N,N'-diacetylcystine-arginine salt and its preparing process and usage

A technology of diacetylcystine arginine salt and diacetylcystine, which is applied to the preparation of sulfides, medical preparations containing active ingredients, and the digestive system, can solve problems such as complex production processes and improve survival rate, inhibition of type IV delayed hypersensitivity, and obvious curative effect

Inactive Publication Date: 2003-01-15
吴锡铭 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this organic salt still has the problem of moisture absorption, and the production process for purification is still relatively complicated.

Method used

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  • N,N'-diacetylcystine-arginine salt and its preparing process and usage

Examples

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example 1

[0026] Add 100g (0.42mol) of N-acetylcysteine ​​to 1000ml of deionized water, stir to dissolve, add sodium carbonate to make the solution pH = 10, feed oxygen for 4 hours under stirring, leave it at room temperature overnight, pass the solution through a cation exchange resin, and water Elution, eluent (pH2.0), add L-arginine to pH6.0~7.0, concentrate under reduced pressure (50°C) to syrupy state, add 1.5L ethanol, flow together for 10 minutes, cool the ethanol solution, filter The crystals were taken, washed with absolute ethanol, and dried (silica gel, vacuum) for 24 hours to obtain 53.8 g of white crystalline powder, yield: 53.8%.

[0027] [α] 20 D -59.0° (1%, H 2 O) mp200°C (melting and decomposing at the same time) E 1％ 1cm 386(H 2 O)

[0028] Elemental analysis Calculated amount Measured value

[0029] C 39.28 39.76

[0030] H 6.59 6.63

[0031]N 20.82 20.74 Example 2 Take 82g (0.5mol) of N-acetylcysteine ​​and add 600ml of 0.001mol / l copper sulfate solution, s...

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Abstract

A novel compound N,N'-diacetylcystine-arginine salt is prepared from N,N'-diacetylcystine through purifying, dissolving arginine in the solution of purified N,N'-diacetylcystine, vacuum concentrating, crystallizing, washing with solvent and drying. It can be used for treating hepatism, fulminant liver failure, deficient immunopathy, chronic infection and autoimmune disease.

Description

technical field [0001] The present invention relates to a kind of new compound and its preparation method and use, especially new compound N, N'-diacetylcystine arginine salt and its preparation method and use. Background technique [0002] N-acetylcysteine ​​is a known compound, which is a mucolytic agent, used for respiratory diseases, and can also be used for detoxification of fulminant liver failure caused by drug poisoning. Clinical studies in recent years have proved that it also has good curative effect on liver failure caused by hepatitis B virus. The mechanism of N-acetylcysteine ​​in treating liver failure may be related to its physiological effect of nitric oxide in the body. N-acetylcysteine ​​is a thiol compound that can be easily oxidized to disulfide. Given the ease of formation and high stability of disulfides, they are suspected impurity constituents present in mercaptans and other fairly reactive sulfur-containing compounds. [0003] N,N'-diacetylcystein...

Claims

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Application Information

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IPC IPC(8): A61K31/165A61P1/16A61P31/00A61P37/02C07C319/20C07C323/59
Inventor 吴锡铭王佩
Owner 吴锡铭
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