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Chinese medicine positioning preparation for treating ulcerative colitis

A colon locating preparation, a technology for ulcerative colitis, which is applied in the directions of drug delivery, drug combination, and pharmaceutical formulation, can solve the problems of inconvenient Chinese medicine enema treatment methods, affect patient compliance with treatment, affect the use of chemical drugs, etc. Systemic adverse reactions, improved compliance, and the effect of convenient treatment

Inactive Publication Date: 2006-01-18
BEIJING ZHONGHUI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Because the disease is easy to relapse, long-term medication is required, and the side effects will affect the use of chemical drugs
Most patients require traditional Chinese medicine treatment. There are many traditional prescriptions that use decoction to treat ulcerative colitis with traditional Chinese medicine. The general effect is not ideal, and there are certain side effects on the gastrointestinal tract
Treating ulcerative colitis with traditional Chinese medicine enema has the advantages of quick effect and safety. At present, there are many compound preparations of traditional Chinese medicine enema for clinical treatment of ulcerative colitis, but the treatment method of traditional Chinese medicine enema is very inconvenient, which affects the compliance of patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Take 150 grams of Sophora flavescens, 60 grams of licorice root, and 150 grams of Sanguis sylvestris and decoct them together, mix the decoction with 60 grams of white and powder evenly, dry, pass through a 60-mesh sieve, and put them into ordinary capsules. The capsule capacity is 0.6 grams. / grain. The pH-dependent colon positioning coating film is wrapped, and the coating liquid uses 50 grams of acrylic resin, 2200 grams of ethanol, 25 grams of diethyl phthalate, and 24 grams of talc. After clinical trials, oral administration twice a day, 5 capsules each time, 7 days as a course of treatment. Observe 1-4 courses, the total effective rate is 75%.

Embodiment 2

[0033] Example 2: Take 120 grams of Phellodendron chinense, 150 grams of Sophora flavescens, 150 grams of Sanyu 150 grams, and 60 grams of licorice to decoct. The decoction is dried and passed through a 60-mesh sieve. After clinical trials, oral administration twice a day, 5 capsules each time, 7 days as a course of treatment. Observing 1-4 courses of treatment, the total effective rate was 71%.

Embodiment 3

[0034] Example 3: Take 120 grams of Sanyu and 120 grams of Phellodendron amurense to decoct in water, dry the decoction, and mix with 200 grams of Baiji, pass through a 60-mesh sieve, and fill in ordinary capsules, each containing 0.6 grams. Outer PH-dependent colon positioning coating film, the coating liquid adopts polymethacrylate EUDRAGIT  S 100: 65 grams, 32 grams of talc, 5.8 grams of triethyl citrate, 55 grams of water, and 900 grams of isopropanol. After clinical trials, oral administration twice a day, 5 capsules each time, 7 days as a course of treatment. Observe 1-4 courses, the total effective rate is 88%.

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Abstract

The present invention relates to a Chinese medicine location preparation for curing ulcerative colitis. It is formed from colon location capsule and Chinese medicine compound preparation for curing ulcerative colitis which is held in the capsule. Said capsule does not disintegrated in the stomach and small intestine, and in the colon region whose pH value is greater than or equal to 7.8 it is disintegrated, and the medicine can be released. Said invention can effectively raise the biological utilization rate of the medicine, and its therapeutic effect is obvious. After the prescription of said medicine is changed, it can be used for curing other disease of colon region.

Description

Technical field [0001] The invention belongs to the technical field of Chinese medicine type, and particularly relates to a dosage form applied to treat colitis. Background technique [0002] Ulcerartive colitis (UC) is a chronic colitis of unknown cause, which is customarily called chronic non-specific ulcerative colitis, or ulcerative colitis. The disease currently has a gradual increasing trend and is a difficult disease. [0003] After the first attack of the disease, about 10% of patients can be relieved and can be maintained for 15 years. Another 10% of patients can continue to suffer from active colitis for a long time. In most other patients (80%), remission can alternate with seizures, and they will not heal for a long time. It can become cancerous in the late stage, which is very scary. Long-term consumption and torture have caused strong mental and physical damage to the patient. [0004] Currently there is no specific treatment. Commonly used western medicines include...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/756A61K35/64A61K9/58A61P1/04
Inventor 朱德权梁秉文马建国
Owner BEIJING ZHONGHUI PHARM CO LTD
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