Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Topical compositions comprising ascomycins

A kind of technology of ascomycin and composition, applied in the field of topical composition, can solve problems such as difficulty

Inactive Publication Date: 2005-08-10
迈德制药卢森堡有限公司
View PDF16 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Particular difficulties arise with topical compositions containing ascomycin for the treatment of lichenified skin conditions such as psoriasis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 11

[0117] Prepare an ointment (in g) with the following composition

[0118] Compound A 1

[0119] Urea 10

[0120] Petrolatum 39

[0121] Microcrystalline Wax 10

[0122] liquid paraffin 35

[0123] Isopropyl myristate 5

[0124] total 100

[0125] The composition was prepared as follows: Compound A and urea were suspended in liquid paraffin and isopropyl myristate and heated to about 70°C. The white petrolatum and microcrystalline wax were heated to about 85°C, cooled to about 70°C, and slowly added to the above ascomycin mixture. The composition was then cooled to room temperature. Form into an ointment.

[0126] A total of 20 patients were treated for 3 weeks. The therapeutic effect of the composition on erythema, induration and scaling was evaluated from three clinical signs. In addition, the time to partial disappearance of symptoms was used to evaluate effectiveness. Local tolerability and routine safety parameters of the studied dosing regimens, including hema...

Embodiment 1

[0127] The formulation of Example 1 is effective. Local tolerability of the tested study dosing regimens was good, and no systemic adverse effects were observed.

Embodiment 12

[0129] An ointment having the same composition as the composition of Example 1.1 was prepared. The composition is obtained by heating liquid paraffin, microcrystalline wax, white petrolatum and isopropyl myristate to about 85°C, cooling to about 70°C, and suspending compound A and urea in the obtained mixture. The composition was then cooled to room temperature. Form into an ointment.

[0130] Example 2 3 4 5 6 7

[0131] Compound A 1 0.1 1 2 2 1.5

[0132] Substance that retains moisture in the outer layer of the skin

[0133] Urea 5 0.1 10 7.5 10 2

[0134] Substances that prevent moisture from evaporating from the skin

[0135] Petrolatum 44 99.8 84 85.5 86 73

[0136] Microcrystalline wax 10 - - - - -

[0137] Liquid paraffin 35 - - - - 20

[0138] liquid substance

[0139] Isopropyl myristate 5 - - - - -

[0140] Diisopropyl adipate - - 5 - - -

[0141] Oleyl Erucate - - - - - 3.5

[0142] Oleyl alcohol - - - 5 - -

[0143] Propylene glycol - - - - 2 -

[01...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
melting pointaaaaaaaaaa
Login to View More

Abstract

The present invention relates to a composition for topical administration comprising an ascomycin and a carrier vehicle vehicle comprising means to retain water in the outer skin layer and means to hinder water evaporating from the skin.

Description

technical field [0001] The present invention relates to topical compositions containing ascomycin for the treatment of skin disorders, such as subacute and chronic inflammatory and hyperproliferative skin disorders, such as atopic dermatitis, vitiligo, psoriasis, moss Ringworm-like skin diseases such as lichen planus, lichenified form of atopic dermatitis. Background technique [0002] Ascomycin has several useful pharmacological effects, such as immunosuppression, and it can be administered topically. However, ascomycins pose problems for topical application, especially because of their physicochemical properties, such as high molecular weight and lipophilicity. [0003] Skin diseases, especially lichenification skin diseases such as psoriasis, also have difficulties in treatment. In said disease, the skin is hyperproliferated and the skin barrier function and lipid composition of the skin may be altered. Topical compositions containing ascomycin fo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/04A61K9/00A61K31/4353A61K31/436A61K31/445A61K47/00A61K47/02A61K47/06A61K47/10A61K47/12A61K47/14A61K47/16A61K47/32A61K47/44A61P17/00A61P17/06A61P29/00A61P31/00A61P37/00A61P37/06
CPCA61K47/02A61K47/06A61K47/16A61K31/4353A61K31/436A61K47/44A61K47/12A61K9/0014A61K47/10A61K47/14A61P17/00A61P17/06A61P29/00A61P31/00A61P35/00A61P37/00A61P37/06
Inventor K·克里威特D·莱德格伯J·里德尔
Owner 迈德制药卢森堡有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com