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Multifunctional composite scaffold as well as preparation method and application thereof

A composite stent and multi-functional technology, which can be used in drug combinations, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of high tumor recurrence rate, difficulty in effectively killing residual tumor cells, etc., and achieve the effect of reducing the recurrence rate.

Pending Publication Date: 2022-08-09
THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the present application provides a multifunctional composite scaffold and its preparation method and application, which are used to solve the technical problems that the existing technical means are difficult to effectively kill residual tumor cells and the tumor recurrence rate is high

Method used

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  • Multifunctional composite scaffold as well as preparation method and application thereof
  • Multifunctional composite scaffold as well as preparation method and application thereof
  • Multifunctional composite scaffold as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The present embodiment 1 provides a preparation method of a multifunctional composite scaffold, comprising the following steps:

[0079] Step 1. Preparation of degradable electrospinning membrane.

[0080] Step 1.1. Preparation of outer layer electrospinning solution:

[0081] Dissolve 600 mg of PLGA solution in 4 mL of hexafluoroisopropanol solution, place a magnetic stirring bar in the solution, and stir uniformly with magnetic stirring or other stirring methods to obtain an outer layer of electrospinning solution.

[0082] Step 1.2, prepare the inner layer electrospinning solution containing chemotherapeutic drugs:

[0083] Dissolve 400 mg of PVA and chemotherapeutic drug solution in 2 mL of water, and place a magnetic stirrer in the solution to stir evenly with magnetic stirring or other stirring methods to obtain an inner layer electrospinning solution.

[0084] Step 1.3, electrospinning:

[0085] The two syringes that absorb the inner layer of electrospinning s...

Embodiment 2

[0094] This Example 2 provides a preparation method of a multifunctional composite scaffold. The difference between the preparation method and Example 1 is that the process of preparing a degradable electrospinning film is uniaxial electrospinning, which constitutes a degradable electrospinning process. The electrospinning fiber of the membrane is a polyvinyl alcohol monolayer structure loaded with chemotherapeutic drugs, and the prepared biocompatible stent does not have a composite stent loaded with tumor blood vessel blocking drugs.

Embodiment 3

[0096]This example 3 provides a preparation method of a degradable electrospinning film, the difference between the preparation method and example 1 is that no 3D printing is performed and biocompatible scaffolds are stacked on both sides of the degradable electrospinning film .

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Abstract

The invention belongs to the technical field of medicine carrying platforms, and particularly relates to a multifunctional composite stent and a preparation method and application thereof. Wherein the multifunctional composite stent has the characteristic of programmed release of therapeutic drugs, the tumor vascular blocking drugs loaded on the stents on the two sides can preferentially and rapidly release and damage tumor tissue vascular endothelial cells so as to cause necrosis of part of cancer cells in the tumor, and then the intermediate electrostatic spinning membrane releases chemotherapeutic drugs permanently, so that the tumor tissue vascular endothelial cells are damaged. The degradable electrostatic spinning membrane loaded with the chemotherapy drug can act on residual tumor cells for a long time, effectively kills the residual tumor cells and reduces the tumor recurrence rate, and the biocompatible stent loaded with the tumor blood vessel blocking drug is overlaid on the two sides of the degradable electrostatic spinning membrane loaded with the chemotherapy drug to form a sandwich structure; the technical problems that residual tumor cells are difficult to effectively kill and the tumor recurrence rate is high in the prior art are solved.

Description

technical field [0001] The present application belongs to the technical field of drug-carrying platforms, and in particular, relates to a multifunctional composite scaffold and a preparation method and application thereof. Background technique [0002] Due to the influence of various factors such as environmental pollution, bad living habits, diet and age, the incidence of cancer is increasing year by year. Cancer, as a malignant tumor, has a low survival rate. Low. [0003] At present, surgical resection of cancer lesions and endocrine therapy are the preferred treatments for prostate cancer. Among them, surgical resection of lesions is suitable for localized prostate cancer, and cancer lesions can be completely removed by surgery. However, postoperative chemotherapy for malignant tumors, such as intravenous Injection administration or tumor resection lesion infiltration administration is difficult to reach the tumor site, the effective drug circulation is small, the actio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/704A61K47/32A61K47/34A61P35/00B33Y10/00B33Y70/10B33Y80/00A61K31/09
CPCA61K9/70A61K47/34A61K47/32A61K31/09A61K31/704A61P35/00B33Y80/00B33Y70/10B33Y10/00A61K2300/00
Inventor 李明强方友强陶玉柳政王海霞罗兴许彦腾
Owner THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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