Flurbiprofenbab preparation and its preparation method

A technology of flurbiprofen and cataplasms, which is applied in the field of flurbiprofen cataplasms and its preparation, and can solve problems such as no reports of flurbiprofen cataplasms

Inactive Publication Date: 2003-09-24
上海宝龙药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are flurbiprofen gels, ointments, liniments, films, patches, etc

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Embodiment 1: preparation of flurbiprofen cataplasm, flurbiprofen content 1mg / cm 2

[0065] Formula and ratio:

[0066] Flurbiprofen 10g

[0067] Paraffin oil 12g

[0068] Diethyl sebacate 18g

[0069] Sodium Lauryl Sulfate 20g

[0070] Gelatin 50g

[0071] Glycerin 230g

[0072] Sodium polyacrylate 40g

[0073] Sodium Carboxymethyl Cellulose 30g

[0074] Kaolin 50g

[0075] Azone 10g

[0076] Citric acid 10g

[0077] Flavor 5g

[0078] Add water to 1000g

[0079] Preparation:

[0080] 1. Preparation of flurbiprofen emulsion:

[0081] Add flurbiprofen into diethyl sebacate according to the above ratio, heat to dissolve at 60°C, add paraffin oil, cool at room temperature, and form an oil phase. Dissolve sodium lauryl sulfate in 60ml of water, then pour into the above oil phase, and mix to form milk.

[0082] 2. Preparation of hydrophilic cataplasm matrix

[0083] Dissolve gelatin, glycerin, sodium polyacrylate, citric acid, and sodium carboxymethylcellul...

Embodiment 2

[0085] Add the flurbiprofen emulsion into the hydrophilic cataplasm base, then add the essence and azone and stir evenly to obtain a paste. After degassing, apply it evenly on the non-woven fabric, cover with polyethylene film, dry at 40°C, and cut into 80cm 2 / sheet, sealed package. Embodiment 2: preparation of flurbiprofen cataplasm, flurbiprofen content 1.2mg / cm 2 Formula and ratio: flurbiprofen 30g Tween-80 30g paraffin oil 45g diethyl adipate 55gd-sorbitol 275g gelatin 25g aluminum potassium sulfate 1.8g ethyl paraben 1g sodium polyacrylate 3.5g carboxymethyl Sodium cellulose 31g kaolin 16g polyvinylpyrrolidone K-90 3g azone 10g essence 3g distilled water Add to 1000g preparation method: 1. prepare flurbiprofen emulsion:

[0086] Add flurbiprofen into diethyl adipate according to the above ratio, heat to dissolve at 60°C, add paraffin oil, cool at room temperature, and form an oil phase. Add Tween-80 into 200ml of water, pour into the above oil phase, and mix to form...

Embodiment 3

[0089] Embodiment 3: preparation of flurbiprofen cataplasm, flurbiprofen content 1mg / cm 2

[0090] Formula and ratio:

[0091] Flurbiprofen 30g

[0092] Glycerin 300g

[0093] Gelatin 25g

[0094] Aluminum hydroxide 2.0g

[0095] Ethylparaben 1g

[0096] Sodium polyacrylate 2.5g

[0097] Sodium Carboxymethyl Cellulose 19g

[0098] Kaolin 16g

[0099] Polyvinylpyrrolidone K-90 3g

[0100] N-Methylpyrrolidone 10g

[0101] Flavor 8g

[0102] Add distilled water to 1000g Preparation method: 1. Prepare a hydrophilic cataplasm base

[0103] Dissolve gelatin, glycerin, sodium polyacrylate, sodium carboxymethylcellulose, aluminum hydroxide, and polyvinylpyrrolidone K-90 in 580ml of water according to the above proportions. 2. Preparation of flurbiprofen cataplasm

[0104] Add the flurbiprofen and kaolin that have passed through the 200 mesh sieve into the hydrophilic cataplasm matrix according to the above proportioning ratio, stir evenly, then add ethylparaben, essence, N-...

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PUM

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Abstract

The present invention relates to the field of medicine technology, in particular, it relates to a flurbiprofenbab preparation and its preparation method. Said preparation includes back lining layer, medicine storage layer and protecting film, said medicine storage layer is formed from flurbiprofen powder preparation or flurbiprofen emulsion, hydrophilic bab preparation matrix, osmotic acceleratorand additive. Its medicine-carrying quantity is large, moisture-holidng property and air permeability are good.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to a flurbiprofen cataplasm and a preparation method thereof. Background technique: [0002] Flurbiprofen (flurbiprofen) is a new non-steroidal anti-inflammatory drug with anti-inflammatory and analgesic effects. Effective and widely used for musculoskeletal and joint disorders such as rheumatism, rheumatoid arthritis, degenerative arthritis, osteoarthritis, ankylosing spondylitis; soft tissue disorders such as sprains and strains; mild pain relief such as dysmenorrhea and postoperative pain. But it, like other non-steroidal anti-inflammatory drugs, can easily cause gastrointestinal side effects such as peptic ulcer and bleeding when taken orally. The transdermal drug delivery preparation can increase the local drug concentration of flurbiprofen at the pain site, enhance the anti-inflammatory effect, and avoid adverse reactions of gastrointestinal drug delivery. There are flurbip...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/192A61K47/00A61P29/00
Inventor 丁雪鹰高申王世岭缪春辉陈宙艳管斐马光大蒋雪涛朱全刚张仰眉
Owner 上海宝龙药业股份有限公司
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