48results about How to "Little change in particle size" patented technology

The invention belongs to the technical field of medicine preparations, and particularly relates to a taxol freeze-dried powder preparation process and a product. The taxol freeze-dried powder preparation process is simple in route, production cost is low, transportation and storage is simple and convenient, and adverse reaction caused by addition of excipients is avoided. In-vitro stability of taxol micelle freeze-dried powder is higher, redissolved taxol solution is stably kept 12 hours or than at room temperature, and drug treatment requirements are met. Blood stability is higher, grain diameter is small, an EPR effect is more easily played, taxol freeze-dried powder can be redissolved by the aid of common normal saline or glucose injection, and drug administration processes are greatlysimplified.

The invention discloses a preparation method of water-soluble capsanthin and its products, which belong to the technical field of pigment processing. The method comprises the following steps: adding a cosolvent and an emulsifying carrier aqueous solution to the saponified capsanthin, After mixing and dispersing, the obtained dispersion liquid is homogenized to obtain the water-soluble capsanthin, and the co-solvent is glycerol, propylene glycol or ethanol; the method of the present invention can significantly improve the water solubility of capsanthin, and prepare The product can be miscible with water in any proportion, which greatly improves the application range of capsanthin; the water-soluble capsanthin prepared by the present invention has good stability, and after 30 days of dark storage, the product color value and particle size The change is small, maintained at a relevant stable level, and adopting the method of the present invention can significantly improve the effect of capsanthin on Cu 2+ , Fe 2+ , Fe 3+ Ions and stability to light and high temperature.

The invention discloses a dispersible pH sensitive cationic polymer gel sub-micron particle and making method, which comprises the following steps: allocating raw material through non-ion soluble macromolecular monomer, cation monomer, crosslinking agent and initiator weight rate at 20%-70%25%-75% 0.7%-3%0.7%-3%; dissolving in the acetonitrile or alcohol; aerating nitrogen to reflux; evaporating solvent; dripping secondary distill water; cooling dispersing liquid naturally; centrifuging to separate; dialyzing upper supernatant layer; freezing to drying; making the gel sub-micron particle disperse in the pure water, physiological saline and buffer as drug control carrier releasing material.

The invention provides a microemulsion droplet of a W / O / W type PCR amplified product based on a microfluidic system and a preparation method of the microemulsion droplet, the microemulsion droplet includes an amplified W / O type microemulsion droplet , an oil phase A and an outer water phase, wherein the amplified W / O microemulsion droplets include an inner water phase and an oil phase B, prepared by a microfluidic system, and the amplified W / O microemulsion droplets, oil phase A The volume ratio of the inner water phase to the outer water phase is 1:3:1000; the volume ratio of the inner water phase to the oil phase B is 40:3. The present invention provides a preparation method of W / O / W microemulsion droplets. The obtained microemulsion droplets can effectively establish a new type of microemulsion droplet sorting platform, and can effectively solve the problem of tissue The conundrum of cellular heterogeneity that samples cannot crack. In the present invention, by strictly screening the formula ratio and preparation parameters, the average particle diameter is 70 μm, all of which are spherical particles with uniform particle size distribution, and the stability experiment shows that the microemulsion droplets prepared by the present invention can be stored at room temperature, and The particle size changes little in a short time at room temperature.

The present invention discloses hyaluronic acid- g ‑Folic acid amphiphilic polymer and its application, the main chain is hydrophilic hyaluronic acid, and the side chain is hydrophobic folic acid, which can efficiently and stably load small molecule anticancer drugs and prolong the blood circulation time of drugs; The enrichment amount is high, reaching 12.0%ID / g. After reaching the tumor tissue, the dual-targeted nanomedicine tightly binds to the surface of tumor cells and effectively enters the tumor cells through receptor-mediated endocytosis, and then realizes The drug is released quickly, resulting in a highly effective therapeutic effect. The polymer of the present invention has good biocompatibility and degradability, and is convenient to be excreted from the body; it overcomes the shortcomings of low drug delivery efficiency, less accumulation in tumor sites, low cell endocytosis efficiency, and slow intracellular release; and the method is simple to prepare , the source of raw materials is abundant, and the obtained nanomedicine has excellent freeze-drying redispersibility, which is conducive to large-scale production and application.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a preparation process and product of paclitaxel freeze-dried powder. The preparation process of the paclitaxel freeze-dried powder has the advantages of simple route, low production cost, and easier and more convenient transportation and storage, and avoids adverse reactions caused by adding excipients. The prepared paclitaxel micelle freeze-dried powder has high stability in vitro, and a paclitaxel solution obtained through redissolution of the paclitaxel micelle freeze-dried powder remains stable at room temperature for more than 12 hours and meets the requirements of drug treatment. The paclitaxel freeze-dried powder has higher blood stability, smaller particle size, and is more likely to exert an ERP effect. The paclitaxel freeze-dried powder can be re-dissolved by use of an ordinary physiological saline or glucose injection, and thus the administration process is greatly simplified.

