48results about How to "Little change in particle size" patented technology

The invention discloses ultrafine aluminum alloy powder and a production method thereof, and relates to low-oxygen-content and ultrafine aluminum alloy powder and a production method thereof. The method comprises the following steps: melting high-purity aluminum which serves as a raw material and has the purity being 99.85 percent or above and other high-purity alloy elementary substances which serve as raw materials at high temperature to obtain aluminum alloy liquid, and jetting the alloy liquid into an atomization and settlement chamber protected by high-purity nitrogen (the purity is higher than 99.99 percent) through a spraying head under the conditions of high temperature of 450 to 700 DEG C, high-purity nitrogen (the purity is higher than 99.99 percent), the jetting pressure of 6 to 15 MPa and the gas / metal mass flow rate ratio of 6 to 15: 1, wherein the aluminum alloy liquid is quickly cooled by high-speed circulating flowing of the high-purity nitrogen in a system, and then spherical aluminum alloy powder with the particle size of 1 to 20 microns is collected. The oxygen content of the aluminum alloy powder is less than 0.2 percent, so that when the aluminum alloy powder is used as a material for metal powder injection molding, a product with a uniform microstructure, high density and good performance can be obtained.

The invention belongs to the field of biological medicine, and particularly relates to a nucleic acid lipid nano particle composition, a pharmaceutical preparation containing the same, and a preparation method and application thereof. The nucleic acid lipid nano particle composition comprises drug-loaded lipid nano particles and auxiliary materials, the mass ratio of the drug-loaded lipid nano particles to the auxiliary materials is (0.1-10): (90-99.9), the drug-loaded lipid nano particles comprise nucleic acid drugs and lipid carriers, the mass ratio of the nucleic acid drugs to the lipid carriers is 1: (2-30), the composition is good in stability, the nucleic acid drugs are not degraded due to too high temperature, the composition can be stored and transported at normal temperature, can be administered in various ways, and are quick in effect taking and high in bio-availability, large-scale production can be realized, the yield is high, and the repeatability is good.

The invention provides an oil-in-water drilling fluid with vegetable oil as an internal phase and a preparation method of the oil-in-water drilling fluid. The drilling fluid is prepared from the vegetable oil, water and a treating agent, wherein the volume ratio of the vegetable oil and water is 40:60 to 60:40; the treating agent comprises a main emulsifier, an auxiliary emulsifier, a filtrate loss reducer I, a thickening agent, NaOH, a thickening and shear strength improving agent, and a filtrate loss reducer II; based on 100 ml of vegetable oil and water, the content of the main emulsifier is 2-3.5 g, the content of the auxiliary emulsifier is 1-2.5 g, the content of the filtrate loss reducer I is 1-3.5 g, the content of the thickening agent is 1-1.5 g, the content of NaOH is 0.25-0.3 g, the content of the thickening and shear strength improving agent is 0.1-0.2 g, and the content of the filtrate loss reducer II is 1.5-4 g. The oil-in-water drilling fluid with the vegetable oil as the internal phase, provided by the invention, is stable in performance, high in drilling cutting resistance and clay pollution capacity, safe and environment-friendly, and can be directly discharged.

The invention relates to the technical field of a freeze-dried alprostadil composition for injection and a preparation method thereof. The freeze-dried alprostadil composition for injection comprises, by weight, 0.001 to 0.05 part of alprostadil, 1 to 50 parts of an emulsifier which is polyethylene glycol hydroxystearate or a mixture of polyethylene glycol hydroxystearate and phosphatide, 1 to 50 parts of medium chain triglyceride and 10 to 200 parts of other pharmaceutical adjuvant. According to stability test, the freeze-dried alprostadil composition can be stored in a shade place for 2 years, and the content of PGA1 is lower than 10%; the particle size of the composition changes a little before and after freeze-drying; after redissolving, the freeze-dried alprostadil composition appears to be transparent or has little opalescence, visible foreign matters can be inspected, and the redissolved composition has an average particle size of 10 to 100 nm, contains no emulsion droplet with a size of greater than 1 mu m and does not cause embolism of capillary vessels; the freeze-dried alprostadil composition does not contain short-chain alcohol co-emulsifiers, and the concentration of free alprostadil is low; and the freeze-dried alprostadil composition does not contain cyclodextrin adjuvant and has high security.

