at 30-50 °C for 2 h. Use the prepared reagents 2 and 3 to soak the polyethersulfone (PES) membrane and the blood filtration membrane for 5 minutes, respectively, and vacuum dry at 30-50°C for 2 hours. The highly asymmetric polysulfone (BTS) membrane, polyethersulfone (PES) membrane, blood filtration membrane and nylon membrane were cut into rectangular pieces of 8.3mm*4.4mm size using a microcomputer rapid cutter in turn, and assembled in sequence Put it into the card case, and put it in an opaque bottle containing a desiccant and store it away from light.

[0066] Reagent 1:

[0067] Phosphate buffer (pH=6.8) 100mM Hydroxypropylmethylcellulose 25g / L cholesterol esterase 25U / mL cholesterol oxidase 14U / mL peroxidase 500U / mL trehalose 0.1％ BSA 0.2％ Chromogen 0.25％ methanol...

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Abstract

The invention provides a high-density lipoprotein cholesterol dry chemical reagent tablet and a preparation method thereof. The high-density lipoprotein cholesterol dry chemical reagent tablet comprises a lower clamping shell, a multilayer film and an upper clamping shell, the lower clamping shell is mounted below the upper clamping shell; the high-density lipoprotein cholesterol dry chemical reagent piece comprises a lower clamping shell and an upper clamping shell, a test hole is formed in one side of the lower clamping shell, a multi-layer film groove used for containing a multi-layer film is formed in the other side of the lower clamping shell, the multi-layer film is arranged in the multi-layer film groove, and a sample adding hole is formed in the upper clamping shell. The stability, the uniformity and the color rendering degree of the reagent are improved, and the interference caused by bubbles generated by measurement at a sample adding end is reduced. Whole blood, serum and plasma can be used as specimens. The test accuracy and precision can be improved.

Description

technical field [0001] The invention and creation belong to the technical field of in vitro clinical diagnostic reagents, in particular to a high-density lipoprotein cholesterol dry chemical reagent tablet and a preparation method thereof. Background technique [0002] Lipoproteins in the blood are complexes of fat and apolipoprotein, which transport cholesterol. Lipoproteins come in four forms: chylomicrons, very low density lipoproteins (VLDL), low density lipoproteins (LDL), and high density lipoproteins (HDL). HDL receives cholesterol from various tissues including the arterial wall, and is transported into the liver by direct or indirect reverse transport, and is then removed from the blood. Therefore, HDL is involved in the removal of cholesterol accumulated in cells. High-density lipoprotein plays a physiological role in transporting cholesterol from extrahepatic tissue to the liver, thus preventing the deposition of free cholesterol on extrahepatic tissue cells. Ar...

Claims

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Application Information

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IPC IPC(8): G01N21/78G01N21/31
CPCG01N21/78G01N21/31
Inventor 白鹏利钱庆李超魏永红章强
Owner 中科嘉睿(天津)医疗科技发展有限公司
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