Medicine composition capable of benefiting vital energy, activating pulse, nourishing yin and promoting the secretion of the body fluid and preparation method thereof

Abstract

The invention discloses a pharmaceutical composition for nourishing qi and promoting pulse, nourishing yin and promoting body fluid and a preparation method thereof. It is composed of pharmaceutical excipients and prepared into injection preparations; it is also characterized in that the present invention limits the content of panaxadiol saponins, which have both good pharmacological effects and hemolytic adverse reactions, so that each group of preparations of the present invention can be more effective in clinical application. Safe; the results of pharmacological experiments show that the preparation of the pharmaceutical composition has better pharmacological effects and safety compared with commercially available drugs of the same kind.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a pharmaceutical composition for nourishing qi and promoting pulse, nourishing yin and promoting body fluid and a preparation method thereof. Background technique [0002] Ginseng is an Araliaceae plant, which has the functions of invigorating vital energy, rejuvenating the veins, nourishing the spleen and lungs, promoting body fluid and calming the nerves. Ginseng mainly contains ginsenosides, with a content of about 4%. It is divided into oleanolic acid according to different aglycones. Panaxadiols, Panaxadiols, Panaxatriols, Panaxadiol Saponins, Panaxatriol Saponins with very good pharmacological activity, monomer saponins have -R o 、RA o 、Ra 1 ,-Ra 2 ,-Ra 3 , -Rb 1 , -Rb 2 , -Rb 3 , -Rc, -Rd, -Re, -Rg 1 , -Rg 2 , -Rg 3 , -Rh 1 , -Rh 2 etc. Others are polysaccharides, amino acids, volatile oils, fatty acids, trace elements,...

AI Technical Summary

Problems solved by technology

[0003] Ginseng and Ophiopogon japonicus prescriptions are prepared into Shenmai injection, which is widely used in clinical practice and has achieved very good curative effect, which has been recognized by doctors and patients; through a large number of experimental studies, using the theory of traditional Chinese medicine, ginseng is used as the monarch drug, and the compatibility Ophiopogon japonicus, the system has the functions of nourishing qi and solidifying, nourishing yin and promoting body fluid, and promoting pulse. It is used to treat shock, coronary heart disease, viral myocarditis, chronic pulmonary heart disease, and neutropenia of Qi and Yin deficiency. The patent "Shenmai The application of injection in the manufacture of anticancer drugs" (application number 94107143) only briefly introduced the extraction of ginseng and Ophiopogon japonicus with ethanol, and did not elaborate on the extraction process; 94113809) introduced the simple ethanol extraction of ginseng and Ophiopogon japonicus, and the extract was processed by preparation and then freeze-dried to prepare freeze-dried powder. This method has been reported in early literature; 98112180) only briefly introduced the method of extracting ginseng and Radix Ophiopogon japonicus respectively with ethanol, and this method has also been reported in early documents; Resin chromatography column is used for purification, but there is no description of the type of resin column used, which cannot be implemented in reality, and the resin column needs to be performed twice, which is cumbersome and complicated