The invention belongs to the technical field of functional food processing, and discloses preparation of a protein-polysaccharide nano gel on the basis of Maillard reaction in a macromolecular crowding environment. The preparation method comprises the following steps: dissolving protein and polysaccharide in deionized water, stirring uniformly, regulating the pH value to 6.8-7, standing in a 4-DEG C refrigerator over night to perform hydration sufficiently, stirring at 60-95 DEG C to react for 6-48 hours, drying the reaction product to obtain powder, dissolving the powder in water to obtain a solution, regulating the pH value to the protein isoelectric point, carrying out heating treatment at 80-95 DEG C for 5-60 minutes, and cooling to obtain the protein-polysaccharide nano gel. The gel has the core-shell structure, has the advantages of small size and excellent stability, can be used for carrying biological active substances, and is hopeful to become the material for preparing new functional food.

The invention discloses a preparation method and application of a nut oil micro-emulsion spray. When the nut oil micro-emulsion spray is prepared, firstly, Tween-60 and hydrogenated castor oil serve as a composite surfactant, polyethylene glycol and nut oil serve as a mixed oil phase, nut oil nano micro-emulsion is prepared, then a macadimia nut green husk extracting solution and the nut oil nanomicro-emulsion are mixed, high-speed shearing dispersion and filtration are carried out, 95% edible alcohol, menthol and / or borneol are added, finally, the material is degermed and filtered, a spray bottle is filled with the material, and the spray is obtained. According to the nut oil micro-emulsion spray, the excellent characteristics of macadimia nut green husks and the macadimia nut oil are combined and exerted, the spray has a remarkable effect especially on the aspect of inflammation diminishing, and the nut oil micro-emulsion spray has broad application prospects on the aspect of inflammation diminishing and itching relieving. The preparation method of the nut oil micro-emulsion spray is simple and convenient to operate, and industrialized production is easy to achieve.

The invention discloses a carbon fiber composite emulsion sizing agent with low surface tension and high particle diameter stability. , 15-25% non-ionic surfactant, 0.5-2.5% antioxidant, 0.5-2.5% leveling agent, the preparation process includes (1) resin mixing, (2) adding additives, (3) adding deionization water and other steps. The solid content of the sizing agent emulsion prepared by the present invention is 30-60%, the pH of the emulsion is 7.0-9.0, the average particle diameter of the emulsion is 100-300nm, the particle diameter change rate is <15%, the surface tension of the emulsion is <35mN / m, and the prepared sizing agent The emulsion has high stability, can be stored for a long time, has strong ability to soak and absorb carbon fiber, and has good online sizing effect.

The invention belongs to the processing process of chemical products, and particularly relates to a precise processing process of fluorite powder. The processing process comprises the following steps: weighing 1000 parts of fluorite powder with the content of calcium fluoride of 85-95wt% at a normal temperature within 0-40 DEG C, wherein the content of barite does not exceed 0.6%; placing in a reaction container; adding 300-3000 parts of acidic liquor containing 10-50% of hydrogen fluoride; uniformly mixing a fluorite powder slurry; guiding the discharge material to a standing pool for standing for 1-24 hours; filtering by a filter; recycling the filtered liquid; spraying the filtered solids by 300-3000 parts of clean water; transferring the cleaned solids to a neutralization pond; adding 300-3000 parts of alkaline liquor, wherein the liquor is alkali and the pH value is 10-14; filtering again; spraying by 300-3000 parts of clean water after filtration, wherein the PH value of cleaned water liquor is 7-9; and transferring the cleaned solids to a drying furnace, wherein the content of calcium fluoride in high purity fluorite powder through detection is not less than 97%. The precise processing process of the fluorite powder is simple in process flow, easy to operate, simple in production equipment and low in investment cost.

The invention discloses W / O / W (water in oil in water ) type unsaturated guluronic acid nanometer cream, and aims to solve the technical problem of protecting the oxidation resistance of unsaturated guluronic acid. The invention further discloses a preparation method of the W / O / W type unsaturated guluronic acid nanometer cream. The W / O / W (water in oil in water ) type unsaturated guluronic acid nanometer cream is prepared by using edible oil, polyglycerol polyricinoleate, polyvinyl alcohol, Span-80, Tween-80 and unsaturated guluronic acid as raw materials, and adopting a high energy emulsification method. The W / O / W type unsaturated guluronic acid nanometer cream prepared by the preparation method is high in entrapment efficiency and good in stability, has the effect of slow release, and caneffectively prolong the medicine effects.

