Method for purifying cyclovirobuxinum D and preparation thereof

A cycloviral buxicine and purification method technology, applied to medical preparations containing active ingredients, organic chemistry, pharmaceutical formulas, etc., can solve the problems of small toxic and side effects, low effective rate, slow drug effect, etc.

Inactive Publication Date: 2004-12-29
南京小营药业集团有限公司
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AI Technical Summary

Problems solved by technology

The applicant extracts the active ingredient from the natural plant boxwood - boxwood (containing about 70% cyclovirboxic star), through more than 20 years of clinical proof, boxwood has anti-myocardial ischemia, reduces myocardial oxygen consumption, Improve myocardial hypoxia capacity, i

Method used

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preparation example Construction

[0025] The preparation column in the separation and purification process of the present invention should be a silica gel column.

[0026] In the above step 3 of the present invention, the recovered cyclohexane can be used repeatedly, and the time for the sawdust-like boxwood to be soaked in the cyclohexane is more than 2 hours.

Embodiment

[0028] Take 300kg of boxwood sawdust, then add 30kg of alcohol and ammonia mixture, stir them evenly, and adjust the pH value to 7.5. The purpose of adding alcohol is to destroy the cell structure of boxwood so that the solvent can penetrate into the cells of boxwood. Soak the stirred boxwood in 200kg of cyclohexane, let it stand overnight, then filter out the boxwood sawdust, concentrate and recycle the filtered cyclohexane liquid, place the concentrated dilute paste to crystallize, and recycle Cyclohexane can be applied repeatedly. The above-mentioned crystals were collected by filtration and washed with acetone to obtain about 30 g of Buyangning. To prepare mobile phase, 99.9ml of chloroform and 0.1ml of triethylamine can be used to prepare 100ml of mobile phase, or 99.95ml of n-hexane and 0.05ml of triethylamine can be used to prepare 100ml of mobile phase, or 50ml of chloroform, 49.91ml of Prepare 100ml mobile phase with n-hexane and 0.09ml triethylamine, or prepare 100m...

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PUM

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Abstract

The invention refers to a purifying method of Chinese patent drug curing cardiovascular and cerebrovascular disease and preparation of the Chinese patent drug. It uses boxwood as raw material, crushes the boxwood into sawdust, wets and stirs evenly the sawdust by alcohol and ammonia to make pH alkaline; or, dips the sawdust by alcohol and ammonia to make pH alkaline, then filters to eliminate dipping liquid; then dips the sawdust in cyclodexane, filters to get cyclodexane, concentrates and recovers the cyclodexane to get dilute paste body and then places to crystallize, filters to get the crystal and washes by acetone to get boxnine, dissolves the boxnine by flowing phase, then pumps in making column to separate and purify, in sections collects and then makes concentration, crystallization and drying to get high-purity circular dimensional boxstar D.

Description

technical field [0001] The invention relates to a purification method of a Chinese patent medicine for treating cardiovascular and cerebrovascular diseases and its preparation. Background technique [0002] Cardiovascular and cerebrovascular diseases are common and frequently-occurring diseases, and all patients need to be treated with drugs. The applicant extracts the active ingredient from the natural plant boxwood - boxwood (containing about 70% cyclovirboxic star), through more than 20 years of clinical proof, boxwood has anti-myocardial ischemia, reduces myocardial oxygen consumption, Improve myocardial hypoxia capacity, improve coronary circulation, reduce the size of myocardial infarction, enhance myocardial contractility, prevent arrhythmia and other aspects have achieved a certain effect, and the side effects are small, it is usually made into tablets for clinical use, its efficacy Slower and less efficient. Contents of the invention [0003] The purpose of the ...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P9/10C07J53/00
Inventor 杭太俊夏和柱刘洁张正行袁厚亮李泓
Owner 南京小营药业集团有限公司
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