Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Process of extracting total flavone glycoside from mistletoe and medicine composition thereof

A technology of total flavonoid glycosides and mistletoe, applied in the direction of drug combination, sugar derivatives, sugar derivatives, etc.

Inactive Publication Date: 2006-11-08
徐东铭
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese medicine mistletoe is used as a raw material to prepare a large amount of total flavonoid glycosides of mistletoe (the content reaches more than 50% w / w), and it is used for the prevention and treatment of cardiovascular and cerebrovascular sclerosis or embolism, arrhythmia and hypertension. to report

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Preparation of total flavonoid glycosides from mistletoe

[0061] Take 1kg of dried mistletoe and add 8kg of water, heat and boil three times, 40 minutes each time. Collect and combine the water extracts of gained, the extract is decolorized with 2% medicinal active carbon, or through ion resin decolorization, filters, and the filtrate is added to the macroporous adsorption resin (example AB-8, Tianjin, China) of treating with acid and alkali in advance Nankai University Chemistry) column, wash the column with deionized water until the eluate has no color, and then elute with 70% ethanol (about 500ml). The eluate was collected, recovered under reduced pressure, dried, and the resulting concentrate was dissolved in 80% ethanol solution, placed, and filtered. The filtrate was concentrated and dried under reduced pressure to obtain total flavonoid glycosides of mistletoe in yellow powder form.

Embodiment 2

[0063] Take 1kg of mistletoe and add 6kg of water, heat and boil three times, 40 minutes each time. Collect and combine the obtained water extracts, concentrate, add ethanol solution until the alcohol concentration is 70%, or extract with 85% ethanol solution, the extract or alcohol solution can be decolorized with 2% medicinal activated carbon, or through ion resin Decolorize, or directly filter without decolorization, recover the ethanol liquid until there is no alcohol liquid smell, add the liquid medicine to the macroporous adsorption resin (example AB-8, Nankai University Chemistry, Tianjin, China) column that has been treated with acid and alkali in advance, and use deionization The column was washed with water until the eluate was colorless, and then eluted with 70% ethanol (about 500ml). The eluate was collected and concentrated under reduced pressure under reflux to obtain total flavonoid glycosides of mistletoe as yellow powder.

Embodiment 3

[0065] Take 100 g of total flavonoid glycosides from mistletoe, dissolve them in 75% ethanol to make a 5% total flavonoid solution, decolorize them with activated carbon, filter, concentrate and dry under reduced pressure, add water for injection to make a 5% aqueous solution, and use a microporous membrane (φ0.20μm) filtered until clear, sterilized, aseptically dispensed into vials, 1ml per bottle, and freeze-dried in a freeze dryer to obtain final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a preparation process for extracting total flavonoid glycosides from mistletoe, using mistletoe as raw material, extracting with alcohol or water, filtering, purifying with a macroporous adsorption resin column, eluting with alcohol until colorless, and using 50 Collect the eluate after elution with %-95% alcohol, recover the alcohol until there is no alcohol smell, concentrate it into extract or dry powder under reduced pressure or normal pressure, dissolve it with 60%-95% alcohol, filter, and remove the precipitate and recover the filtrate, and recover the alcohol under reduced pressure to obtain the desired total flavonoids of mistletoe. The invention also discloses that the total flavonoid glycosides of mistletoe are used as the basic active ingredient to prepare anti-cardio-cerebrovascular sclerosis and embolism, anti-arrhythmia and blood pressure-lowering drugs, and to treat and prevent cardiovascular and cerebrovascular sclerosis and embolism, arrhythmia and high blood pressure. Medicinal use for pathological conditions such as blood pressure.

Description

Technical field: [0001] The invention discloses a method for extracting total flavonoid glycosides from mistletoe and a pharmaceutical composition thereof, specifically a pharmaceutical composition using total mistletoe flavonoid glycosides extracted from mistletoe as the basic active ingredient, and also relates to the mistletoe total flavonoid glycosides The preparation method of the flavonoid glycosides and the application of the new medical application of the total flavonoids of mistletoe belong to the technical field of the extraction method of the effective components of the traditional Chinese medicine and the new medical application thereof. Background technique: [0002] Mistletoe Viscum coloratum (komar.) Nakai. In plant taxonomy, it belongs to the genus Mistletoe of the family Morustaceae. Semi-parasitic evergreen small shrub, the main production area is in the northeast, and it mainly parasitizes on elm, birch, willow, maple, poplar and other trees. In tradition...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P9/10A61P9/12A61P9/06
Inventor 徐东铭刘平
Owner 徐东铭
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com