The invention discloses a sulbenicillin sodium liposome injection, which is characterized by comprising the following components in part by weight preferably: 1 part of sulbenicillin sodium, 3 to 5 parts of soya bean lecithin, 0.8 to 2 parts of cholesterol, 0.2 to 1 part of dipalmitoyl phosphatidylethanolamine, 0.1 to 0.5 part of antioxygen and 5 to 10 parts of excipient. The liposome injection prepared by the invention has the advantages of obvious technical effect, high dissolvability and stability, high encapsulating rates, small side effect, high bioavailability and obvious curative effect.

The invention discloses a preparation method for berberine-loaded phospholipid composite nanoparticles. The preparation method is characterized by comprising the following steps: (1), preparing a soybean phospholipid solution; (2), preparing a berberine ethanol solution; (3), adding the berberine ethanol solution into the soybean phospholipid solution, and carrying out rotary evaporation so as to obtain a phospholipid single-layer film; (4), redissolving the phospholipid single-layer film with an aprotic reaction reagent, and adding ultrapure water for secondary rotary evaporation so as to obtain nanoparticle suspension liquid; (5), adding a spray-drying protective agent into the nanoparticle suspension liquid to obtain an original medical solution; (6), atomizing the original medical solution through a single-line micro jet atomizer under a certain pressure, and drying in a spray-drying tower so as to obtain the berberine-loaded phospholipid composite nanoparticles. The entrapment efficiency of the berberine-loaded phospholipid composite nanoparticles prepared through the preparation method provided by the invention is 85% or above, the berberine-loaded phospholipid composite nanoparticles are uniform in particle size, the particle size is changed slightly after the berberine-loaded phospholipid composite nanoparticles are redissolved in water, in-vitro release of berberine is not influenced, the bioavailability is high and long-term storage stability is high.

The invention discloses a posaconazole liquid suspension and a preparation method thereof. The raw materials are posaconazole, a microcrystalline cellulose-carboxymethylcellulose sodium compound, a nonionic surfactant, a buffer solution, dimeticone, sodium benzoate, titanium dioxide, high fructose syrup and a pharmaceutically acceptable liquid carrier; and wherein the pharmaceutically acceptable liquid carrier is purified water and glycerin. The posaconazole liquid suspension has the advantages of high stability, good reappearance between batches, and difficult settlement, and the preparation method has the advantages of simple process and easy industrialization.

The invention provides a production method for polyphenylene ether (PPE) powder. The method can stably produce PPE powder with uniform small particle size, small residual solvent amount, excellent solvent solubility and easy blend with a liquid additive. The production method for the PPE powder comprises a polymerization step of polymerizing a phenolic compound in a good solvent of PPE to obtain a polymer solution and a precipitation step for generating a slurry by adding the polymer solution and a poor solvent relative to PPE in a precipitation tank and precipitating PPE. In the polymer solution added in the precipitation tank, when a concentration of PPE in a good solvent is set as X (mass%) and a mass ratio (poor solvent / good solvent) of the poor solvent added in the precipitation tank to the good solvent in the polymer solution is set as Y, X and Y meet the following formulas (I) and (II): 30<X<=48...(I); 18.032*(X / 100)<2>-1.1873*(X / 100)-0.3463<=Y<=22.430*(X / 100)<2>-1.4769*(X / 100)-0.1868 (II).

The invention relates to a suspension agent composition containing pyraclostrobin and a preparation method of the suspension agent composition. The suspension agent composition is prepared from the following components by weight: 1% to 30% of crude drug containing pyraclostrobin, 1% to 30% of surfactant, 0.1% to 3% of leveling agent, 0.1% to 1.0% of PH (potential of hydrogen) regulator, 0.1% to 1.0% of preservative, 1% to 20% of oily substance, and a thinner, wherein the total percent is 100 percent. The suspension agent composition has the advantage that by adopting the preparation formula, the difficult problem of poor stability in thermal storage of a pyraclostrobin suspension agent in the processing industry of pesticide preparations can be well solved.

