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Method and material for preparing biomedical material for construction of artificial blood vessel

A technology of biomedical materials and artificial blood vessels, applied in the direction of coating, etc., can solve the problems of unusable blood circulation system, uncontrollable reaction, and no practical significance for production, and achieve the effect of reducing risk and excellent biocompatibility

Inactive Publication Date: 2003-03-12
TSINGHUA UNIV
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Problems solved by technology

It is chitosan with sodium borohydride (NaBH 4 ) strong base solution at 115°C, carry out carboxymethylation, and then carry out sulfation with N,N-dimethylformamide·sulfur trioxide compound solution, and then separate the product. The disadvantage is that the reaction is impossible Controllability, it can not control the ratio of reaction and the occurrence of side reactions, the yield is very low, only academic value, no production practical significance
According to the search, after depositing a layer of heparin on the chitosan film, cardiovascular cells can grow smoothly, but this is only suitable for static cell culture experiments, not for dynamic blood circulation systems

Method used

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Embodiment Construction

[0021] [1] Screen out the high-purity chitosan material with a viscosity average molecular weight of 300,000.

[0022] Specific parameters of the material: the degree of deacetylation is 81.5%; the insoluble component in dilute acetic acid solution is less than 1%; the viscosity is 200mPa (1% in 1% acetic acid solution, 20°C).

[0023] [2] Purification of material. The chitosan powder was dissolved in 0.1 mol / L hydrochloric acid solution, and refluxed for 24 hours under the protection of nitrogen. After cooling to room temperature, use 2mol / L NaOH solution to neutralize to pH 5.8, then dialyze in deionized water completely, and freeze-dry.

[0024] [3] Synthesis of 6-O-sulfochitosan (6-O-sulfochitosan). Dissolve the purified chitosan in 2% formic acid solution, then add an appropriate amount of 1mol / L CuSO4.5H2O solution dropwise at room temperature, stir for 16 hours, filter and wash with water, acetone and ether in turn. The resulting product is completely dispersed in dr...

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Abstract

A biomedical material for configuring artificial blood vessel is prepared from the chitosan as substrate whose viscosity-average molecualar weight is about 300000 through purifying, 6-O-sulfonating, and N-sulfonate-6-O sulfonation to obtain a chemically modified N-sulfonate-6-O chitosan sulfate. Its advantages are high and regulatable anticoagulating activity, high biocompatibility and biodegrability, and low cost.

Description

technical field [0001] A preparation method and material for biomedical materials for constructing artificial blood vessels belong to the technical field of biomedical manufacturing of artificial blood vessels. technical background [0002] The incidence of cardiovascular disease, which accounts for an increasing proportion of the entire human disease spectrum, has now become one of the leading causes of human death. Ischemic heart disease accounts for the vast majority of cardiovascular diseases. Coronary artery bypass grafting is currently an effective primary treatment for myocardial revascularization in ischemic heart disease. In coronary artery bypass grafting for ischemic heart disease, the vascular graft used to reconstruct the myocardial blood flow pathway is one of the determinants of the surgical effect. [0003] At present, all kinds of vascular grafts are still preferably the human body's own blood vessels. However, the length of the body's own non-essential b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30C08B37/10
Inventor 邓劲光张秀芳公衍道赵南明
Owner TSINGHUA UNIV
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