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Isatis root extract, and preparing method and use thereof

A kind of Radix isatidis extract and extract technology, applied in application, food preparation, food science and other directions, can solve the problems of many categories of ingredients, low relative content of antiviral active components, limited types of Radix Isatidis preparations, etc. low cost effect

Inactive Publication Date: 2006-04-12
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the research on the extraction process of Radix Isatidis above, the water extraction and alcohol precipitation process mentioned in "Chinese Pharmacopoeia" is simple, and there are many types of components in the obtained extract, and the relative content of antiviral active components is low, which leads to a large dose of Radix Radix Radix preparation, and at the same time It also limits the types of preparations of Radix Isatidis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 100Kg of Radix Isatidis and decoct it twice with 10 times the amount of water, the first time is 2 hours, the second time is 1 hour, and the decoction liquid is combined. After filtering, the filtrate is concentrated to the flow extract (1) with a relative density of 1.10 at 50℃, 30L ethanol is added to the flow extract (1), and the ethanol concentration is measured to be 70%. The precipitate is precipitated, and the supernatant is taken Concentrate to no alcohol taste to obtain extract (2) (number IsiL), extract (2) add 20L of methanol and acetone mixed solvent to extract 3 times each time, recover the solvent from the extract, and concentrate to obtain extract (3) (relatively The density is 1.10), and 8.6Kg of active extract (No. HG) is obtained, and its adenosine content is determined by HPLC analysis method to be 2.56% (based on the dry extract). The residue after methanol-acetone extraction is concentrated to remove methanol and acetone, and diluted with water to ...

Embodiment 2

[0035] "+" is the disease

[0036] The results show that the antiviral activity of the dry powder of Radix Isatidis extract obtained by the invention is significantly stronger than that of the dry paste powder extracted by the original process.

Embodiment 3

[0038] medicine

[0039] The results showed that the newly prepared Banlangen granules and Banlangen tablets had stronger antiviral activity than the original Banlangen granules. The original Isatis root particles and Isatis root tablets have significant antiviral activity under the conditions of lower experimental concentration and high virus titer; while the original Isatis root particles have antiviral effects only at high concentration and low virus titer. obvious.

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PUM

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Abstract

The present invention relates to isatis root extract, its preparation method and its application, belonging to the field of medicine, food and health-care product. Said preparation method includes the following steps: making isatis root or crucifer isatis tinctoria undergo the processes of water extraction and alcohol precipitation treatment to obtain concrete, then using 10-50 times polar mixed solvent to make extraction to obtain extractive liquor, recovering solvent and concentrating to obtain its active extract. The determination shows that said extract contains lots of nucleoside with activity for resisting virus, its content is 5.2%-28.0%, its adenosine content is 1.10-2.80% (by dried extract product). Said extract can be used for preparing antiviral medicine, food and health-care product, can be made into granules, tablet, capsule preparation and solution preparation, etc.

Description

Technical field [0001] The invention relates to a medicine derived from plant raw materials and a preparation method and application thereof, belonging to the fields of medicine, food, and health care products, and specifically relates to the antiviral active ingredient of the Chinese medicine Radix Isatidis and a preparation method. Background technique [0002] Radix isatidis is the root of the cruciferous plant Isatis indigotica Fort. It has the effects of clearing heat, detoxifying, cooling blood and throat. The extraction process of Radix Isatidis preparations such as Radix Isatidis granules and Radix Isatidis tea recorded in the Chinese Pharmacopoeia (1990-2000) is to take the decoction of Radix isatidis and add ethanol to make the concentration 60%. After removing the precipitation, take the supernatant to concentrate and add Made of accessories. There are also literature reports on the extraction process of Isatis indigotica, "Screening of the effective parts of Isatis in...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/31A61K31/7076A61P31/12A23L1/30A61K125/00A23L33/105
Inventor 李楚源曾令杰陈矛
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE