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Liquid filtering method and filtering system

A filtration method and filtration system technology, applied in the direction of filtration separation, separation method, chemical instrument and method, etc., can solve problems such as poor welding, reduced pressure resistance, increased manufacturing cost, etc., and achieve improved removal performance and high removal performance , the effect of good flow rate

Inactive Publication Date: 2006-03-29
ASAHI KASEI MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as described in JP-A-11-216179, the method of inserting the connecting rod or the mesh screen has the risk of causing poor welding of the container due to the need to insert another member, and the manufacturing process also becomes complicated. , due to the use of more materials, there is also the problem of increased manufacturing costs
[0011] Furthermore, with the method of using connecting rods, the range of the effect of preventing close adhesion may be limited to the vicinity of the connecting rods, and its effect is also in doubt.
In addition, the method of forming unevenness on the inner surface of the container shown in JP-A-11-216179 is proposed as a countermeasure to solve the problem of the method of inserting the connecting rod or the mesh screen. In the case of directly welding the container material and the filter element Under the circumstances, there are irregularities on the inner surface of the container, which may easily cause poor welding and reduce the risk of pressure resistance. Therefore, its applicability in frame welding type filters is limited.
[0012] As mentioned above, in the prior art, the method of disposing a spacer (sparrow) for leaving a gap that can become a blood channel between the container to be closely bonded and the filter element is used to solve the problem caused by the filter outlet. The adverse situation caused by the negative pressure generated on the outlet side, that is, how to alleviate the problem of close adhesion between the outlet side container and the filter element, may not be able to be satisfied.

Method used

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  • Liquid filtering method and filtering system
  • Liquid filtering method and filtering system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0070] Embodiment 1~3 and comparative example 1~9

[0071] A filter (K=4445.5Pa) consisting of a flexible container with a liquid inlet and an outlet and a sheet filter element that does not actually contain a spacer to prevent the close contact between the outlet side container and the filter element is used -1 , Af=43.5×10 -4 m 2 ), and its liquid inlet is connected to the liquid storage bag before filtration through a 1.0m-long upstream flow path. The liquid outlet of the filter is connected to the filtered liquid recovery bag through a 1.0 m long downstream flow path. Further, a tube for pressure measurement and a pressure gauge (manufactured by Copal Electric Co., Ltd.) were connected to the nearest part of the filter to the liquid outlet through a T-shaped tube. A flexible polyvinyl chloride sheet with a thickness of 0.37 mm is used for the flexible container, and soft polyvinyl chloride with an inner diameter of 2.9 mm and an outer diameter of 4.2 mm is used for the ...

reference example 1～2

[0074] Instead of the flexible container, a filter was produced with a rigid container made of polycarbonate, and filtration was performed in the same manner as in Example 1 and Comparative Example 9 except that this filter was used. Moreover, the height difference between the liquid inlet and the liquid outlet of the rigid container is 0.15m. When the filter is made of a rigid container, the actual flow velocity does not change whether the pressure at the outlet of the filter is a negative pressure or a positive pressure.

[0075] The results of Examples 1-3, Comparative Examples 1-9, and Reference Examples are collectively shown in Table 1 now.

[0076] Example 1

[0077] Comparative example 3

Embodiment 4

[0078] Embodiment 4 and Comparative Examples 10-11

[0079] The length of the flow path on the upstream side (the same as the head drop on the upstream side) was fixed at 75 cm (Example 4), 55 cm (Comparative Example 10), and 45 cm (Comparative Example 11), and fluorescent particles (average diameter 2.5 μm) were suspended in Concentration 6.0×10 6 (unit / ml) polyvinylpyrrolidone aqueous solution (viscosity: 28.3 mPa·s), except that the same filtration as in Example 1 was performed, and the outlet pressure, flow velocity, and particle removal rate of each filter were measured. As for the removal rate of particles, the value obtained by dividing the fluorescence intensity of 150 ml of the first filtrate by the fluorescence intensity before filtration was obtained, and the logarithmic removal rate was obtained by multiplying the log value by -1. When measuring the actual fluorescence intensity, measure the pre-filtered solution and the filtered solution after diluting or concent...

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Abstract

A filtering method which prevents adhesion between an outlet vessel and a filter element and which uses a flexible filter which allows smooth flow of liquid and is superior in filtering performance; and a filtering system. A filtering method which uses a flexible vessel having an inlet and an outlet for liquid, a sheet-like filter element, and a filter in which the inlet and outlet for liquid are separated by the filter element, wherein in filtering a liquid by the action of gravity or of a liquid feed pump, the pressure in the outlet of the filter is not less than 0 mmHg with respect to the atmospheric pressure; and a filtering system. Further, a filtering method in which a suitable combination of the filter and the hydrodynamic characteristics of the flow channel upstream or downstream of the filter is selected to make the pressure in the outlet of the filter not less than 0 mmHg with respect to the atmospheric pressure; and a filtering system.

Description

technical field [0001] The present invention relates to a liquid filtration method and a filtration system for removing unnecessary components such as aggregates and white blood cells from liquid such as blood. In particular, it relates to a blood filtration method and a blood filtration system using a blood treatment filter for removing fine aggregates or leukocytes that cause side effects of blood transfusion from whole blood preparations, red blood cell preparations, platelet preparations, plasma preparations, etc. for blood transfusion. Background technique [0002] Whole blood collected from blood transfusion recipients is seldom transfused as it is. Generally, it is separated into red blood cell preparations, platelet preparations, plasma preparations and other components, which are stored before transfusion. In addition, since minute aggregates or leukocytes contained in these blood preparations are responsible for various side effects of blood transfusion, there is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D37/00A61M1/34A61M1/02A61M1/36
CPCA61M1/3633A61M2001/3636A61M2001/0218A61M1/0209A61M1/3636A61M1/0222A61M1/0231A61M1/34A61M2205/3331A61M2202/0413
Inventor 横沟朋久内幸彦
Owner ASAHI KASEI MEDICAL CO LTD
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