Synthetic method for fluoromethylation of alcohols

A technology of fluoromethylation and halohydrin, which is applied in the field of fluoromethylation of halohydrin, and can solve problems such as expensive, low yield of fluorinated products, and influence on reversible regulation
CN1205159CInactive Publication Date: 2005-06-08ABBOTT LAB INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ABBOTT LAB INC
Publication Date
2005-06-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a method for fluoromethylation of haloalcohols. The method includes providing the formula R 1 C(CX 3 ) 2 The α-halohydrin step of OH, where R 1 selected from hydrogen, alkyl. The α-halohydrin and the chemical formula are CH 2 (OR 2 ) 2 The first compound reacts in the presence of an acid catalyst to form an acetal. The resulting acetal is chlorinated with a chlorinating agent to form the formula R 1 C(CX 3 ) 2 OCH 2 Chloride of Cl. The chloride is then converted to the chemical formula R with a fluorinating agent 1 C(CX 3 ) 2 OCH 2 Fluoride of F.
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Description

field of invention

[0001] The invention relates to a method for fluoromethylation of haloalcohols. Alcohols are reacted with dialkoxymethane under acidic conditions to give acetals which are then fluorinated by reaction with Lewis acids and fluorinating agents. The process yields high fluoride and can be performed in a single vessel. Preferably this method is used for the synthesis of sevoflurane from hexafluoroisopropanol. Background of the invention

[0002] Anesthetics are biochemical sedatives that affect the vital functions of cells. Anesthetics generally produce analgesia, loss of consciousness, decreased reflex activity, and muscle relaxation with minimal suppression of vital functions. Anesthetics can be gaseous (volatile) or solidified (nonvolatile). Gaseous anesthetics are inhaled and passed through the lungs into the bloodstream, while coagulated anesthetics are administered parenterally or through the digestive tract.

[0003] Many gaseous anesthetics in cur...

Claims

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