The invention discloses a preparation method and application of a nut oil micro-emulsion spray. When the nut oil micro-emulsion spray is prepared, firstly, Tween-60 and hydrogenated castor oil serve as a composite surfactant, polyethylene glycol and nut oil serve as a mixed oil phase, nut oil nano micro-emulsion is prepared, then a macadimia nut green husk extracting solution and the nut oil nanomicro-emulsion are mixed, high-speed shearing dispersion and filtration are carried out, 95% edible alcohol, menthol and / or borneol are added, finally, the material is degermed and filtered, a spray bottle is filled with the material, and the spray is obtained. According to the nut oil micro-emulsion spray, the excellent characteristics of macadimia nut green husks and the macadimia nut oil are combined and exerted, the spray has a remarkable effect especially on the aspect of inflammation diminishing, and the nut oil micro-emulsion spray has broad application prospects on the aspect of inflammation diminishing and itching relieving. The preparation method of the nut oil micro-emulsion spray is simple and convenient to operate, and industrialized production is easy to achieve.

The invention provides a preparation method of a nanoparticle composition delivery system, and belongs to the field of nano biomaterials. The preparation method comprises the following steps: preparing a cationic liposome raw material and an antitumor drug into an antitumor drug-loaded cationic liposome by adopting a film dispersion method; and mixing the antitumor drug-loaded cationic liposome with GAPDH-siRNA by adopting a mixed incubation method to prepare the nanoparticle composition delivery system, wherein the cationic liposome raw material comprises 2-dioleoyl hydroxypropyl-3-N, N, N-trimethylamine chloride, phytosterol, diacetone-D-galactose and dioleoyl phosphatidyl ethanolamine. The delivery system prepared by the preparation method of the nanoparticle composition delivery system provided by the invention has the advantages of high encapsulation efficiency, good stability, large drug and gene loading capacity, small particle size change, high cell uptake efficiency and uptake rate and the like.

The invention relates to the technical field of thermal transfer printing, and provides a thermal transfer dispersion color paste and a preparation method thereof, and a thermal transfer printing ink and a preparation method thereof. The components of the thermal transfer dispersion color paste provided by the present invention include dispersants, thermal transfer disperse dyes, humectants, surfactants, bactericides and water, wherein the dispersants are composed of benzyl methacrylate, methacrylate , initiator and solvent are prepared. The dispersant used in the color paste of the present invention has a high thermal cracking temperature, does not gasify at the working temperature of thermal transfer printing, and has good dispersion performance, which can improve the stability of the color paste. The transfer ink is not easy to age, and it will not produce white smoke and odor during thermal transfer. The invention also provides a thermal transfer ink, which is colorless and odorless in the color development process, has good fluency, high printing quality, and good nozzle moisturizing performance.

The invention discloses a posaconazole liquid suspension and a preparation method thereof. The raw materials are posaconazole, a microcrystalline cellulose-carboxymethylcellulose sodium compound, a nonionic surfactant, a buffer solution, dimeticone, sodium benzoate, titanium dioxide, high fructose syrup and a pharmaceutically acceptable liquid carrier; and wherein the pharmaceutically acceptable liquid carrier is purified water and glycerin. The posaconazole liquid suspension has the advantages of high stability, good reappearance between batches, and difficult settlement, and the preparation method has the advantages of simple process and easy industrialization.