Methods instruments and materials for chondrocyte cell transplantation

Abstract

The present invention provides a method for the effective treatment of articulating joint surface cartilage in an animal by the transplantation of an implantable article including chondrocyte cells retained to an absorbable support matrix. The present invention is also directed to an instrument for placing and manipulating the implantable article at the site of implantation, and a retention device for securing the implantable article to the site of implantation. The present invention is also directed to an implantable article for cartilage repair in an animal, the implantable article including chondrocyte cells retained on an absorbable support matrix, and a method of making same. This invention also encompasses, in general, an article comprising an absorbable flexible support matrix for living cells grown and adhered thereto.

Description

field of invention

[0001] The present invention relates to chondrocyte transplantation, bone and cartilage transplantation, healing, joint repair and prevention of arthritic conditions. In particular, the present invention relates to new methods and tools for chondrocyte transplantation and cartilage regeneration. Background of the invention

[0002] More than half a million arthroplasties and total joint replacements are performed in the United States each year. About the same number of procedures are performed in Europe. The European caseload includes around 90,000 total knee replacements and 50,000 surgeries to repair knee defects. These case numbers are essentially the same in the United States (Praemer A., ​​Fumer S., Rice, D.P., State of the American Musculoskeletal, American Academy of Orthopedic Surgeons, Park Ridge, Ill., 1992, 125).

[0003] Approaches for cartilage regeneration therapy would be most effective and be performed at an early stage of joint damage, ...

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