Calcium phosphate cement and use and method for making same

A technology of calcium phosphate salt and cement, which is applied in application, dental preparations, compression molding cups, etc. It can solve the problems of operation time, solidification time not meeting the requirements, inability to solidify, and difficulty in adjustment, etc.

Inactive Publication Date: 2002-01-30
卡茨特科公司
View PDF0 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The CPCs of these patents usually have one or more of the following disadvantages: (1) additives with poor biological activity must be used; (2) the manufacturing process is more complicated; (3) the operating time (workin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Calcium phosphate cement and use and method for making same
  • Calcium phosphate cement and use and method for making same
  • Calcium phosphate cement and use and method for making same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1: heat treatment method

[0037] Ca(H 2 PO 4 ) 2 ·H 2 5 gm of O powder and 1.6 ml of 25 mM dilute phosphoric acid aqueous solution were thoroughly mixed and stirred for one minute, then placed in an oven at a constant temperature of 50°C for 15 minutes, the obtained dry mixture was taken out, and then ground for 20 minutes with a mechanical grinder to pulverize into fine particles. After weighing 1 gm of fine particles and mixing with 0.4 ml (1.0 M, pH=6.0) of phosphate aqueous solution to form a paste, the working time and setting time of the obtained paste were measured every 30 seconds. The work time is the time after the paste is complete that it becomes too viscous to be stirred. The setting time is the time a needle with a diameter of 1 mm can only penetrate the paste to a depth of 1 mm with an applied force of 1 / 4 pound. The operating time of the paste of this embodiment is 30 minutes, and the setting time is 1 hour.

[0038] The paste of this e...

Embodiment 2

[0039] Embodiment 2: vacuum treatment method

[0040] CaHPO 4 (DCPA) powder 5gm and 1.2ml of 25mM dilute phosphoric acid aqueous solution are fully mixed and stirred for one minute, placed in a vacuum environment of -100Pa and pumped for 30 minutes, wait until it is completely dry, take it out and grind it with a mechanical grinder for 20 minutes, and crush it into fine particles. After weighing 1 gm of fine particles and mixing with 0.4 ml (1.0 M, pH=6.0) phosphate aqueous solution to form a paste, the operation time and setting time of the paste were measured every 30 seconds. The operating time of the paste of this embodiment was 20.5 minutes, and the setting time was 24.0 minutes.

[0041] The paste of this example was placed in a large volume of deionized water immediately after formation and it was observed that the paste did not disperse. Embodiment 3: organic solvent treatment method

Embodiment 3

[0041] The paste of this example was placed in a large volume of deionized water immediately after formation and it was observed that the paste did not disperse. Embodiment 3: organic solvent treatment method

[0042] Mix 5gm of DCPA powder with 1.6ml of 25mM dilute phosphoric acid aqueous solution and stir for one minute, then add 1.6ml of acetone to make the paste fully mixed, then place it in a vacuum environment of -100Pa for 1 hour until it is completely dry Take it out and grind it with a mechanical grinder for 20 minutes, and crush it into fine particles. After weighing 1 gm of fine particles and mixing with 0.4 ml (1.0 M, pH=6.0) phosphate aqueous solution to form a paste, the operation time and setting time of the paste were measured every 30 seconds. The operating time of the paste of the present embodiment is 20.0 minutes, and the setting time is 22.0 minutes.

[0043] The paste of this example was placed in a large volume of deionized water immediately after form...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Login to view more

Abstract

A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm..

Description

technical field [0001] The present invention relates to a calcium phosphate cement, in particular to a fast-setting calcium phosphate cement used in dentistry and bone repair. Background technique [0002] Calcium phosphate cements (CPC for short) have been widely used as biocompatible implants or filling materials for dental and bone repairs. For related patents, see, for example, U.S. Nos. 4,959,104, 5,092,888, 5,180,426, 5,262,166, 5,336,264, 5,525,148, 5,053,212, 5,149,368, 5,342,441, 5,503,164, 5,542,973, 5,545,254, 5,695,729, and 5,814,681. The CPCs of these patents usually have one or more of the following disadvantages: (1) additives with poor biological activity must be used; (2) the manufacturing process is more complicated; (3) the operating time (working time) does not match the setting time (setting time) (4) cannot be directly solidified into the desired shape in water / blood / body fluid; and (5) does not have proper strength in a relatively short time after cur...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K6/838A61L24/00A61L24/02A61L27/12A61L27/50C04B12/02C04B14/36C04B28/34
CPCC04B28/34A61L24/02C04B14/366C04B28/346A61K6/033A61L27/50C04B2111/00836C04B28/344C04B12/02A61L27/12A61K6/0085A61K6/0643A61L24/001A61K6/75A61K6/864C04B20/1014C04B22/064C04B22/126C04B20/023C04B20/107
Inventor 陈瑾惠朱建平陈文正
Owner 卡茨特科公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap