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Preparation method of composite magnetic particle

A composite magnetic and magnetic particle technology, applied in the direction of magnetic objects, magnetic materials, circuits, etc., can solve the problems of magnetic particles easily detached from microspheres, product failure, and magnetic particles easy to fall off, etc., to achieve good biocompatibility and prolong use Long life and wide range of applications

Inactive Publication Date: 2005-10-26
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

From the application point of view, first of all, the poor biocompatibility of polymer materials makes it only suitable for in vitro separation and cannot be used for in vivo drug delivery.
In addition, the structure of polymer microspheres is usually relatively loose, and the magnetic particles contained in them are easy to detach from the microspheres during long-term storage, thus affecting the performance of the product
Generally, the polymer microspheres obtained by emulsion polymerization are large in size, mostly in the micron range, which cannot meet the requirements of some application fields that require smaller particles.
Another type of magnetic particle coating material commonly used is polysaccharide molecules, such as dextran, chitosan, etc., but the coating layer formed by such molecules is more unstable, and its interaction with magnetic particles is weak, and the same There is a disadvantage that the magnetic particles are easy to fall off and cause product failure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 16.62 grams of FeCl 3 and 9.93 g FeCl 2 , dissolved in 250ml of deoxygenated high-purity water, added to 5L of 5% ammonia water under strong stirring, filtered after stirring for 30 minutes, washed the precipitate with high-purity water, and then added 300ml of 23% tetramethylammonium hydroxide solution, stirred In 30 minutes, add high-purity water to a volume of 2.5L to obtain Fe 3 o 4 A sol with a concentration of 1.7g / L. Get above-mentioned sol 1.69L and pH be that the concentration of 9.5 is the SiO of 0.58% 2 Mix 310ml of aqueous solution, adjust the pH of the solution to 10 with 0.5M hydrochloric acid, stir for 3 hours, mix with a solution containing 168ml of 25% concentrated ammonia water, 4720ml of ethanol, and 4ml of ethyl orthosilicate, stir for 30 minutes, add 46.5 Fe with a concentration of 1.7g / L in ml 3 o 4 Sol, after stirring for 6 hours, SiO with a particle size of 50 nm was obtained 2 coated magnetic particles. Continue to add 1 ml of disso...

Embodiment 2

[0015] The particle diameter that obtains according to embodiment 1 operation is the SiO of 50nm 2 After coating the magnetic particles, continue to add 4ml orthosilicate ethyl ester, after stirring for 4 hours, obtain the SiO with a particle size of 100nm 2 coated magnetic particles. Then 1 ml of epoxytetraethoxysilane was added, and the stirring was continued for 2 hours to obtain composite magnetic particles with surface-modified epoxy groups.

Embodiment 3

[0017] The particle diameter that obtains according to embodiment 2 operation is the SiO of 100nm 2 After the coated magnetic particles, continue to add 8ml orthosilicate ethyl ester, after stirring for 8 hours, the SiO particles with a particle size of 300nm are obtained. 2 coated magnetic particles. Then 1 ml of aminopropyltetraethoxysilane was added, and the stirring was continued for 2 hours to obtain composite magnetic particles with amino groups modified on the surface.

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Abstract

A composite magnetic particle for biologic and medical purposes is prepared from (5-8)-nm superparamagnetic Fe3O4 crystals as kernel, coating SiO2 layer twice in water phase and organic phase, and modifying particle surface by silanizing agent. Its advantages are high biologic compatibility, firm binding of kernel, and wide application range.

Description

Technical field: [0001] The invention relates to a preparation method of composite magnetic particles which can be used for biological separation, detection and directional delivery of drugs. Background technique: [0002] The application of composite magnetic particles in the biological field has attracted increasing attention. Its main application field is as a separation medium for magnetic field separation of biological samples. The biological activity is now more and more widely used. In addition, using the characteristics of directional movement of composite magnetic particles under a magnetic field, there are also reports on the directional delivery of drugs in vivo or directional adsorption to the lesion to directly treat diseases. The latter has attracted people's attention because of its potential in the treatment of cancer and other diseases . When magnetic particles are used in biological detection, especially immunochromatographic detection, the elimination of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F1/02C04B35/624H01F1/00
Inventor 杨文胜庄家骐杨百全白玉白李铁津
Owner JILIN UNIV
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