The invention discloses a stem cell skin care product, and relates to the technical field of biological beauty. The stem cell skin care product is prepared from the following raw materials: adipose-derived stem cell exosome freeze-dried powder and a solvent, wherein the adipose-derived stem cell exosome freeze-dried powder is prepared from the following raw materials through freeze drying: a chitosan-adipose-derived stem cell exosome compound and a freeze-drying agent; and the solvent is prepared from arbutin, hyaluronic acid, total saponins of ginseng, radix scutellariae extract, glycerol, butanediol and de-ionized water. The skin care product provided by the invention has the synergistic effect of repairing, nourishing and activating, and has the effects of delaying skin ageing from the source, improving skin problems including dark yellow, rough skin and the like, fading spots and brightening, fading fine wrinkles, refining pores, repairing hyperplastic scars, improving skin sensitivity and the like.

The invention belongs to the technical field of medicine preparations, and particularly relates to a taxol freeze-dried powder preparation process and a product. The taxol freeze-dried powder preparation process is simple in route, production cost is low, transportation and storage is simple and convenient, and adverse reaction caused by addition of excipients is avoided. In-vitro stability of taxol micelle freeze-dried powder is higher, redissolved taxol solution is stably kept 12 hours or than at room temperature, and drug treatment requirements are met. Blood stability is higher, grain diameter is small, an EPR effect is more easily played, taxol freeze-dried powder can be redissolved by the aid of common normal saline or glucose injection, and drug administration processes are greatlysimplified.

The invention belongs to the technical field of food nano-gel, and discloses Maillard reaction-based vegetable protein nano-gel, as well as a preparation method and application thereof. The preparation method comprises the following steps: (1) dissolving vegetable protein and glucan in water, uniformly stirring, regulating pH, and drying to obtain powder; (2) putting the powder obtained in the step (1) in an environment having a temperature of 50-60 DEG C and a relative humidity of 65-79 percent to react for 4-6 days to obtain a Maillard reaction product; and (3) dissolving the Maillard reaction product in water to obtain a solution, regulating the pH to an isoelectric point, heating, and cooling to obtain the vegetable protein nano-gel. The nano-gel has good mono-dispersion, has a PDI value of 0.099 and a grain size of 30-220nm, has a core-shell structure and excellent stability, and has an excellent prospect in novel functional food ingredients and bioactivator delivery application.

The invention provides a cefsulodin sodium liposome injection, which is characterized by consisting of the following components in part by weight: 1 part of cefsulodin sodium, 1.8 to 13 parts of yolk lecithin, 0.3 to 7 parts of sodium glycyl-cholate, 0.1 to 5 parts of Tween 80, 0.02 to 3 parts of antioxidant and 2 to 20 parts of excipient. The cefsulodin sodium liposome injection prepared by the invention has the advantages of better solubility, better stability, high entrapment efficiency, lower side effect, higher bioavailability and more obvious treatment effect.

The invention relates to the technical field of heat transfer printing, and provides heat transfer printing disperse color paste and a preparation method thereof, and heat transfer printing ink and a preparation method thereof. The heat transfer printing disperse color paste provided by the invention comprises the following components of a dispersing agent, a heat transfer printing disperse dye, a humectant, a surfactant, a bactericide and water, wherein the dispersing agent is prepared from benzyl methacrylate, methacrylate, an initiator and a solvent. The dispersing agent used in the color paste is high in thermal cracking temperature, cannot be gasified at the working temperature of heat transfer printing and is good in dispersing performance, the stability of the color paste can be improved, and the heat transfer printing ink prepared from the color paste is not prone to aging and cannot generate white smoke and smell during heat transfer printing. The invention also provides the heat transfer printing ink. The heat transfer printing ink provided by the invention is colorless and odorless in color development process, good in smoothness, high in printing quality and good in nozzle moisturizing performance.

The invention discloses a lignite drying method and a lignite drying system. The lignite drying method comprises the following steps that (1) lignite is placed into a raw material tower; (2) gas in the raw material tower is exhausted to a drying tower so that the pressure in the raw material tower can be reduced, wherein the drying tower carries out drying processing on the gas; (3) the gas processed through drying in the step (2) is fed into the raw material tower again; (4) the step (2) and the step (3) are repeated until dry lignite is obtained. According to the lignite drying method, due to the fact that the gas in the raw material tower is exhausted to the drying tower, the pressure in the raw material tower can be reduced, moisture in the lignite can rapidly evaporate at a low temperature, energy consumption can be reduced, the drying rate can be increased, and meanwhile, the accidents such as spontaneous combustion and explosion, caused by local high temperature, of the lignite are avoided; in addition, due to the fact that the whole lignite drying system runs at the low pressure, the amount of dust generated by air flow when the air flow passes through the raw material tower is reduced.

