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Kidney preservative fluid

A technology of preservation solution and kidney, which is applied in the field of medical devices, can solve the problems of not enough to prevent cell acidification, purity not up to pharmaceutical standards, high viscosity, etc., to achieve outstanding resistance to ischemia-reperfusion injury and reduce ischemia-reperfusion injury. Perfusion injury, the effect of increasing SOD activity

Inactive Publication Date: 2006-09-06
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] But this preservation solution also has its inherent deficiencies: 1. The concentration of magnesium sulfate is high, and it is easy to precipitate at low temperature, and it precipitates in the preservation solution and renal blood vessels to cause tissue damage; 2. It does not contain effective buffer pairs, and the pH value is unstable. Time (more than 24 hours) is not enough to prevent cell acidification when storing the kidney; 3. It contains more biochemical agents, and the purity cannot meet the medicinal standard
However, the formula of UW liquid is not impeccable. Its viscosity is too high, so the cooling speed is slow, and the potassium ion content is too high. Improper use will cause cardiac arrest during surgery. More importantly, it is very expensive and not suitable for our country. national conditions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: Prepare preservation solution I (1000ml).

[0042] 1. Add 800ml of double distilled water to the 1000ml container;

[0043] 2. Add 6488mg potassium citrate and stir to dissolve it;

[0044] 3. Add 6764mg of sodium citrate and stir to dissolve it;

[0045] 4. Add 2465mg of magnesium sulfate and stir to dissolve it;

[0046] 5. Add 5372 mg of disodium hydrogen phosphate and stir to dissolve it;

[0047] 6. Add 270mg sodium dihydrogen phosphate, stir to dissolve;

[0048] 7. Add 535 mg of adenosine and stir to dissolve it;

[0049] 8. Add 350mg L-arginine and stir to dissolve it;

[0050] 9. Add 30g of mannitol and stir until completely dissolved;

[0051] 10. Capacity adjustment: add double distilled water until the total volume of the solution is 1000ml, stir to make the solution a uniform, colorless and clear liquid;

[0052] 11. After activated carbon filtration, seal the filtrate and sterilize under high temperature and high pressure (109°C, 45 minu...

Embodiment 2

[0053] Embodiment 2: preparation preservation solution II (1000ml).

[0054] 1. Add 800ml of double distilled water to the 1000ml container;

[0055] 2. Add 2578mg potassium citrate, stir to dissolve;

[0056] 3. Add 10284mg of sodium citrate and stir to dissolve it;

[0057] 4. Add 5679mg of magnesium sulfate and stir to dissolve it;

[0058] 5. Add 5372 mg of disodium hydrogen phosphate and stir to dissolve it;

[0059] 6. Add 270mg sodium dihydrogen phosphate, stir to dissolve;

[0060] 7. Add 1070mg adenosine, stir to dissolve;

[0061] 8. Add 350mg L-arginine and stir to dissolve it;

[0062] 9. Add Ligustrazine 4mg, stir to dissolve;

[0063] 10. Add 30g of mannitol and stir until completely dissolved;

[0064] 11. Capacity adjustment: Add double distilled water until the total volume of the solution is 1000ml, stir to make the solution a uniform, colorless and clear liquid;

[0065] 12. After activated carbon filtration, seal the filtrate and sterilize under hig...

Embodiment 3

[0066] Embodiment 3: Preparing preservation solution III (1000ml).

[0067] 1. Add 800ml of double distilled water to the 1000ml container;

[0068] 2. Add 6488mg potassium citrate and stir to dissolve it;

[0069] 3. Add 6764mg of sodium citrate and stir to dissolve it;

[0070] 4. Add 14790mg of magnesium sulfate and stir to dissolve it;

[0071] 5. Add 5372 mg of disodium hydrogen phosphate and stir to dissolve it;

[0072] 6. Add 270mg sodium dihydrogen phosphate, stir to dissolve;

[0073] 7. Add 1605mg of adenosine and stir to dissolve it;

[0074] 8. Add 700mg L-arginine and stir to dissolve it;

[0075] 9. Add 30g of mannitol and stir until completely dissolved;

[0076] 10. Capacity adjustment: add double distilled water until the total volume of the solution is 1000ml, stir to make the solution a uniform, colorless and clear liquid;

[0077] 11. After activated carbon filtration, seal the filtrate and sterilize under high temperature and high pressure (109°C, ...

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PUM

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Abstract

The invention provides a kidney preservative fluid which comprises potassium citrate, sodium citrate, magnesium sulfate, disodium hydrogen phosphate, sodium dihydrogen phosphate, adenosine, L-arginine, ligustrazine and mannidex, which has the advantages of high penetrability, acidity stability, thus can prevent ischemia re-impregnating damage and conserve kidney as long as 72 hours.

Description

technical field [0001] The invention relates to the technical field of medical devices, and is a preservation solution for human or animal organs, tissues or cells, especially a kidney preservation solution. Background technique [0002] The large-scale development of kidney transplantation in my country began in the late 1970s and early 1980s, and one of the most important driving forces was the successful development of hypertonic adenine citrate (HCA) kidney preservation solution. The preservation solution can effectively preserve the kidney for 57 hours. For more than 20 years, this preservation solution has been widely used in medical units carrying out organ transplantation across the country, and has played an important role in the field of domestic kidney transplantation. (Refer to "Kidney Preservation Experimental Research and Clinical Application", Chinese Journal of Urology, 1982; 3(1): 17.) [0003] The composition and main technical parame...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N1/02
Inventor 朱有华张纯
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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