Redispersable pH-sensitive cation polymer hydrogel sub-micrometer grain and its preparation method

A technology of hydrogel submicron particles and cationic polymers, applied in the field of pH-sensitive hydrogel polymer materials, to achieve the effect of small particle size change and simple preparation process

Inactive Publication Date: 2009-02-25
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the preparation of redispersible hydrogel submicron particles using methacrylate or acrylate containing amine or ammonium ions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1.8848g methacrylic acid-N, N-dimethylaminoethyl ester, 0.062g tetraethylene glycol-bismethacrylate, 0.973g relative molecular mass are 2080 polyethylene glycol monomethyl ether acrylate and 0.04g Azobisisobutyronitrile and 70mL of acetonitrile were added to a 100mL four-necked bottle, nitrogen gas was passed for 20min, and the reaction was carried out under reflux at 80°C for 6h; 10mL of twice distilled water was added dropwise while distilling acetonitrile under normal pressure, and the dispersion was cooled naturally after the distillation was completed, and then After the cooled dispersion was centrifuged at 3000rpm for 15min, the supernatant was put into a dialysis bag with a cut-off molecular mass of 8000-14400 and dialyzed for 72h. The dialyzed dispersion was freeze-dried to obtain a white powder product.

[0015] The submicron particle size of the cationic polymer hydrogel prepared in this example is 295nm, and the particle size after fully swelling in pure water...

Embodiment 2

[0017] 2.2193g methacrylic acid-N, N-dimethylaminoethyl ester, 0.0888g tetraethylene glycol-bismethacrylate, 0.5918g relative molecular mass is 2080 polyethylene glycol monomethyl ether acrylate and 0.0592g Azobisisobutyronitrile and 70mL of acetonitrile were added to a 100mL four-necked bottle, nitrogen gas was passed for 20min, and the reaction was carried out under reflux at 80°C for 6h; 10mL of twice distilled water was added dropwise while distilling acetonitrile under normal pressure, and the dispersion was cooled naturally after the distillation was completed, and then After the cooled dispersion was centrifuged at 3000rpm for 15min, the supernatant was put into a dialysis bag with a cut-off molecular mass of 8000-14400 and dialyzed for 72h, and the dialyzed dispersion was freeze-dried to obtain a white powder product.

Embodiment 3

[0019] 0.7398g methacrylic acid-N, N-dimethylaminoethyl ester, 0.0592g tetraethylene glycol-bismethacrylate, 2.0713g relative molecular mass is 2080 polyethylene glycol monomethyl ether acrylate and 0.0888g Azobisisobutyronitrile and 70mL of acetonitrile were added to a 100mL four-necked bottle, nitrogen gas was passed for 20min, and the reaction was carried out under reflux at 80°C for 6h; 10mL of twice distilled water was added dropwise while distilling acetonitrile under normal pressure, and the dispersion was cooled naturally after the distillation was completed, and then After the cooled dispersion was centrifuged at 3000rpm for 15min, the supernatant was put into a dialysis bag with a cut-off molecular mass of 8000-14400 and dialyzed for 72h, and the dialyzed dispersion was freeze-dried to obtain a white powder product.

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PUM

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Abstract

The invention discloses a dispersible pH sensitive cationic polymer gel sub-micron particle and making method, which comprises the following steps: allocating raw material through non-ion soluble macromolecular monomer, cation monomer, crosslinking agent and initiator weight rate at 20%-70%25%-75% 0.7%-3%0.7%-3%; dissolving in the acetonitrile or alcohol; aerating nitrogen to reflux; evaporating solvent; dripping secondary distill water; cooling dispersing liquid naturally; centrifuging to separate; dialyzing upper supernatant layer; freezing to drying; making the gel sub-micron particle disperse in the pure water, physiological saline and buffer as drug control carrier releasing material.

Description

technical field [0001] The invention relates to a redispersible pH-sensitive cationic polymer hydrogel submicron particle and a preparation method thereof, belonging to the pH-sensitive hydrogel polymer material technology. Background technique [0002] Polymer hydrogel submicron particles are a kind of polymer particles with submicron structure, which can swell but not dissolve in water. Hydrogel submicron particles have the characteristics of hydrogel's environmental responsiveness, and have great potential in many fields such as environmental response, biomedicine, biosimulation, biosensory, fine materials, artificial muscles, chemical separation, etc., especially in the field of biomedicine. Huge application potential and broad application prospects. [0003] According to the different groups carried, hydrogel submicron particles can be divided into non-ionic and ionic hydrogel submicron particles, and ionic hydrogel submicron particles are further divided into cationic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/18C08F2/38C08F4/04
Inventor 董岸杰邓联东何晓华
Owner TIANJIN UNIV
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