The invention discloses a polydopamine-loaded hemoglobin micro-nano particle and a preparation method and application thereof. The polydopamine-loaded hemoglobin micro-nano particle is obtained by wrapping hemoglobin with polydopamine, the micro-nano particle takes manganese carbonate as an adsorption template, hemoglobin is immobilized to form a primary particle, then a polydopamine adhesion layer is constructed on the surface of the primary particle, and finally, removing manganese carbonate to obtain the polydopamine-loaded hemoglobin micro-nano particle. The polydopamine-loaded hemoglobin micro-nano particle has a wide blood substitute application prospect due to a simple synthesis process, a complete chemical structure and good oxygen carrying capacity, blood compatibility, biological safety and oxidation resistance, and can play an important role in the field of medicines.

The invention discloses a preparation method of water-soluble capsanthin and its products, which belong to the technical field of pigment processing. The method comprises the following steps: adding a cosolvent and an emulsifying carrier aqueous solution to the saponified capsanthin, After mixing and dispersing, the obtained dispersion liquid is homogenized to obtain the water-soluble capsanthin, and the co-solvent is glycerol, propylene glycol or ethanol; the method of the present invention can significantly improve the water solubility of capsanthin, and prepare The product can be miscible with water in any proportion, which greatly improves the application range of capsanthin; the water-soluble capsanthin prepared by the present invention has good stability, and after 30 days of dark storage, the product color value and particle size The change is small, maintained at a relevant stable level, and adopting the method of the present invention can significantly improve the effect of capsanthin on Cu 2+ , Fe 2+ , Fe 3+ Ions and stability to light and high temperature.

The invention discloses a dispersible pH sensitive cationic polymer gel sub-micron particle and making method, which comprises the following steps: allocating raw material through non-ion soluble macromolecular monomer, cation monomer, crosslinking agent and initiator weight rate at 20%-70%25%-75% 0.7%-3%0.7%-3%; dissolving in the acetonitrile or alcohol; aerating nitrogen to reflux; evaporating solvent; dripping secondary distill water; cooling dispersing liquid naturally; centrifuging to separate; dialyzing upper supernatant layer; freezing to drying; making the gel sub-micron particle disperse in the pure water, physiological saline and buffer as drug control carrier releasing material.

The invention provides a microemulsion droplet of a W / O / W type PCR amplified product based on a microfluidic system and a preparation method of the microemulsion droplet, the microemulsion droplet includes an amplified W / O type microemulsion droplet , an oil phase A and an outer water phase, wherein the amplified W / O microemulsion droplets include an inner water phase and an oil phase B, prepared by a microfluidic system, and the amplified W / O microemulsion droplets, oil phase A The volume ratio of the inner water phase to the outer water phase is 1:3:1000; the volume ratio of the inner water phase to the oil phase B is 40:3. The present invention provides a preparation method of W / O / W microemulsion droplets. The obtained microemulsion droplets can effectively establish a new type of microemulsion droplet sorting platform, and can effectively solve the problem of tissue The conundrum of cellular heterogeneity that samples cannot crack. In the present invention, by strictly screening the formula ratio and preparation parameters, the average particle diameter is 70 μm, all of which are spherical particles with uniform particle size distribution, and the stability experiment shows that the microemulsion droplets prepared by the present invention can be stored at room temperature, and The particle size changes little in a short time at room temperature.

The present invention discloses hyaluronic acid- g ‑Folic acid amphiphilic polymer and its application, the main chain is hydrophilic hyaluronic acid, and the side chain is hydrophobic folic acid, which can efficiently and stably load small molecule anticancer drugs and prolong the blood circulation time of drugs; The enrichment amount is high, reaching 12.0%ID / g. After reaching the tumor tissue, the dual-targeted nanomedicine tightly binds to the surface of tumor cells and effectively enters the tumor cells through receptor-mediated endocytosis, and then realizes The drug is released quickly, resulting in a highly effective therapeutic effect. The polymer of the present invention has good biocompatibility and degradability, and is convenient to be excreted from the body; it overcomes the shortcomings of low drug delivery efficiency, less accumulation in tumor sites, low cell endocytosis efficiency, and slow intracellular release; and the method is simple to prepare , the source of raw materials is abundant, and the obtained nanomedicine has excellent freeze-drying redispersibility, which is conducive to large-scale production and application.

