Anticancer compoiste light ball with X-ray stimulated zinc oxide-porphyrin compound

A technology of porphyrin compound and zinc oxide, applied in the field of pharmaceuticals, can solve problems such as unrealizable and no proposed fluorescent agent

Inactive Publication Date: 2002-02-20
董国臣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since this idea does not propose a clear fluorescent agent, and relies on finding or manufacturing a fluor...

Method used

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  • Anticancer compoiste light ball with X-ray stimulated zinc oxide-porphyrin compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: zinc oxide hematoporphyrin derivative

[0053] Commercially available hematoporphyrin dihydrochloride at room temperature with 1:19 (V / V)H 2 SO 4 -HAc was mixed and stirred for a certain period of time, and the reaction mixture was slowly injected into 3% sodium acetate to make it pH 3-5, and the dark red precipitate was collected, filtered by suction, washed with water, dried under reduced pressure after draining, (synthetic route: Luzgina. V.N. et al, Khim-Farm, Zh., 1997, 11:26) obtained the hematoporphyrin derivative (HpD).

[0054] HpD and zinc powder (which can be nano-zinc), under the protection of carboxyl groups, make zinc and the substituent hydroxyl group (-OH) around the hematoporphyrin derivative undergo a specific reaction to generate zinc oxide hematoporphyrin derivatives.

[0055] X-ray excited zinc oxide hematoporphyrin and X-ray fluorescence analysis:

[0056] Using the conventional X-ray fluorescence analysis X-ray tube as the prima...

Embodiment 2

[0058] Embodiment 2: Zinc oxide phthalocyanine

[0059] Add 46 grams of phthalic anhydride, 120 grams of urea, 6.2 grams of zinc powder (nanometer zinc can be used), 18 grams of titanium tetrachloride and 3 grams of boric acid into 200 grams of nitrobenzene, heat to 190-200 ° C, react for 3 hours, after cooling Filter, remove the nitrobenzene in the filter cake by steam distillation, then treat with dilute sulfuric acid solution, and obtain zinc phthalocyanine after drying. It is also possible to purchase commercially available zinc phthalocyanine, and use zinc ligand oxygen to form zinc-oxygen and nitrogen complexes with zinc in the macrocycle of phthalocyanine porphyrin. Zinc oxide phthalocyanine can be purified by sulfuric acid dissolution-precipitation method to make nano zinc oxide phthalocyanine powder, which can be made into nano-patch of intravenous injection and transdermal drug delivery system (TDDS) (patent application number CN00136775.7).

[0060] X-ray excited z...

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Abstract

The present invention relates to the synthesis of zinc oxide and porphyrin derivative for use in X-ray excitation, photo-dynamic action of zine oxide and porphyrin compound is used to treat tumour and other diseases. It is made into intravenous injection liquid or nano medicine plaster.

Description

(1) Technical field: [0001] The anti-cancer photoelastic composition of X-ray excited zinc oxide porphyrin compound photodynamic action belongs to the technical field of medicines. [0002] The present invention relates to compounds used as porphyrin photosensitizers; [0003] The present invention also relates to a new compound photosensitizer which contains zinc oxide in the chemical structure of porphyrin derivatives and has special functions; [0004] The present invention also relates to an anti-cancer light that uses X-rays as excitation light to make zinc oxide in the structure of porphyrin derivatives emit secondary excitation light for porphyrin derivatives to absorb light and trigger photodynamic action to target and kill tumor tissues and other pathological tissues. bombs, especially the use of anti-cancer photoelastics to treat tumors and other diseases to achieve photokinetics and therapy; (two) background technology: [0005] As we all know, the combined phot...

Claims

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Application Information

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IPC IPC(8): A61K31/409A61K31/555A61K41/00
CPCA61K31/409A61K31/555A61K41/0071
Inventor 董国臣董文帅董京
Owner 董国臣
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