Chiral organic, inorganic polymer assembled catalyst, synthesis method and use

Abstract

A chiral organic-inorganic high-molecular assembly used as catalyst for preparing alpha-amino acid and its derivative, chiral amine and its derivative and 2-alkyl-1,4-butanedioic acid and its derivative from alpha-dehydroamino acid and its derivative, enamine and itaconic acid and their derivatives through asymmetric catalytic hydrogenation is prepared from P-contained chiral ligand and transition metal's ions through coordination.

Description

technical field [0001] The invention relates to a novel ligand, a chiral catalyst and a loading method and application of the chiral catalyst. Using phosphorus-containing chiral ligands and transition metal ions to form organic-inorganic polymer assemblies through coordination, the metal ions in the assemblies provide catalytic centers, and the ligands provide chiral environments. The advantage is that these assemblies are insoluble in common Organic solvents, thus providing a new way for heterogeneous asymmetric catalysis, because this type of heterogeneous chiral catalyst does not use any other organic or inorganic support, so it is called self-supporting chiral catalyst. The catalyst can be used for asymmetric catalytic hydrogenation of α-dehydroamino acid and its derivatives, various enamines, itaconic acid and its derivatives and other compounds. The asymmetric catalytic hydrogenation of the above compounds can be used in the synthesis of compounds such as α-amino acids ...

AI Technical Summary

Problems solved by technology

[0013] In the first loading mode, the ligands or active units are randomly loaded on the disordered polymer support, resulting in a lower loading of catalytically active species, while the stereoselectivity and catalytic efficiency of the catalyst are comparable to those of unsupported The corresponding homogeneous systems will be reduced to varying degrees; [[de Vos, D.E.; Vankelecom, I.F.J.; Jacobs, P.A., Eds.In Chiral Catalyst Immobilization and Recycling; Wiley-VCH: Weinheim, 2000.] The second mode It makes up for the shortcomings of the first mode and improves the loading capacity, catalytic activity and selectivity of the catalyst. There have been some successful reports in recent years, but relatively speaking, the synthesis of polymer ligands in this mode is cumbersome.

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