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a preparation process and product of paclitaxel freeze-dried powder. The preparation process of the paclitaxel freeze-dried powder has the advantages of simple route, low production cost, and easier and more convenient transportation and storage, and avoids adverse reactions caused by adding excipients. The prepared paclitaxel micelle freeze-dried powder has high stability in vitro, and a paclitaxel solution obtained through redissolution of the paclitaxel micelle freeze-dried powder remains stable at room temperature for more than 12 hours and meets the requirements of drug treatment. The paclitaxel freeze-dried powder has higher blood stability, smaller particle size, and is more likely to exert an ERP effect. The paclitaxel freeze-dried powder can be re-dissolved by use of an ordinary physiological saline or glucose injection, and thus the administration process is greatly simplified.

The invention discloses a preparation method and application of a nut oil micro-emulsion spray. When the nut oil micro-emulsion spray is prepared, firstly, Tween-60 and hydrogenated castor oil serve as a composite surfactant, polyethylene glycol and nut oil serve as a mixed oil phase, nut oil nano micro-emulsion is prepared, then a macadimia nut green husk extracting solution and the nut oil nanomicro-emulsion are mixed, high-speed shearing dispersion and filtration are carried out, 95% edible alcohol, menthol and / or borneol are added, finally, the material is degermed and filtered, a spray bottle is filled with the material, and the spray is obtained. According to the nut oil micro-emulsion spray, the excellent characteristics of macadimia nut green husks and the macadimia nut oil are combined and exerted, the spray has a remarkable effect especially on the aspect of inflammation diminishing, and the nut oil micro-emulsion spray has broad application prospects on the aspect of inflammation diminishing and itching relieving. The preparation method of the nut oil micro-emulsion spray is simple and convenient to operate, and industrialized production is easy to achieve.

The invention provides a preparation method of a nanoparticle composition delivery system, and belongs to the field of nano biomaterials. The preparation method comprises the following steps: preparing a cationic liposome raw material and an antitumor drug into an antitumor drug-loaded cationic liposome by adopting a film dispersion method; and mixing the antitumor drug-loaded cationic liposome with GAPDH-siRNA by adopting a mixed incubation method to prepare the nanoparticle composition delivery system, wherein the cationic liposome raw material comprises 2-dioleoyl hydroxypropyl-3-N, N, N-trimethylamine chloride, phytosterol, diacetone-D-galactose and dioleoyl phosphatidyl ethanolamine. The delivery system prepared by the preparation method of the nanoparticle composition delivery system provided by the invention has the advantages of high encapsulation efficiency, good stability, large drug and gene loading capacity, small particle size change, high cell uptake efficiency and uptake rate and the like.

The invention relates to the technical field of thermal transfer printing, and provides a thermal transfer dispersion color paste and a preparation method thereof, and a thermal transfer printing ink and a preparation method thereof. The components of the thermal transfer dispersion color paste provided by the present invention include dispersants, thermal transfer disperse dyes, humectants, surfactants, bactericides and water, wherein the dispersants are composed of benzyl methacrylate, methacrylate , initiator and solvent are prepared. The dispersant used in the color paste of the present invention has a high thermal cracking temperature, does not gasify at the working temperature of thermal transfer printing, and has good dispersion performance, which can improve the stability of the color paste. The transfer ink is not easy to age, and it will not produce white smoke and odor during thermal transfer. The invention also provides a thermal transfer ink, which is colorless and odorless in the color development process, has good fluency, high printing quality, and good nozzle moisturizing performance.

The invention discloses a posaconazole liquid suspension and a preparation method thereof. The raw materials are posaconazole, a microcrystalline cellulose-carboxymethylcellulose sodium compound, a nonionic surfactant, a buffer solution, dimeticone, sodium benzoate, titanium dioxide, high fructose syrup and a pharmaceutically acceptable liquid carrier; and wherein the pharmaceutically acceptable liquid carrier is purified water and glycerin. The posaconazole liquid suspension has the advantages of high stability, good reappearance between batches, and difficult settlement, and the preparation method has the advantages of simple process and easy industrialization.