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Total flavone extracting method from above-ground part of licorice

A technology of aerial parts and total flavonoids, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., to achieve the effect of simple process

Inactive Publication Date: 2006-08-30
NAT INST OF PHARMA R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, while protecting resources, everyone ignores the issue of how to make limited resources more effective

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 (reflux extraction)

[0018] With 5000 grams of Radix Glycyrrhizae aerial parts, take 60 kilograms of 50wt% ethanol (all the other being water) as solvent reflux extraction 3 times; Merge the extract, reclaim the ethanol wherein; After the aqueous solution stands and precipitates completely, get the supernatant; Then the supernatant The liquid is separated with a D-101 type macroporous resin column, washed with water to remove impurities and then eluted with ethanol, and finally the eluate is dried to obtain 119 grams of total flavonoids in the aerial parts of licorice, with a yield of 2.38%. was 51%.

Embodiment 2 and 3

[0020] Other conditions are the same as in Example 1, and the number of times of extraction is 2 (Example 2) and 1 (Example 3). In Example 2, the yield is 2.26%, and the total flavone content is 48%. In Example 3, the yield is 2.01%, and the total flavone content is 41%.

Embodiment 4

[0021] Embodiment 4 (cold infiltration extraction)

[0022] Extract 5000 grams of licorice aerial parts with ethanol as a solvent for 3 times, soak the licorice aerial parts with 40 kg of ethanol at a temperature of 25 ° C, and then extract by percolation; combine the extracts, reclaim the ethanol; centrifuge the aqueous solution, separate Take the supernatant; then the supernatant is separated with a DA201 type macroporous resin column, washed with water to remove impurities and then eluted with ethanol, and finally the eluent is dried to obtain 103 grams of total flavonoids in the shoots of licorice, with a yield of 2.06 %, the total flavonoid content is 45%.

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PUM

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Abstract

The invention discloses a process for extracting total flavone of overground portion of liquorice comprising the steps of, extracting the overground portion of liquiorice 1-3 times with organic solvent through one of the extractions including cold permeating, warm soaking or backflow, combining the extract liquid, reclaiming the organic solvent therein, separating the extract with removed organic solvent with resin columns, water scrubbing to remove impurity and carrying out elution with organic solvent, drying the eluent to obtain the total flavone of overground portion of liquorice. The invention realizes simple process and both high yield and high content of total flavone of overground portion.

Description

technical field [0001] The invention relates to a method for extracting total flavonoids from the aerial parts of licorice. Background technique [0002] The traditional Chinese medicine licorice is the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L., which is the most frequently used and most widely used Traditional Chinese medicine, so its market demand is very large. But over the years, due to people's excessive excavation, not only the vegetation resources in our country have been severely damaged, resulting in a sharp reduction of resources, but also a large number of soil desertification, and the ecological environment has also been damaged. For this reason, the state has issued a series of policies to control the excavation of wild licorice and encourage the cultivation of licorice. However, while protecting resources, everyone has neglected the issue of how to make limited resources more effective. Because ...

Claims

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Application Information

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IPC IPC(8): C07H17/07C07H1/08
Inventor 苑可武
Owner NAT INST OF PHARMA R & D CO LTD