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Maka nano liposome and its preparing method

A nanoliposome and plastid technology, applied in the field of nanomedicine, can solve problems such as insolubility, and achieve the effects of less drug loss, good biocompatibility, and enhanced water solubility

Inactive Publication Date: 2006-11-08
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the development of new drugs, the poor solubility of its main components (macaene, macamide and fatty acids, etc.), and the resulting bioavailability problems have become more and more serious technical bottlenecks

Method used

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  • Maka nano liposome and its preparing method
  • Maka nano liposome and its preparing method
  • Maka nano liposome and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 30 mg of maca, 50 mg of cholesterol, and 200 mg of soybean lecithin into a round bottom flask, add 30 ml of a mixture of chloroform and ethanol with a volume ratio of 5:1 to dissolve, and evaporate under reduced pressure on a rotary evaporator to remove chloroform and ethanol. Add 10 ml of 60 g / L glucose solution as a dispersion medium to obtain a liposome primary mixture, and ultrasonicate in an ice-water bath for 10 min to obtain liposomes of 20-220 nm.

[0027] The analytical results of the prepared Maca nanoliposomes are as follows: Figure 2-7 shown.

Embodiment 2

[0029] Weigh 5 mg of maca, 50 mg of cholesterol, and 200 mg of soybean lecithin into a round bottom flask, add 30 ml of a mixture of chloroform and ethanol with a volume ratio of 5:1 to dissolve, and evaporate under reduced pressure on a rotary evaporator to remove chloroform and ethanol. Add 10 ml of 60 g / L glucose solution as a dispersion medium to obtain a liposome primary mixture, and ultrasonicate in an ice-water bath for 10 min to obtain liposomes of 20-220 nm.

Embodiment 3

[0031] Weigh 75 mg of maca, 50 mg of cholesterol, and 200 mg of soybean lecithin into a round bottom flask, add 30 ml of a mixture of chloroform and ethanol with a volume ratio of 5:1 to dissolve, and evaporate under reduced pressure on a rotary evaporator to remove chloroform and ethanol. Add 10 ml of 60 g / L glucose solution as a dispersion medium to obtain a liposome primary mixture, and ultrasonicate in an ice-water bath for 10 min to obtain liposomes with a diameter of 220-220 nm.

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Abstract

The invention discloses a Maca nano-liposome and a preparation method thereof, aiming to provide a nano-liposome with simple process, high drug utilization rate, stable physical properties, and can significantly improve the water solubility of the main component of Maca and its preparation method. its preparation method. Maca nanoliposome is characterized by: its surface is a phospholipid bilayer, the hydrophilic group outside the bilayer forms a hydrophilic cap, and the hydrophilic group inside the bilayer forms an inner water phase. The hydrophobic group between the bilayers creates a hydrophobic region, so a nanoliposome can embed hydrophobic components and hydrophilic components at the same time; the main component in Maca is hydrophobic, and it is embedded in the nanometer scale. Between the phospholipid bilayers of liposomes, the hydrophilic components of Maca are also loaded into the inner aqueous phase. The preparation method uses soybean lecithin with better biocompatibility as a carrier, glucose solution as a dispersion medium, and adopts a rotary thin film evaporation method to prepare Maca nano liposomes carrying insoluble plant drug Maca.

Description

Technical field: [0001] The invention belongs to the field of nanomedicine, and in particular relates to a method for processing plant drug Maca into nano liposomes with stable physical properties. Background technique: [0002] The herbal drug Maca is a brownish-yellow insoluble oily substance obtained by extracting the physiologically active components of the plant from Maca, a precious medicinal material called Andean ginseng, which is abundant in the high mountain regions of the Andes in South America. Maca can enhance physical strength, be energetic, eliminate anxiety, and improve sexual function. Recently, Maca frequently appears on the Internet or in newspapers and magazines at home and abroad, indicating that its health care function is favored worldwide. However, in the development of new drugs, the poor solubility of its main components (macaene, macamide and fatty acids, etc.), and the resulting bioavailability problems have become more and more serious technical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/31A61K9/127A61P1/14
Inventor 王柯敏谭蔚泓郑明彬吴萍龚萍何晓晓
Owner HUNAN UNIV