Nano magnetic heating seed for thermotherapy, its preparation method and use

A nano-magnetic and nano-magnetic powder technology, which is applied in the field of magnetothermal seeds for hyperthermia treatment of tumors and its preparation, can solve the problems of large particle size of magnetic materials, discomfort for muscles, and inability to be taken orally.

Inactive Publication Date: 2003-04-16
南京伍盛纳米科技有限公司
View PDF0 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the magnetic thermal seeds used in the thermal therapy of magnetic thermal seeds are all magnetic materials above the micron level. Due to the large particle size of the magnetic materials, they are easy to agglomerate and are not suitable for injection into blood vessels, muscles, etc., nor can they be taken orally. They are only suitable for embedded There are two ways of using it: injection and injection into the tumor site, and there are limitations in the scope of application and therapeutic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Embodiment 1, preparation hyperthermia nano magnetothermal seed

[0010] Take by weighing the nanometer magnetic powder 100g that particle diameter is 5~10nm, through sterilizing with sprinkler alcohol, join in the 402g aqueous solution that contains 2g surfactant sodium hexametaphosphate, nanometer magnetic powder: surfactant: the weight ratio of water is 1 : 0.02:4, then use ultrasonic wave or stirring to fully disperse the nano magnetic powder evenly, remove the supernatant after centrifugation, then wash with water to remove excess surfactant, and use vacuum drying to make powdery solid nano magnetic powder for hyperthermia Magnetic seeds.

Embodiment 2

[0011] Embodiment 2. Preparation of nano-magnetic thermal seeds for hyperthermia without surfactant.

[0012] Take by weighing 100g of nano-magnetic powder with a particle size of 50-100nm, sterilize it at high temperature, and mix it into 2000g of pure water. Injectable nano-magnetic thermal seed water for hyperthermia.

Embodiment 3

[0013] Embodiment 3, preparation hyperthermia uses nanometer magnetothermal seed water

[0014] Take by weighing the magnetic powder 100g that particle diameter is 20~40nm, through high temperature sterilization, add surfactant hexadecyl dimethyl ammonium bromide 5g, join in 50g pure water, nanometer magnetic powder: surfactant: the weight of water The ratio is 1:0.05:0.5, fully dispersed into a colloidal form by grinding or ultrasonic waves, the supernatant is removed by sedimentation, washed with pure water to remove excess surfactant cetyldimethylammonium bromide, and then added to normal saline 2000g is fully dispersed to make nano-magnetic thermal seed water for hyperthermia.

[0015] The nano-magnetic powder used in the above embodiments can be nano-ferromagnetic magnetic powder, nano-ferromagnetic magnetic powder and nano-superparamagnetic magnetic powder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A magnetothermal nanometer seed for thermotherapy to tumor is prepared from nanometre magentic particles, surfactant and purified water in Wt ratio of 1:(0-0.05):(0.5-20) through fully mixing to obtain a colloid or suspension, washing with purified water to remove excessive surfactant, and adding aqueous solution, to obtain the injection, or drying to obtain the powder.

Description

technical field [0001] The invention relates to a nano-magnetic thermal seed for hyperthermia and its preparation method and application, which relates to a magnetic thermal seed for hyperthermia treatment of tumors made of nano-magnetic powder as a main component, its preparation method and application. Background technique [0002] Magnetic thermal seed hyperthermia is a hyperthermic method that utilizes the hysteresis thermogenic effect produced by magnetic thermal seeds in the tumor part of the body to heat tumors, selectively kill tumor cells, and treat tumors. Compared with other external hyperthermia methods, it has outstanding advantages such as accurate temperature control, precise positioning, no damage to normal tissues around the tumor, and safety and reliability. It has become an effective method for treating tumors. However, the magnetic thermal seeds used in the thermal therapy of magnetic thermal seeds are all magnetic materials above the micron level. Due to...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/04A61F7/00A61J3/00A61N2/10
Inventor 朱宏
Owner 南京伍盛纳米科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap